Explanipedia

Impact of Race on the Outcomes of Retinoblastoma Treated With Primary Enucleation: A Global Study of 1426 Patients Open

Swathi Kaliki, Vijitha S. Vempuluru, Alia Ahmad, Jesse L. Berry, Rosdali Díaz Coronado , et al. · 2024

Background To evaluate the clinical presentation, pathological features and outcomes of retinoblastoma based on the race of origin in a global cohort of patients. Methods Retrospective collaborative study of 1426 patients who underwent pri…

HIGH-RISK HISTOPATHOLOGICAL FEATURES OF RETINOBLASTOMA FOLLOWING PRIMARY ENUCLEATION Open

Swathi Kaliki, Vijitha S. Vempuluru, Komal Bakal, Samten Dorji, Vishakha Tanna , et al. · 2024

Purpose: To evaluate high-risk histopathological features following primary enucleation of eyes with retinoblastoma and assess the patient outcomes across continents. Methods: A retrospective study of 1,426 primarily enucleated retinoblast…

sIL-2R- an Immuno-biomarker for Prediction of Metastases in Uveal Melanoma Open

Vivian Barak, I. Kalickman, Jacob Pe’er · 2022

Significantly higher sIL-2R levels were evident in all UM patients with Mets. Significant increases in sIL-2R levels on serial evaluations indicated and predicted UM Mets, enabling earlier treatment of Mets, to improve survival.

Vitreoretinal lymphoma: Central nervous system lymphoma risk with unilateral or bilateral ocular tumour. A multicentre collaboration Open

Lauren A. Dalvin, José S. Pulido, Carol L. Shields, Alessandro Marchese, Elisabetta Miserocchi , et al. · 2022

Survival of uveal melanoma patients with additional malignancies. Open

Pablo Galarza, Jacob Pe’er, Shahar Frenkel · 2021

Efficacy and safety of intravitreal methotrexate for vitreo‐retinal lymphoma – 20 years of experience Open

Zohar Habot‐Wilner, Shahar Frenkel, Jacob Pe’er · 2021

Summary Vitreo‐retinal lymphoma (VRL) is the most common intraocular lymphoma and is highly associated with central nervous system (CNS) lymphoma (CNSL), both posing a therapeutic challenge. We investigated patients’ characteristics, effic…

Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma Open

Denise Carbonell, Sarakshi Mahajan, Soon‐Phaik Chee, Bianka Sobolewska, Rupesh Agrawal , et al. · 2021

A consensus meeting allowed the establishment of recommendations important for the diagnosis of VRL.

Visual assessment of commercial drivers in the South West Region of Cameroon Open

Brice Nguedia Vofo, Doris Ako Ayuk, Jacob Pe’er, Alain Chichom‐Mefire, Nicholas Tendongfor , et al. · 2021

Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma Open

Denise Carbonell, Sarakshi Mahajan, Soon‐Phaik Chee, Bianka Sobolewska, Rupesh Agrawal , et al. · 2021

To provide recommendations for diagnosis of vitreoretinal lymphoma (VRL). Literature was reviewed for reports supporting the diagnosis of VRL. A questionnaire (Delphi 1 round) was distributed to 28 participants. In the second round (Delphi…

Visual Assessment of Commercial Drivers in the South West Region of Cameroon Open

Brice Nguedia Vofo, Doris Ako Ayuk, Jacob Pe’er, Alain Chichom‐Mefire, Nicholas Tendongfor , et al. · 2020

Background: Driving is a visually intensive task. In Cameroon where the burden of road traffic deaths is high, visual assessment is not universally performed before the issuance of driver’s licenses. This study assesses the visual status o…

A novel type of corneal epitheliopathy from a new class of antibody-drug conjugate anti-cancer treatments Open

Shahar Frenkel, Abraham Solomon, Jacob Pe’er · 2020

Topical interferon alpha 2a for ocular surface tumors Open

Jacob Pe’er, Shahar Frenkel · 2020

The importance of cytokines analysis in the diagnosis of vitreoretinal lymphoma Open

Shahar Frenkel, Jacob Pe’er, Ron Kaufman, Bella Maly, Zohar Habot‐Wilner · 2020

Purpose To evaluate the efficacy of the different diagnostic tests for vitreoretinal lymphoma (VRL). Methods A cohort of 150 patients with a presumed diagnosis of VRL. Vitrectomy samples were analysed for cytology, monoclonality [polymeras…

