Raquel G. Jacob
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View article: Synthesis of 2-Aryl-3-(organoselanyl)-4<i>H</i>-benzo[4,5]imidazo[2,1-<i>b</i>][1,3]thiazines Promoted by <i>N</i>-Fluorobenzenesulfonimide (NFSI)
Synthesis of 2-Aryl-3-(organoselanyl)-4<i>H</i>-benzo[4,5]imidazo[2,1-<i>b</i>][1,3]thiazines Promoted by <i>N</i>-Fluorobenzenesulfonimide (NFSI) Open
An approach has been developed for the direct synthesis of various selenium-functionalized benzo[4,5]imidazo[2,1-b][1,3]thiazine derivatives via the electrophilic cyclization reaction between 2-(methylthio)-1-(3-arylprop-2-yn-1-yl)-1H-benz…
View article: Greening the Synthesis of 2,3‐Dihydrobenzofuran Selenides: I<sub>2</sub>/TBHP‐Promoted Selenocyclization of 2‐Allylphenols
Greening the Synthesis of 2,3‐Dihydrobenzofuran Selenides: I<sub>2</sub>/TBHP‐Promoted Selenocyclization of 2‐Allylphenols Open
In this work we describe the synthesis of selenium‐containing dihydrobenzofurans through the selenocyclization reaction of 2‐allylphenols. The reaction procedure uses only an I 2 /TBHP oxidant system at room temperature, enabling an effici…
View article: Synthesis of 4-(Phenylchalcogenyl)tetrazolo[1,5-a]quinolines by Bicyclization of 2-Azidobenzaldehydes with Phenylchalcogenylacetonitrile
Synthesis of 4-(Phenylchalcogenyl)tetrazolo[1,5-a]quinolines by Bicyclization of 2-Azidobenzaldehydes with Phenylchalcogenylacetonitrile Open
A general methodology to access valuable 4-(phenylchalcogenyl)tetrazolo[1,5-a]quinolines was developed by the reaction of 2-azidobenzaldehyde with phenylchalcogenylacetonitriles (sulfur and selenium) in the presence of potassium carbonate …
View article: CCDC 2081566: Experimental Crystal Structure Determination
CCDC 2081566: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2081567: Experimental Crystal Structure Determination
CCDC 2081567: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Visible light-promoted synthesis of 2-aryl-(3-organoselanyl)thieno[2,3-<i>b</i>]pyridines
Visible light-promoted synthesis of 2-aryl-(3-organoselanyl)thieno[2,3-<i>b</i>]pyridines Open
We describe a simple and environment-friendly visible light-promoted protocol to access 2-aryl-(3-organoselanyl)thieno[2,3-b]pyridines, through the selenocyclization of 3-(arylethynyl)-2-(alkylthio)pyridines in the presence of diorganyl di…
View article: 3-Isobutyl-5,5,7-tris(3-methylbut-2-en-1-yl)-1-phenyl-1,7-dihydro-4H-indazole-4,6(5H)-dione
3-Isobutyl-5,5,7-tris(3-methylbut-2-en-1-yl)-1-phenyl-1,7-dihydro-4H-indazole-4,6(5H)-dione Open
Here we describe the functionalization of lupulone natural compound in obtaining 3-isobutyl-5,5,7-tris(3-methylbut-2-en-1-yl)-1-phenyl-1,7-dihydro-4H-indazole-4,6(5H)-dione. The lupulone-H-indazole derivative was prepared with 75% yield th…
View article: CCDC 2106971: Experimental Crystal Structure Determination
CCDC 2106971: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Elemental Chalcogen (Se, S) in PEG-400 to the Synthesis of Seleno- and Thioflavones from 2-Chlorophenyl Ethynyl Ketone and Nucleophilic Species of Chalcogen
Elemental Chalcogen (Se, S) in PEG-400 to the Synthesis of Seleno- and Thioflavones from 2-Chlorophenyl Ethynyl Ketone and Nucleophilic Species of Chalcogen Open
An alternative green method was developed for the synthesis of thio-and selenoflavones by the ring closure of 2-chlorophenyl ethynyl ketone with NaHY (Y = S, Se). These nucleophilic chalcogen species were generated in situ using NaBH4 to r…
View article: Recent Advances in the Oxone-Mediated Synthesis of Heterocyclic Compounds
Recent Advances in the Oxone-Mediated Synthesis of Heterocyclic Compounds Open
