Jacob T. Mey
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View article: Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes
Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes Open
Background Activation of mitochondrial fission and quality control occur early in the onset of insulin resistance in human skeletal muscle. We hypothesized that differences in mitochondrial dynamics, structure and bioenergetics in humans w…
View article: Plasma undercarboxylated osteocalcin dynamics with glycemic stress reflects insulin sensitivity and beta-cell function in humans with and without T2DM
Plasma undercarboxylated osteocalcin dynamics with glycemic stress reflects insulin sensitivity and beta-cell function in humans with and without T2DM Open
View article: Ketogenic propensity is differentially related to lipid‐induced hepatic and peripheral insulin resistance
Ketogenic propensity is differentially related to lipid‐induced hepatic and peripheral insulin resistance Open
Aim Determine the ketogenic response (β‐hydroxybutyrate, a surrogate of hepatic ketogenesis) to a controlled lipid overload in humans. Methods In total, nineteen young, healthy adults (age: 28.4 ± 1.7 years; BMI: 22.7 ± 0.3 kg/m 2 ) receiv…
View article: Effects of ketone bodies on energy expenditure, substrate utilization, and energy intake in humans
Effects of ketone bodies on energy expenditure, substrate utilization, and energy intake in humans Open
The potential of ketogenic approaches to regulate energy balance has recently gained attention since ketones may influence both energy expenditure and energy intake. In this narrative review, we summarized the most relevant evidence about …
View article: Soluble RAGE and skeletal muscle tissue RAGE expression profiles in lean and obese young adults across differential aerobic exercise intensities
Soluble RAGE and skeletal muscle tissue RAGE expression profiles in lean and obese young adults across differential aerobic exercise intensities Open
This study is the first to investigate the effects of aerobic exercise intensity on circulating sRAGE isoforms, muscle RAGE protein, and muscle RAGE splicing. sRAGE isoforms tended to diminish with exercise, although this effect was attenu…
View article: Guidelines for parenteral nutrition in preterm infants: The American Society for Parenteral and Enteral Nutrition
Guidelines for parenteral nutrition in preterm infants: The American Society for Parenteral and Enteral Nutrition Open
Background Parenteral nutrition (PN) is prescribed for preterm infants until nutrition needs are met via the enteral route, but unanswered questions remain regarding PN best practices in this population. Methods An interdisciplinary commit…
View article: Exercise-induced changes to the fiber type-specific redox state in human skeletal muscle are associated with aerobic capacity
Exercise-induced changes to the fiber type-specific redox state in human skeletal muscle are associated with aerobic capacity Open
This study is the first to use autofluorescent imaging to describe differential redox states within human skeletal muscle fiber types with exercise. Our findings highlight an easy and efficacious technique for assessing skeletal muscle red…
View article: Factors Influencing Nutritional Intake and Interests in Educational Content of Athletes and Sport Professionals Toward the Development of a Clinician-Supported Mobile App to Combat Relative Energy Deficiency in Sport: Formative Research and a Description of App Functions
Factors Influencing Nutritional Intake and Interests in Educational Content of Athletes and Sport Professionals Toward the Development of a Clinician-Supported Mobile App to Combat Relative Energy Deficiency in Sport: Formative Research and a Description of App Functions Open
Background Relative energy deficiency in sport (RED-S) as a consequence of athlete malnutrition remains a prominent issue. However, it remains underrecognized, in part due to the perceived outward health of athletes. The Eat2Win app was de…
View article: The Role of Nutrition in Mitigating the Effects of COVID-19 from Infection through PASC
The Role of Nutrition in Mitigating the Effects of COVID-19 from Infection through PASC Open
The expansive and rapid spread of the SARS-CoV-2 virus has resulted in a global pandemic of COVID-19 infection and disease. Though initially perceived to be acute in nature, many patients report persistent and recurrent symptoms beyond the…
View article: Novel index to predict mortality and inform malnutrition?
Novel index to predict mortality and inform malnutrition? Open
In the 1974 landmark publication The Skeleton in the Hospital Closet, the physician Charles E Butterworth described his observations of the pervasiveness and consequences of malnutrition in clinical populations.1Butterworth Jr, CE The skel…
View article: Factors Influencing Nutritional Intake and Interests in Educational Content of Athletes and Sport Professionals Toward the Development of a Clinician-Supported Mobile App to Combat Relative Energy Deficiency in Sport: Formative Research and a Description of App Functions (Preprint)
Factors Influencing Nutritional Intake and Interests in Educational Content of Athletes and Sport Professionals Toward the Development of a Clinician-Supported Mobile App to Combat Relative Energy Deficiency in Sport: Formative Research and a Description of App Functions (Preprint) Open
BACKGROUND Relative energy deficiency in sport (RED-S) as a consequence of athlete malnutrition remains a prominent issue. However, it remains underrecognized, in part due to the perceived outward health of athletes. The Eat2Win app was d…
View article: Emerging Nutrition Approaches to Support the Mind and Muscle for Healthy Aging
Emerging Nutrition Approaches to Support the Mind and Muscle for Healthy Aging Open
This narrative review highlights recent advances and ongoing trials using nutrition approaches for healthy aging. Focus will be placed on nutrition therapies that target cognition (“the mind”) and mobility (“the muscle”), both critical com…
View article: Reply to R Kirwan et al.