Treatment of vitreo-retinal lymphoma - 20 years of experience Open

Jacob Pe’er, Zohar Habot‐Wilner, Shahar Frenkel · 2019

Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference Open

Justine R. Smith, Jacob Pe’er, Rubens Belfort Neto, Fátima Cardoso, Richard D. Carvajal , et al. · 2019

The 2018 Ocular Oncogenesis and Oncology Conference was held through a partnership of the Association for Research in Vision and Ophthalmology (ARVO) and the Champalimaud Foundation. Twenty-one experts from international ocular oncology ce…

Frequency of atypical vascularization during IAC for retinoblastoma Open

Jacob Pe’er, Nadav Levinger, José E. Cohen, Shahar Frenkel · 2018

Serum exosome analysis as a predictive biomarker for metastatic uveal melanoma Open

Shahar Frenkel, Shahar Luski, Pratibha Gaur, Jacob Pe’er, Saray Tabak , et al. · 2018

A novel combinatorial treatment option for metastatic uveal melanoma Open

Dudi Shneor, Shay Tayeb, Jacob Pe’er, Hanna Voropaev, Maria Gimmelshein , et al. · 2018

Uveal melanoma (UM) is the most frequent intraocular tumor in adult patients. When metastases occur, systemic therapy with alkylating agents (fotemustine or dacarbazine (DTIC)) has shown only modest efficacy. The common chemotherapeutic dr…

Leucine-Rich α-2-Glycoprotein-1 (LRG-1) Expression in Retinoblastoma Open

Radgonde Amer, Liran Tiosano, Jacob Pe’er · 2018

LRG-1 was highly expressed in human retinoblastoma sections, thus providing new insights into the molecular mechanism of retinoblastoma pathogenesis, and suggests a possible new therapeutic target. LRG-1 is a novel oncogene-associated prot…

Long‐term uveal melanoma survivors: measuring their quality of life Open

Shahar Frenkel, Hadas Rosenne, Daniel Briscoe, Karen Hendler, Ronen Bereket , et al. · 2018

Purpose Patients with uveal melanoma ( UM ) undergo lifelong follow‐up as metastases can occur more than 20 years after diagnosis. Little is known about the quality of life (QoL) of UM survivors over such an extended period. To investigate…

Leaky Choroidal Nevi: A Clinical, Imaging and Therapeutic Analysis Open

Shahar Frenkel, Gustavo A. Gutiérrez-Vargas, Jacob Pe’er · 2017

The Use of Intravitreal Methotrexate for Treating Vitreoretinal Lymphoma Open

Jacob Pe’er, Ron Kaufman, Shahar Frenkel · 2017

An international survey of classification and treatment choices for group D retinoblastoma Open

Christina Scelfo, Jasmine H. Francis, Vikas Khetan, Thomas M. Jenkins, Brian P. Marr , et al. · 2017

Worldwide there is no consensus on which IIRC version is used, systemic chemoreduction was the most frequently used initial treatment during the study period followed by enucleation and primary treatment modality, especially enucleation, v…

Drug delivery for ocular surface malignancies Open

Jacob Pe’er · 2016

The clinical presentation of retinoblastoma patients with mosaics Open

Shahar Frenkel, Jacob Pe’er · 2016

Brachytherapy with Ru-106 plaques as a primary treatment for retinoblastoma in Israel Open

Jacob Pe’er, Shahar Frenkel · 2016

Intraocular T-cell Lymphoma: Clinical Presentation, Diagnosis, Treatment, and Outcome Open

Florence Chaput, Radgonde Amer, Edoardo Baglivo, Valérie Touitou, Alexandra Kozyreff , et al. · 2016

T-cell IOL has variable clinical manifestations and prognosis. Systemic involvement, SRD, and vitreoretinal involvement were frequently observed.

The Pediatric Choroidal and Ciliary Body Melanoma Study Open

Rana’a T. Al‐Jamal, Nathalie Cassoux, Laurence Desjardins, Bertil Damato, Lazaros Konstantinidis , et al. · 2016

Pathology of eyelid tumors Open

Jacob Pe’er · 2016

The eyelids are composed of four layers: skin and subcutaneous tissue including its adnexa, striated muscle, tarsus with the meibomian glands, and the palpebral conjunctiva. Benign and malignant tumors can arise from each of the eyelid lay…

Whole Exome Sequencing Reveals Mutations in Known Retinal Disease Genes in 33 out of 68 Israeli Families with Inherited Retinopathies Open

Avigail Beryozkin, Elia Shevah, Adva Kimchi, Liliana Mizrahi‐Meissonnier, Samer Khateb , et al. · 2015

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