Jacob Torgersen
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View article: Development and characterisation of a novel cell line derived from coho salmon (Oncorhynchus kisutch)
Development and characterisation of a novel cell line derived from coho salmon (Oncorhynchus kisutch) Open
Coho salmon ( Oncorhynchus kisutch ) is an important salmonid species differing from other salmonids in its tolerance and response to pathogens endemic to the aquaculture industry, such as infectious pancreatic necrosis virus (IPNV) and in…
View article: Establishment of a genetically amenable fibroblast cell line from Atlantic salmon skin
Establishment of a genetically amenable fibroblast cell line from Atlantic salmon skin Open
The Atlantic salmon, Salmo Salar, is a societally important species of fish, both as a food source and as a component of aquatic biosphere. Its sustainable production is hampered by a wide range of infectious diseases, which is difficult t…
View article: Exploring the Use of Alternative Promoters for Enhanced Transgene and sgRNA Expression in Atlantic Salmon Cells
Exploring the Use of Alternative Promoters for Enhanced Transgene and sgRNA Expression in Atlantic Salmon Cells Open
This study facilitates design of expression vectors and lentivirus tools for gene editing of Atlantic salmon. We have characterized widely used heterologous promoters and novel endogenous promoters in Atlantic salmon cells. We used qPCR to…
View article: Exploring the use of alternative promoters for enhanced transgene and sgRNA expression in Atlantic salmon cells
Exploring the use of alternative promoters for enhanced transgene and sgRNA expression in Atlantic salmon cells Open
This study facilitates design of expression vectors and lentivirus tools for gene editing of Atlantic salmon. We have characterized widely used heterologous promoters and novel endogenous promoters in Atlantic salmon cells. We used qPCR to…
View article: Efficient transfection of Atlantic salmon primary hepatocyte cells for functional assays and gene editing
Efficient transfection of Atlantic salmon primary hepatocyte cells for functional assays and gene editing Open
The expansion of genomic resources for Atlantic salmon over the past half decade has enabled efficient interrogation of genetic traits by large-scale correlation of genotype to phenotype. Moving from correlation to causation will require g…
View article: Efficient transfection of Atlantic salmon primary hepatocyte cells for functional assays and gene editing
Efficient transfection of Atlantic salmon primary hepatocyte cells for functional assays and gene editing Open
The expansion of genomic resources for Atlantic salmon over the past half decade has enabled efficient interrogation of genetic traits by large-scale correlation of genotype to phenotype. Moving from correlation to causation will require g…
View article: Immersion challenge model for <i>Flavobacterium psychrophilum</i> infection of Atlantic salmon (<i>Salmo salar</i> L.) fry
Immersion challenge model for <i>Flavobacterium psychrophilum</i> infection of Atlantic salmon (<i>Salmo salar</i> L.) fry Open
Flavobacterium psychrophilum is the causative agent of bacterial cold‐water disease (CWBD) and rainbow trout fry syndrome (RTFS), which affect salmonids. To better understand this pathogen and its interaction with the host during infection…
View article: DHA Modulates Immune Response and Mitochondrial Function of Atlantic Salmon Adipocytes after LPS Treatment
DHA Modulates Immune Response and Mitochondrial Function of Atlantic Salmon Adipocytes after LPS Treatment Open
Adipocytes play a central role in overall energy homeostasis and are important contributors to the immune system. Fatty acids (FAs) act as signaling molecules capable to modulate adipocyte metabolism and functions. To identify the effects …
View article: Lipid Deposition and Mobilisation in Atlantic Salmon Adipocytes
Lipid Deposition and Mobilisation in Atlantic Salmon Adipocytes Open
The present study aimed to elucidate how Atlantic salmon adipocytes pre-enriched with palmitic (16:0, PA), oleic (18:1n−9, OA), or eicosapentaenoic (20:5n−3, EPA) acid respond to a fasting condition mimicked by nutrient deprivation and glu…
View article: Targeted mutagenesis of Δ5 and Δ6 fatty acyl desaturases induce multiplex-mutagenesis and lipogenesis in Atlantic salmon (<i>Salmo salar</i>)
Targeted mutagenesis of Δ5 and Δ6 fatty acyl desaturases induce multiplex-mutagenesis and lipogenesis in Atlantic salmon (<i>Salmo salar</i>) Open
With declining wild fish populations, farmed Atlantic salmon ( Salmo salar ) has gained popularity as a source for healthy long-chain highly unsaturated fatty acids (LC-HUFA) including 20:5n-3 and 22:6n-3. However, the introduction of plan…
View article: Additional file 3 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar)
Additional file 3 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar) Open
(CSV 3 kb)
View article: Additional file 1 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar)
Additional file 1 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar) Open
(XLSX 608 kb)
View article: Additional file 2 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar)
Additional file 2 of Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar) Open
(CSV 61 kb)
View article: Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color Open