Reply to R Kirwan et al. Open
View article: Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism
Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism Open
Aerobic exercise is an effective tool in the prevention and treatment of several chronic metabolic diseases. However, the mechanisms through which these benefits are conferred have yet to be fully elucidated. Our data reveal a novel effect…
View article: The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions
The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions Open
View article: Insulin resistance persists despite a metabolically healthy obesity phenotype
Insulin resistance persists despite a metabolically healthy obesity phenotype Open
Objective Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross‐sectionally compared with…
View article: Behavioral Characteristics and Self-Reported Health Status among 2029 Adults Consuming a “Carnivore Diet”
Behavioral Characteristics and Self-Reported Health Status among 2029 Adults Consuming a “Carnivore Diet” Open
Contrary to common expectations, adults consuming a carnivore diet experienced few adverse effects and instead reported health benefits and high satisfaction. Cardiovascular disease risk factors were variably affected. The generalizability…
View article: The breath print represents a novel biomarker of malnutrition in pulmonary arterial hypertension: A proof of concept study
The breath print represents a novel biomarker of malnutrition in pulmonary arterial hypertension: A proof of concept study Open
Background The breath print is a quantitative measurement of molecules in exhaled breath and represents a new frontier for biomarker identification. It is unknown whether this state‐of‐the‐art, noninvasive method can detect malnutrition. W…
View article: A Whole-Grain Diet Increases Whole-Body Protein Balance Compared with a Macronutrient-Matched Refined-Grain Diet
A Whole-Grain Diet Increases Whole-Body Protein Balance Compared with a Macronutrient-Matched Refined-Grain Diet Open
View article: Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans Open
View article: Resting Energy Expenditure Is Elevated in Asthma
Resting Energy Expenditure Is Elevated in Asthma Open
Background: Asthma physiology affects respiratory function and inflammation, factors that may contribute to elevated resting energy expenditure (REE) and altered body composition. Objective: We hypothesized that asthma would present with e…
View article: Calorie Restriction and Aging in Humans
Calorie Restriction and Aging in Humans Open
Calorie restriction (CR), the reduction of dietary intake below energy requirements while maintaining optimal nutrition, is the only known nutritional intervention with the potential to attenuate aging. Evidence from observational, preclin…
View article: BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control
BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control Open
Obesity is a leading cause of preventable death worldwide. Despite this, current strategies for the treatment of obesity remain ineffective at achieving long-term weight control. This is due, in part, to difficulties in identifying tolerab…
View article: A Whole-Grain Diet Improves Whole-Body Protein Turnover Compared to a Macronutrient-Matched Refined-Grain Diet in Adults with Overweight/Obesity
A Whole-Grain Diet Improves Whole-Body Protein Turnover Compared to a Macronutrient-Matched Refined-Grain Diet in Adults with Overweight/Obesity Open
View article: Growth Differentiation Factor 15 Is Linked to Reduced Preference for Fatty Foods in Adults with Overweight or Obesity
Growth Differentiation Factor 15 Is Linked to Reduced Preference for Fatty Foods in Adults with Overweight or Obesity Open
OBJECTIVES: Growth differentiation factor 15 (GDF15) reduces food intake, dietary fat preference, and body weight in pre-clinical studies. Through recent human and in vitro studies, we have identified a role for GDF15 in the energy expendi…
View article: β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro
β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro Open
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation and impaired insulin sensitivity. Reduced hepatic ketogenesis may promote these pathologies, but data are inconclusive in humans and the link between NAF…
View article: Rationale and study design for lifestyle intervention in preparation for pregnancy (LIPP): A randomized controlled trial
Rationale and study design for lifestyle intervention in preparation for pregnancy (LIPP): A randomized controlled trial Open
View article: Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes
Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes Open
Purpose Disruption of the skeletal muscle molecular clock leads to metabolic disease, whereas exercise may be restorative, leading to improvements in metabolic health. The purpose of this study was to evaluate the effects of a 12-wk exerci…
View article: Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study
Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study Open
Individuals with idiopathic pulmonary arterial hypertension (PAH) display reduced oral glucose tolerance. This may involve defects in pancreatic function or insulin sensitivity but this hypothesis has not been tested; moreover, fasting nut…
View article: Plasma metabolomic profile in chronic thromboembolic pulmonary hypertension
Plasma metabolomic profile in chronic thromboembolic pulmonary hypertension Open
We aimed to characterize the plasma metabolome of chronic thromboembolic pulmonary hypertension patients using a high-throughput unbiased omics approach. We collected fasting plasma from a peripheral vein in 33 operable chronic thromboembo…