Jacobijn Gussekloo
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View article: Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts
Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts Open
Objective The association of thyroid peroxidase antibodies (TPOAb) status with cardiovascular disease (CVD) risk, independent of thyroid function, remains unclear. We aimed to determine whether positive TPOAb is associated with increased C…
View article: Comparison of diagnostic algorithms used in guidelines on nutritional anaemias in adults
Comparison of diagnostic algorithms used in guidelines on nutritional anaemias in adults Open
Background Anaemia is highly prevalent and commonly caused by nutritional deficiencies. Guidelines often include an algorithm to find the underlying cause. Here, we compared diagnostic algorithms and suggested laboratory tests for anaemia …
View article: SUN-256 Is Thyroid Antibody Testing Useful to Predict the Risk of Coronary Heart Disease and Stroke Independently of Thyroid Function? An Individual Participant Data Analysis.
SUN-256 Is Thyroid Antibody Testing Useful to Predict the Risk of Coronary Heart Disease and Stroke Independently of Thyroid Function? An Individual Participant Data Analysis. Open
Disclosure: O. Hysaj: None. O. Efthimiou: None. T. Collet: None. A.R. Cappola: None. F. Azizi: None. A. Köttgen: None. E. Selvin: None. L. Chacker: None. R. P. Peeters: None. S. Trompet: None. J. Gussekloo: None. J. Walsh: None. S. Brown: …
View article: Prescriptions of Essentially Placebo Treatments Among General Practitioners in 21 Countries
Prescriptions of Essentially Placebo Treatments Among General Practitioners in 21 Countries Open
Importance General practitioners (GPs) sometimes initiate a treatment despite not expecting it to improve patients’ symptoms by any physiological mechanism. These essentially placebo treatments are ethically controversial, and their freque…
View article: Initiation of anti-osteoporosis medication following hip fracture in older adults: a systematic review and thematic synthesis of qualitative studies from patient and healthcare professional perspectives
Initiation of anti-osteoporosis medication following hip fracture in older adults: a systematic review and thematic synthesis of qualitative studies from patient and healthcare professional perspectives Open
Background Pharmacological osteoporosis treatment is recommended for secondary fracture prevention in older patients following a hip fracture. However, not all eligible patients receive anti-osteoporosis medication (AOMs). Understanding th…
View article: Is frailty incremental to the 4C Mortality model for mortality risk prediction in hospitalized older individuals with COVID-19 disease?
Is frailty incremental to the 4C Mortality model for mortality risk prediction in hospitalized older individuals with COVID-19 disease? Open
Frailty reflected by CFS demonstrated limited incremental value for in-hospital mortality prediction in addition to validated 4C Mortality model. Future research should explore other predictors that capture heterogeneity in older populatio…
View article: Effecten van het afbouwen van antihypertensiva op neuropsychiatrische symptomen en kwaliteit van leven in verpleeghuisbewoners met dementie (DANTON): een multicenter, open-label, uitkomst-geblindeerde, gerandomiseerde studie.
Effecten van het afbouwen van antihypertensiva op neuropsychiatrische symptomen en kwaliteit van leven in verpleeghuisbewoners met dementie (DANTON): een multicenter, open-label, uitkomst-geblindeerde, gerandomiseerde studie. Open
Background The benefit-harm balance of antihypertensive treatment in older adults with advanced dementia is unclear. This study assesses whether discontinuing antihypertensive treatment reduces neuropsychiatric symptoms (NPS) and maintains…
View article: Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study
Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study Open
View article: Validation of the acutely presenting older patient screener for short term mortality prediction in older patients hospitalized for COVID-19
Validation of the acutely presenting older patient screener for short term mortality prediction in older patients hospitalized for COVID-19 Open
View article: Associations between metabolomic scores and clinical outcomes in hospitalized COVID-19 patients
Associations between metabolomic scores and clinical outcomes in hospitalized COVID-19 patients Open
View article: A qualitative study regarding older people’s goals of care in relation to frailty status: finding meaning in ‘smaller things’ in life
A qualitative study regarding older people’s goals of care in relation to frailty status: finding meaning in ‘smaller things’ in life Open
Background Increasingly frailty assessment is part of the shared decision-making process of older patients. However, little is known of the role of frailty in goals of care among the diverse group of older persons. Objective To explore the…
View article: Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease
Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease Open
Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vulnerabili…
View article: Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Results of a European Delphi studyFor the DELPHI Serenity Group
Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Results of a European Delphi studyFor the DELPHI Serenity Group Open
View article: The influence of the dynamic context of the pandemic on the predictive performance of mortality predictions over time in older patients hospitalized for COVID-19
The influence of the dynamic context of the pandemic on the predictive performance of mortality predictions over time in older patients hospitalized for COVID-19 Open
Compared to the moderate model performance in the first wave, we observed a slight decrease in terms of discrimination and calibration in the second and third wave with a much larger decrease in the fourth wave. This highlights the importa…
View article: Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex
Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex Open
Context Subclinical thyroid dysfunction (ScTD), comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper), has been associated with increased risk for cardiovascular events. Objective To assess associations bet…
