Jacob T. Edwards
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View article: Abstract 2090 The Effect of Cellular Differentiation on Adeno-Associated Viral Vector Genome Status
Abstract 2090 The Effect of Cellular Differentiation on Adeno-Associated Viral Vector Genome Status Open
View article: Discovery of an Azabicyclo[2.1.1]hexane Piperazinium Salt and Its Application in Medicinal Chemistry via a Rearrangement
Discovery of an Azabicyclo[2.1.1]hexane Piperazinium Salt and Its Application in Medicinal Chemistry via a Rearrangement Open
Herein we report the discovery of an azabicyclo[2.1.1]hexane piperazinium methanesulfonate salt from an unexpected rearrangement reaction in the preparation of ligand-directed degraders (LDDs). This bench-stable compound was found to be a …
View article: Chemoselective Electrosynthesis Using Rapid Alternating Polarity
Chemoselective Electrosynthesis Using Rapid Alternating Polarity Open
Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shie…
View article: Chemoselective, Scalable Nickel‐Electrocatalytic <i>O</i> ‐Arylation of Alcohols
Chemoselective, Scalable Nickel‐Electrocatalytic <i>O</i> ‐Arylation of Alcohols Open
The formation of aryl‐alkyl ether bonds through cross coupling of alcohols with aryl halides represents a useful strategic departure from classical S N 2 methods. Numerous tactics relying on Pd‐, Cu‐, and Ni‐based catalytic systems have em…
View article: Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols
Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols Open
The formation of aryl-alkyl ether bonds through cross coupling of alcohols with aryl halides represents a useful strategic departure from classical SN2 methods. Numerous tactics relying on Pd-, Cu-, and Ni-based catalytic systems have emer…
View article: Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols
Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols Open
The formation of aryl-alkyl ether bonds through cross coupling of alcohols with aryl halides represents a useful strategic departure from classical SN2 methods. Numerous tactics relying on Pd-, Cu-, and Ni-based catalytic systems have emer…
View article: Chemoselective Electrosynthesis Using Rapid Alternating Polarity
Chemoselective Electrosynthesis Using Rapid Alternating Polarity Open
Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome using either reagents/catalysts that tunably interact with a substrate or through modification to shield …
View article: Chemoselective Electrosynthesis Using Rapid Alternating Polarity
Chemoselective Electrosynthesis Using Rapid Alternating Polarity Open
Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome using either reagents/catalysts that tunably interact with a substrate or through modification to shield …
View article: CCDC 1935555: Experimental Crystal Structure Determination
CCDC 1935555: Experimental Crystal Structure Determination Open
View article: CCDC 1935556: Experimental Crystal Structure Determination
CCDC 1935556: Experimental Crystal Structure Determination Open
View article: CCDC 1935554: Experimental Crystal Structure Determination
CCDC 1935554: Experimental Crystal Structure Determination Open
View article: CCDC 1935557: Experimental Crystal Structure Determination
CCDC 1935557: Experimental Crystal Structure Determination Open
View article: CCDC 1935553: Experimental Crystal Structure Determination
CCDC 1935553: Experimental Crystal Structure Determination Open
View article: Impact of Stereo- and Regiochemistry on Energetic Materials
Impact of Stereo- and Regiochemistry on Energetic Materials Open
The synthesis, physical properties, and calculated performances of six stereo- and regioisomeric cyclobutane nitric ester materials are described. While the calculated performances of these isomers, as expected, were similar, their physica…
View article: Impact of Stereo- and Regiochemistry on Energetic Materials
Impact of Stereo- and Regiochemistry on Energetic Materials Open
The synthesis, physical properties and calculated performances of six stereo- and regioisomeric cyclobutane nitric ester materials is described. While the calculated performances of these isomers, as expected, were similar, their physical …
View article: Impact of Stereo- and Regiochemistry on Energetic Materials
Impact of Stereo- and Regiochemistry on Energetic Materials Open
The synthesis, physical properties and calculated performances of six stereo- and regioisomeric cyclobutane nitric ester materials is described. While the calculated performances of these isomers, as expected, were similar, their physical …
View article: A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines
A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines Open
Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and amines are of foundational importance to the practice of organic synthesis. After placing this work in proper historical context, this Article reports th…
View article: A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines
A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines Open
Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and amines are of foundational importance to the practice of organic synthesis. After placing this work in proper historical context, this Article reports th…
View article: Corrigendum: Nickel‐Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms
Corrigendum: Nickel‐Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms Open
In this Communication, compound 41 was assigned as the exo stereochemistry upon Giese reaction of ap yrroloindoline redox-active ester with benzyl acrylate.On subsequent NOESY studies of 41,acorrelation between H2 and H5 was observed.There…
View article: Berichtigung: Nickel‐Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms
Berichtigung: Nickel‐Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms Open
View article: CCDC 1819896: Experimental Crystal Structure Determination
CCDC 1819896: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1819895: Experimental Crystal Structure Determination
CCDC 1819895: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1590143: Experimental Crystal Structure Determination
CCDC 1590143: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1590142: Experimental Crystal Structure Determination
CCDC 1590142: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1590144: Experimental Crystal Structure Determination
CCDC 1590144: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Sulfones: A New Functional Group for Modular Radical Cross-Coupling
Sulfones: A New Functional Group for Modular Radical Cross-Coupling Open
Cross-coupling chemistry comprises the vast majority of reactions employed in the synthesis of medicines, agrochemicals, and other functional materials. The interest in single-electron-induced coupling chemistry stems from the unique abili…
View article: Sulfones: A New Functional Group for Modular Radical Cross-Coupling
Sulfones: A New Functional Group for Modular Radical Cross-Coupling Open
Cross-coupling chemistry comprises the vast majority of reactions employed in the synthesis of medicines, agrochemicals, and other functional materials. The interest in single-electron-induced coupling chemistry stems from the unique abili…
View article: Decarboxylative alkenylation
Decarboxylative alkenylation Open
View article: Fe-Catalyzed C–C Bond Construction from Olefins via Radicals
Fe-Catalyzed C–C Bond Construction from Olefins via Radicals Open
This Article details the development of the iron-catalyzed conversion of olefins to radicals and their subsequent use in the construction of C-C bonds. Optimization of a reductive diene cyclization led to the development of an intermolecul…
View article: CCDC 1522544: Experimental Crystal Structure Determination
CCDC 1522544: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …