Explanipedia

Nationwide study on forensic genetic analyses in criminal cases in Denmark Open

Olivia Strunge Meyer, Frederik Torp Petersen, Bo Thisted Simonsen, Jacob Tfelt‐Hansen, Claus Børsting · 2025

Historically, forensic genetics research has focused on increasing sensitivity of DNA analyses, improving mixture profile deconvolution, and advancing forensic DNA intelligence methodologies. The aim of this study was to quantify the relev…

DNA methylation alterations of <i>PITX2</i> and <i>PANCR</i> are associated with left-right asymmetry of the heart and left ventricle size Open

Steffan Noe Niikanoff Christiansen, Kristine Boisen Olsen, Sara Tangmose Larsen, Pernille Heimdal Holm, Marie Kroman Palsøe , et al. · 2025

1 Abstract Background Postmortem genetic testing is a crucial tool to determine the cause of sudden cardiac death and to allow family testing of relatives. While DNA variants are extensively studied in sudden cardiac death, the role of DNA…

The Clinical Significance of Atrial Fibrillation in Non–High-Risk Brugada Syndrome Open

Marco Bergonti, Frédéric Sacher, Bernard Belhassen, Geòrgia Sarquella-Brugada, Elena Arbelo , et al. · 2025

The presence of AF in non-high-risk BrS does not identify patients with higher risk of VAs. However, early-onset AF (<20 years) defines a distinct subgroup with elevated risk. Patients with AF and BrS have a significantly higher risk of SS…

Evaluation of the HumanMethylationEPIC v2.0 Bead Chip Using Low Quality and Quantity DNA Samples Open

Brando Poggiali, Mikkel Eriksen Dupont, Marie‐Louise Kampmann, Athina Vidaki, Vânia Pereira , et al. · 2025

Both DNA fragment size and DNA input amounts affect DNAm analysis on the EPIC v2.0, with the investigated DNA fragment size having a greater impact than the investigated DNA input amount. DNAm measurements were achieved with the EPIC v2.0 …

Sudden unexplained death in individuals with and without epilepsy Open

Marie Kroman Palsøe, Carl Johann Hansen, Christian Torp‐Pedersen, Kristían Línnet, Marius Kløvgaard , et al. · 2025

SUDEP cases are more frequently unwitnessed, involve individuals living alone, and are associated with psychiatric comorbidities than SUDs without epilepsy. Enhancing psychiatric care and supervision for individuals with epilepsy may reduc…

Cardiac arrest while using the toilet: not uncommon and associated with adverse resuscitation profile Open

E. Paratz, Carl Johann Hansen, André La Gerche, Dion Stub, Emily Nehme , et al. · 2025

Speckle tracking echocardiography for prediction of arrhythmias in idiopathic ventricular fibrillation Open

Rasmus B Dinesen, Ulrik Winsløw, Michael Vinther, Berit T. Philbert, Tor Biering‐Sørensen , et al. · 2025

Aims Individuals experiencing a sudden cardiac arrest with ventricular fibrillation and no identifiable cause are diagnosed with idiopathic ventricular fibrillations (IVFs). 2D speckle tracking echocardiography (2DSTE) has been able to det…

Diagnostic yield in families to sudden cardiac death victims: a 10-year follow-up study Open

Christine Louise Grønholdt, Benjamin Lautrup Hansen, Fredrik Folke, Trine K. Lauridsen, Anna Axelsson Raja , et al. · 2025

Aims Up to 70% of sudden cardiac death (SCD) cases in younger individuals are potentially caused by an inherited heart disease. However, long-term diagnostic yield and risk of cardiac events in SCD relatives remain unclear. This study aime…

Machine learning approach for automated localization of ventricular tachycardia ablation targets from substrate maps: development and validation in a porcine model Open

Xuezhe Wang, Adam Dennis, Eva Melis Hesselkilde, Arnela Saljic, Benedikt M. Linz , et al. · 2025

Aims The recurrence rate of ventricular tachycardia (VT) after ablation remains high due to the difficulty in locating VT critical sites. This study proposes a machine learning approach for improved identification of ablation targets based…

RNA degradation patterns in cardiac tissues kept at different time intervals and temperatures before RNA sequencing Open

Stine Bøttcher Jacobsen, Jacob Tfelt‐Hansen, Morten Smerup, Niels Morling, Jeppe Dyrberg Andersen · 2025