Oxone is a commercially available oxidant, composed of a mixture of three inorganic species, being the potassium peroxymonosulfate (KHSO5) the reactive one. Over the past few decades, this cheap and environmentally friendly oxidant has bec…
View article: Selective Synthesis of 2-(1,2,3-Triazoyl) Quinazolinones through Copper-Catalyzed Multicomponent Reaction
Selective Synthesis of 2-(1,2,3-Triazoyl) Quinazolinones through Copper-Catalyzed Multicomponent Reaction Open
We describe here our results from the copper-catalyzed three component reaction of 2-azidobenzaldehyde, anthranilamide and terminal alkynes, using Et3N as base, and DMSO as solvent. Depending on the temperature and amount of Et3N used in t…
View article: Five-Membered Cyclic Carbonates: Versatility for Applications in Organic Synthesis, Pharmaceutical, and Materials Sciences
Five-Membered Cyclic Carbonates: Versatility for Applications in Organic Synthesis, Pharmaceutical, and Materials Sciences Open
This review presents the recent advances involving several applications of five-membered cyclic carbonates and derivatives. With more than 150 references, it covers the period from 2012 to 2020, with special emphasis on the use of five-mem…
View article: Corrigendum: Ultrasound‐Assisted Multicomponent Reactions, Organometallic and Organochalcogen Chemistry
Corrigendum: Ultrasound‐Assisted Multicomponent Reactions, Organometallic and Organochalcogen Chemistry Open
In the originally published manuscript, there is an error regarding the acknowledgements from Luca Sancineto. The correct acknowledgement is given below: “LS acknowledges the European Union's Horizon 2020 research and innovation programme …
View article: Elemental Chalcogen (Se, S) in PEG-400 to the Synthesis of Seleno- and Thioflavones from 2-Chlorophenyl Ethynyl Ketone and Nucleophilic Species of Chalcogen
Elemental Chalcogen (Se, S) in PEG-400 to the Synthesis of Seleno- and Thioflavones from 2-Chlorophenyl Ethynyl Ketone and Nucleophilic Species of Chalcogen Open
An alternative green method was developed for the synthesis of thio- and selenoflavones by the ring closure of 2-chlorophenyl ethynyl ketone with NaHY (Y = S, Se). These nucleophilic chalcogen species were generated in situ using NaBH4 to …
View article: Solvent and Metal-Free Synthesis of 3-(<em>organochalcogenyl</em>)-2<em>H</em>-indazoles by Direct Chalcogenation of 2<em>H</em>-indazoles Using I<em><sub>2</sub></em>/DMSO as Catalytic System
Solvent and Metal-Free Synthesis of 3-(<em>organochalcogenyl</em>)-2<em>H</em>-indazoles by Direct Chalcogenation of 2<em>H</em>-indazoles Using I<em><sub>2</sub></em>/DMSO as Catalytic System Open
Indazoles are fused azaheterocycles with wide applicability in the medical field. In the last decades, the pharmacology interest in this nucleus has increased due to a variety of compounds that show biological activities. Among them are an…
View article: Selective Synthesis of Ketoxime Isomers Using Selenocompounds as a Catalyst
Selective Synthesis of Ketoxime Isomers Using Selenocompounds as a Catalyst Open
Oximes are important intermediates in organic synthesis and they have been used as building blocks in many organic transformations. They are used in the synthesis of N-substituted amides by Beckmann rearrangement or in the production of pl…
View article: Ultrasound and Oxone® promoting regioselective selenofunctionalization of chromone
Ultrasound and Oxone® promoting regioselective selenofunctionalization of chromone Open
Selective, simple and green synthetic procedures constitute an important goal in organic synthesis.In this sense, we describe the synthesis of 3-(organylselanyl)-4H-chromen-4-ones by regioselective selenofunctionalization of the chromone c…
View article: Oxone®-Promoted One-Pot Synthesis of 1-Aryl-4-(organylselanyl)-1H-pyrazoles