Red coloration of muscle tissue (flesh) is a unique trait in several salmonid genera, including Atlantic salmon. The color results from dietary carotenoids deposited in the flesh, whereas the color intensity is affected both by diet and ge…
View article: Genomic and functional gene studies suggest a key role of <i>beta-carotene oxygenase 1 like (bco1l)</i> gene in salmon flesh color
Genomic and functional gene studies suggest a key role of <i>beta-carotene oxygenase 1 like (bco1l)</i> gene in salmon flesh color Open
Red coloration of muscle tissue (flesh) is a unique trait in several salmonid genera, including Atlantic salmon. The color results from dietary carotenoids deposited in the flesh, whereas the color intensity is affected both by diet and ge…
View article: Peer Review #2 of "Liver slice culture as a model for lipid metabolism in fish (v0.1)"
Peer Review #2 of "Liver slice culture as a model for lipid metabolism in fish (v0.1)" Open
Hepatic lipid metabolism is traditionally investigated in vitro using hepatocyte monocultures lacking the complex three-dimensional structure and interacting cell types essential liver function.Precision cut liver slice (PCLS) culture repr…
View article: Liver slice culture as a model for lipid metabolism in fish
Liver slice culture as a model for lipid metabolism in fish Open
Hepatic lipid metabolism is traditionally investigated in vitro using hepatocyte monocultures lacking the complex three-dimensional structure and interacting cell types essential liver function. Precision cut liver slice (PCLS) culture rep…
View article: Peer Review #1 of "Liver slice culture as a model for lipid metabolism in fish (v0.1)"
Peer Review #1 of "Liver slice culture as a model for lipid metabolism in fish (v0.1)" Open
Hepatic lipid metabolism is traditionally investigated in vitro using hepatocyte monocultures lacking the complex three-dimensional structure and interacting cell types essential liver function.Precision cut liver slice (PCLS) culture repr…
View article: Peer Review #2 of "Liver slice culture as a model for lipid metabolism in fish (v0.2)"
Peer Review #2 of "Liver slice culture as a model for lipid metabolism in fish (v0.2)" Open
Hepatic lipid metabolism is traditionally investigated in vitro using hepatocyte monocultures lacking the complex three-dimensional structure and interacting cell types essential liver function.Precision cut liver slice (PCLS) culture repr…
View article: Additional file 4: of Transcriptional development of phospholipid and lipoprotein metabolism in different intestinal regions of Atlantic salmon (Salmo salar) fry
Additional file 4: of Transcriptional development of phospholipid and lipoprotein metabolism in different intestinal regions of Atlantic salmon (Salmo salar) fry Open
Table S1. Result of differential expression ananlysis on all genes in stomach, pyloric caeca and hindgut of 2.5 and 10 g salmon both compared to 0.16 g. (XLSX 14268 kb)
View article: Additional file 5: of Transcriptional development of phospholipid and lipoprotein metabolism in different intestinal regions of Atlantic salmon (Salmo salar) fry
Additional file 5: of Transcriptional development of phospholipid and lipoprotein metabolism in different intestinal regions of Atlantic salmon (Salmo salar) fry Open
Table S1. Result of KEGG ontology enrichment analysis on differential expressed genes (DEG) in stomach, pyloric caeca and hindgut of 0.16 and 2.5 g salmon both compared to 0.16 g. (XLSX 65 kb)
View article: Transcriptional development of phospholipid and lipoprotein metabolism in different intestinal regions of Atlantic salmon (<i>Salmo salar</i>) fry
Transcriptional development of phospholipid and lipoprotein metabolism in different intestinal regions of Atlantic salmon (<i>Salmo salar</i>) fry Open
Background It has been suggested that the high phospholipid (PL) requirement in Atlantic salmon ( Salmo salar ) fry is due to insufficient intestinal de-novo synthesis causing low lipoprotein (LP) production and reduced transport capacity …
View article: Life stage associated remodeling of lipid metabolism regulation in the duplicated Atlantic salmon genome
Life stage associated remodeling of lipid metabolism regulation in the duplicated Atlantic salmon genome Open
Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. These habitat shifts require great phenotypic plasticity. To address the unresolved question of how the shift in diet bet…
View article: Epithelial Cadherin Determines Resistance to Infectious Pancreatic Necrosis Virus in Atlantic Salmon
Epithelial Cadherin Determines Resistance to Infectious Pancreatic Necrosis Virus in Atlantic Salmon Open
Infectious pancreatic necrosis virus (IPNV) is the cause of one of the most prevalent diseases in farmed Atlantic salmon (Salmo salar). A quantitative trait locus (QTL) has been found to be responsible for most of the genetic variation in …
View article: Metabolism, health and fillet nutritional quality in Atlantic salmon (<i>Salmo salar</i>) fed diets containing <i>n</i>-3-rich microalgae
Metabolism, health and fillet nutritional quality in Atlantic salmon (<i>Salmo salar</i>) fed diets containing <i>n</i>-3-rich microalgae Open
Microalgae, as primary producers of EPA and DHA, are among the most prominent alternative sources to fish oil for n -3 long-chain PUFA in animal and human nutrition. The present study aimed to assess technical, nutritional and fish health …