Vast repositories of tissues are available in biobanks worldwide. For these tissues to be used for molecular investigations, such as gene expression analysis, it is important to understand the limitations of pre-analytical variables. Stora…

Impact of atrial fibrillation on cardiac arrest: a nationwide cohort study Open

Deepthi Rajan, Peder Emil Warming, Bo Gregers Winkel, Rodrigue Garcia, Fredrik Folke , et al. · 2025

Background Atrial fibrillation (AF) is the most common heart rhythm disorder and cardiac arrest (CA) is one of the leading causes of death. Growing evidence indicates an association between AF and CA.[1-2] However, research into the correl…

A 10-year follow-up study on diagnostic yield in families of sudden cardiac death patients Open

Christine Groenholdt, Benjamin L Hansen, Fredrik Folke, Trine K. Lauridsen, Anna Axelsson Raja , et al. · 2025

Background Sudden cardiac death (SCD) accounts for 10-20% of all deaths in Western countries, and inherited cardiac diseases account for a significant proportion of SCD. Despite being a major public health issue with a profound impact on a…

aTrial arrhythmias in inhEriTed aRrhythmIa Syndromes: results from the TETRIS study Open

Marco Bergonti, Vincent Probst, Hiroshi Morita, Jacob Tfelt‐Hansen, Elijah R. Behr , et al. · 2025

Background Little is known about the distribution and clinical course of patients with inherited arrhythmia syndrome (IAS) and concomitant atrial arrhythmias (AAs). Aim 1) To characterize the distribution of AAs in patients with IAS and 2)…

The impact of length of antidepressant use on risk of sudden cardiac death Open

Jasmin Mujkanovic, Peder Emil Warming, Lars Vedel Kessing, L Koeber, Bo Gregers Winkel , et al. · 2025

Background Patients with psychiatric disorders have an increased all-cause mortality as well as an increased risk for sudden cardiac death (SCD) across all age groups. We have previously shown that patients with depressive disorders had a …

Evaluation of the HumanMethylationEPIC v2.0 Bead Chip using low quality and quantity DNA samples Open

Brando Poggiali, Mikkel Eriksen Dupont, Marie‐Louise Kampmann, Athina Vidaki, Vânia Pereira , et al. · 2025

Background: The HumanMethylationEPIC v2.0 BeadChip (EPIC v2.0) microarray is a widely used tool for genome-wide DNA methylation (DNAm) analysis, designed for high-quality human DNA with a recommended input of 250 ng. However, in clinical a…

Assessment of antiseizure medication adherence based on postmortem toxicology and claimed prescriptions in cases of sudden unexpected death in epilepsy Open

Marie Kroman Palsøe, Carl Johann Hansen, Christian Torp‐Pedersen, Kristían Línnet, Marius Kløvgaard , et al. · 2025

Objective Individuals with epilepsy are at a higher risk of dying suddenly and without explanation, known as sudden unexpected death in epilepsy (SUDEP). Seizures are a risk factor for SUDEP, and nonadherence to antiseizure medication (ASM…

Arrhythmias and Sudden Death: What is New in Hypertrophic Cardiomyopathy? Open

Deepthi Rajan, Christopher Ryan Zörner, Morten Lock Hansen, Jacob Tfelt‐Hansen · 2025

Hypertrophic cardiomyopathy (HCM) is a complex genetic disorder that has garnered significant attention because of its diverse manifestations, including arrhythmias and heightened risk of sudden cardiac death. Advances in precision diagnos…

Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology Open

José Luís Merino, Juan Tamargo, Carina Blomström‐Lundqvist, Giuseppe Boriani, Harry J.G.M. Crijns , et al. · 2025

The European Heart Rhythm Association Practical Compendium of Anti-arrhythmic Drugs (AADs) offers advice on these drugs, focusing on their clinical use and the global impact of cardiac arrhythmias. This document aims to provide practical i…

The diagnostic role of pharmacological provocation testing in cardiac electrophysiology: a clinical consensus statement of the European Heart Rhythm Association and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC, the ESC Working Group on Cardiovascular Pharmacotherapy, the Association of European Paediatric and Congenital Cardiology (AEPC), the Paediatric & Congenital Electrophysiology Society (PACES), the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS) Open

Elijah R. Behr, Bo Gregers Winkel, Bode Ensam, Alberto Alfie, Elena Arbelo , et al. · 2025