View article: Placebo Prescriptions among General Practitioners in 21 Countries: the PURE Questionnaire
Placebo Prescriptions among General Practitioners in 21 Countries: the PURE Questionnaire Open
Objectives. General practitioners (GPs) sometimes initiate a treatment despite not expecting it will improve patients’ symptoms by any known physiological mechanism. The frequency, risks, and ethics of these essentially placebo treatments …
View article: Risk assessment and management strategies in older patients with acute pulmonary embolism
Risk assessment and management strategies in older patients with acute pulmonary embolism Open
Selecting for home treatment using Hestia criteria was safe for older patients with PE in our cohort. Mortality in the high-risk group was high also when receiving reperfusion treatment. The European Society of Cardiology risk classificati…
View article: Professional identity formation of medical students in relation to older persons’ healthcare: exploring the views of older persons living in the Netherlands – a qualitative study
Professional identity formation of medical students in relation to older persons’ healthcare: exploring the views of older persons living in the Netherlands – a qualitative study Open
Objectives Given the growing population of older persons, medical students need to develop an appropriate professional identity to comply with older persons’ healthcare needs. In this study, we explored the needs and expectations of older …
View article: The association of inflammatory markers with frailty and in-hospital mortality in older COVID-19 patients
The association of inflammatory markers with frailty and in-hospital mortality in older COVID-19 patients Open
View article: Effects of the discontinuation of antihypertensive treatment on neuropsychiatric symptoms and quality of life in nursing home residents with dementia (DANTON): a multicentre, open-label, blinded-outcome, randomised controlled trial
Effects of the discontinuation of antihypertensive treatment on neuropsychiatric symptoms and quality of life in nursing home residents with dementia (DANTON): a multicentre, open-label, blinded-outcome, randomised controlled trial Open
Background Based on observational studies and randomised controlled trials (RCTs), the benefit–harm balance of antihypertensive treatment in older adults with dementia is unclear. Objective To assess whether discontinuing antihypertensive …
View article: Temporal dynamics of depressive symptoms and cognitive decline in the oldest old: dynamic time warp analysis of the Leiden 85-plus study
Temporal dynamics of depressive symptoms and cognitive decline in the oldest old: dynamic time warp analysis of the Leiden 85-plus study Open
Background The prevalence of depressive symptoms and cognitive decline increases with age. We investigated their temporal dynamics in individuals aged 85 and older across a 5-year follow-up period. Methods Participants were selected from t…
View article: Preparing for future pandemics: frailty associates with mortality in hospitalised older people during the entire COVID-19 pandemic, a Dutch multicentre cohort study
Preparing for future pandemics: frailty associates with mortality in hospitalised older people during the entire COVID-19 pandemic, a Dutch multicentre cohort study Open
View article: A systematic review of subclinical hyperthyroidism guidelines: a remarkable range of recommendations
A systematic review of subclinical hyperthyroidism guidelines: a remarkable range of recommendations Open
Background Subclinical thyroid diseases are often the subject of debate concerning their clinical significance, the appropriateness of diagnostic testing, and possible treatment. This systematic review addresses the variation in internatio…
View article: Older people’s goals of care in relation to frailty status—the COOP-study
Older people’s goals of care in relation to frailty status—the COOP-study Open
Background Literature relating older people’s goals of care to their varying frailty status is scarce. Objective To investigate goals of care in case of acute and/or severe disease in relationship to frailty status among the general older …
View article: Lifestyle and incident dementia: A COSMIC individual participant data meta‐analysis
Lifestyle and incident dementia: A COSMIC individual participant data meta‐analysis Open
INTRODUCTION The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dem…
View article: Temporal Dynamics of Depressive Symptoms and Cognitive Decline in the Oldest Old: Dynamic Time Warp analysis of the Leiden 85-plus Study
Temporal Dynamics of Depressive Symptoms and Cognitive Decline in the Oldest Old: Dynamic Time Warp analysis of the Leiden 85-plus Study Open
Introduction The prevalence of depressive symptoms and cognitive decline increases with age, reducing quality of life. However, the temporal relationship between the two remains elusive. Objectives We aimed to explore the temporal relation…
View article: Table of Contents
Table of Contents Open
View article: Limited incremental predictive value of the frailty index and other vulnerability measures from routine care data for mortality risk prediction in older patients with COVID-19 in primary care
Limited incremental predictive value of the frailty index and other vulnerability measures from routine care data for mortality risk prediction in older patients with COVID-19 in primary care Open
View article: External validation of six COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting
External validation of six COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting Open
Our results show that most prognostic models for predicting mortality risk performed poorly in the older population with COVID-19, in each health-care setting: hospital, primary care, and nursing home settings. Insights into factors influe…
View article: Association of low blood pressure and falls: An analysis of data from the Leiden 85-plus Study
Association of low blood pressure and falls: An analysis of data from the Leiden 85-plus Study Open
Background Falls and consequent injuries are prevalent in older adults. In this group, half of injury-related hospitalizations are associated with falls and the rate of falls increases with age. The evidence on the role of blood pressure a…