Oxone®-Promoted One-Pot Synthesis of 1-Aryl-4-(organylselanyl)-1H-pyrazoles Open
We describe herein an efficient protocol for the one-pot synthesis of 4-organylselanylpyrazoles by direct cyclocondensation and C-H bond selenylation reactions starting from hydrazines, 1,3-diketones and diorganyl diselenides promoted by O…
View article: Oxone®-Promoted One-Pot Synthesis of 1-Aryl-4-(organylselanyl)-1H-pyrazoles
Oxone®-Promoted One-Pot Synthesis of 1-Aryl-4-(organylselanyl)-1H-pyrazoles Open
We describe herein an efficient protocol for the one-pot synthesis of 4-organylselanylpyrazoles by direct cyclocondensation and C-H bond selenylation reactions starting from hydrazines, 1,3-diketones and diorganyl diselenides promoted by O…
View article: CCDC 1853770: Experimental Crystal Structure Determination
CCDC 1853770: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Molecular iodine-catalyzed one-pot multicomponent synthesis of 5-amino-4-(arylselanyl)-1<i>H</i>-pyrazoles
Molecular iodine-catalyzed one-pot multicomponent synthesis of 5-amino-4-(arylselanyl)-1<i>H</i>-pyrazoles Open
A one-pot iodine-catalyzed multicomponent reaction has been developed for the selective preparation of 5-amino-4-(arylselanyl)-1 H -pyrazoles from a diverse array of benzoylacetonitriles, arylhydrazines and diaryl diselenides. The reaction…
View article: Ultrasound-promoted synthesis of 2-organoselanyl-naphthalenes using Oxone <sup>®</sup> in aqueous medium as an oxidizing agent
Ultrasound-promoted synthesis of 2-organoselanyl-naphthalenes using Oxone <sup>®</sup> in aqueous medium as an oxidizing agent Open
A green methodology to synthesize 2-organoselanyl-naphthalenes based on the reaction of alkynols with diaryl diselenides is described. The electrophilic species of selenium were generated in situ, by the oxidative cleavage of the Se–Se bon…
View article: Eucalyptus Oil-Mediated Synthesis of Gold Nanoparticles
Eucalyptus Oil-Mediated Synthesis of Gold Nanoparticles Open
The search for efficient methods for the synthesis of metal nanoparticles has been widely explored.Within this context, the use of biological materials such as plants, algae, bacteria and fungi has been reported to various metal nanopartic…
View article: Synthesis, Antimicrobial, and Antioxidant Activities of Chalcogen-Containing Nitrone Derivatives from (R)-citronellal
Synthesis, Antimicrobial, and Antioxidant Activities of Chalcogen-Containing Nitrone Derivatives from (R)-citronellal Open
Background: The main constituents of Cymbopogonnardus (L) Rendle and C. citratus (DC) Stapfessential oils are (R)-citronellal and citral, respectively. Organochalcogen compounds can boost the biological activities of natural products. Meth…
View article: Ultrasound-promoted organocatalytic enamine–azide [3 + 2] cycloaddition reactions for the synthesis of ((arylselanyl)phenyl-1<i>H</i>-1,2,3-triazol-4-yl)ketones
Ultrasound-promoted organocatalytic enamine–azide [3 + 2] cycloaddition reactions for the synthesis of ((arylselanyl)phenyl-1<i>H</i>-1,2,3-triazol-4-yl)ketones Open
The use of sonochemistry is described in the organocatalytic enamine–azide [3 + 2] cycloaddition between 1,3-diketones and aryl azidophenyl selenides. These sonochemically promoted reactions were found to be amenable to a range of 1,3-dike…
View article: Green Hydroselenation of Aryl Alkynes: Divinyl Selenides as a Precursor of Resveratrol
Green Hydroselenation of Aryl Alkynes: Divinyl Selenides as a Precursor of Resveratrol Open
A simple and efficient protocol to prepare divinyl selenides has been developed by the regio- and stereoselective addition of sodium selenide species to aryl alkynes. The nucleophilic species was generates in situ, from the reaction of ele…