The pharmacological provocation test is a pivotal tool in cardiac electrophysiology for the diagnosis of potential causes of sudden cardiac death, sudden cardiac arrest (SCA), arrhythmias, symptoms, or ECG abnormalities. The 2022 European …

Baseline and 10-year change in the number of ideal cardiovascular health metrics and sudden cardiac death in the community Open

Jean‐Philippe Empana, M. C. Perier, Peder Emil Warming, Éloi Marijon, Irene G. M. van Valkengoed , et al. · 2025

Aims Adherence to an ideal cardiovascular health (CVH) might contribute to lower the burden of sudden cardiac death (SCD) in the community. We aimed to examine the association between the number of ideal CVH metrics at baseline and of its …

Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest Open

Magnus Gylling, Johanna Krøll, Peder Emil Warming, Carolina Malta Hansen, Fredrik Folke , et al. · 2025

A family history of CVD and death is more common among patients with OHCA compared to a matched background population, as well as being significantly associated with OHCA.

Socio-economic position and sudden cardiac death: a Danish nationwide study Open

T Jacobsen, Tobias Skjelbred, Lars Køber, Bo Gregers Winkel, Thomas Hadberg Lynge , et al. · 2025

Aims The aim of this study was to examine differences in incidence rates of all-cause mortality (ACM) and sudden cardiac death (SCD) in persons of differing socio-economic position (SEP). Methods and results All deaths in Denmark from 1 Ja…

Independent evaluation of an 11-CpG panel for age estimation in blood Open

Mie Rath Refn, Marie‐Louise Kampmann, Agnes Vyöni, Jacob Tfelt‐Hansen, Erik Sørensen , et al. · 2024

DNA methylation patterns have emerged as reliable markers for age estimation, offering potential applications in forensic investigations, namely, in cases where there is no information about a possible suspect, in the identification of vic…

Novel risk predictor of arrhythmias for patients with potassium channel–related congenital long QT syndrome Open

Christian Krijger Juárez, V M Proost, Michael W.T. Tanck, Sven Dittmann, J. Martijn Bos , et al. · 2024

aTrial arrhythmias in inhEriTed aRrhythmIa Syndromes: results from the TETRIS study Open

Giulio Conte, Marco Bergonti, Vincent Probst, Hiroshi Morita, Jacob Tfelt‐Hansen , et al. · 2024

Aims Little is known about the distribution and clinical course of patients with inherited arrhythmia syndrome (IAS) and concomitant atrial arrhythmias (AAs). The aim of the study is (i) to characterize the distribution of AAs in patients …

DNA methylation stability in cardiac tissues kept at different temperatures and time intervals Open

Brando Poggiali, Mikkel Eriksen Dupont, Stine Bøttcher Jacobsen, Morten Smerup, Steffan Noe Niikanoff Christiansen , et al. · 2024

Nationwide burden of sudden cardiac death among patients with a psychiatric disorder Open

Jasmin Mujkanovic, Peder Emil Warming, Lars Vedel Kessing, Lars Køber, Bo Gregers Winkel , et al. · 2024

Background Patients with psychiatric disorders have increased all-cause mortality compared with the general population. Previous research has shown that there is a fourfold increased risk of sudden cardiac death (SCD) among the young. Obje…

Hereditary heart diseases and sudden cardiac death Open

Priya Bhardwaj, Bo Gregers Winkel, Finn Lund Henriksen, Jacob Tfelt‐Hansen, Jasmin Mujkanovic , et al. · 2024

Up to 70% of all sudden cardiac deaths (SCD) in persons under 50 years are due to inherited cardiovascular diseases. First-degree relatives to younger SCD patients should be evaluated for inherited cardiovascular disease, as argued in this…

Sudden cardiac death after myocardial infarction: individual participant data from pooled cohorts Open

Niels Peek, Gerhard Hindricks, Artur Akbarov, Jan G.P. Tijssen, David Jenkins , et al. · 2024

Background and Aims Risk stratification of sudden cardiac death after myocardial infarction and prevention by defibrillator rely on left ventricular ejection fraction (LVEF). Improved risk stratification across the whole LVEF range is requ…

International collaboration as a turning point for sudden cardiac arrest prediction and treatment: the PARQ COST Action Open

Hanno L. Tan, Enrico Baldi, Martin Jönsson, Jacob Tfelt‐Hansen · 2024

International collaboration as a turning point for sudden cardiac arrest prediction and treatment: the PARQ COST Action PARQ aims to create a network of researchers across Europe whose overall aim is to reduce the societal burden of sudden…

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