Jacqueline Darrow
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View article: CSF Alzheimer Disease Biomarkers
CSF Alzheimer Disease Biomarkers Open
The lengthy follow-up of BIOCARD participants permitted an examination of time-varying associations between CSF AD biomarkers with MCI symptom onset and the influence of sex, baseline age, and ApoE4 genotype on these associations. These fa…
View article: CSF Biomarkers Predict Gait Outcomes in Idiopathic Normal Pressure Hydrocephalus
CSF Biomarkers Predict Gait Outcomes in Idiopathic Normal Pressure Hydrocephalus Open
A combination of CSF biomarkers can predict improvement following shunt surgery for iNPH. However, these measures only modestly discriminate responders from nonresponders following CSF TT. The findings further suggest that abnormal CSF bio…
View article: Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease
Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease Open
Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early biomarker in human cognitive impairment. However, the relationship between BBB breakdown and brain pathology, most commonly Alzheimer disease (AD) and vascular…
View article: Cerebrospinal fluid lipidomics for biomarkers of Alzheimer's disease
Cerebrospinal fluid lipidomics for biomarkers of Alzheimer's disease Open
Cerebrospinal fluid lipid biomarkers of Alzheimer's disease were discovered using tandem mass spectrometry.
View article: Effect of Patient-Specific Preanalytic Variables on CSF Aβ1–42 Concentrations Measured on an Automated Chemiluminescent Platform
Effect of Patient-Specific Preanalytic Variables on CSF Aβ1–42 Concentrations Measured on an Automated Chemiluminescent Platform Open
Background Cerebrospinal fluid (CSF) biomarkers are increasingly used to confirm the accuracy of a clinical diagnosis of mild cognitive impairment or dementia due to Alzheimer disease (AD). Recent evidence suggests that fully automated ass…
View article: Quantitative proteomic analysis of the frontal cortex in Alzheimer’s disease
Quantitative proteomic analysis of the frontal cortex in Alzheimer’s disease Open
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by intracellular formation of neurofibrillary tangles and extracellular deposition of β‐amyloid protein (Aβ) in the extracellular matrix. The pathogenesis of AD …
View article: Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases
Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases Open
Background Alzheimer's disease and vascular cognitive impairment (VCI), as well as their concurrence, represent the most common types of cognitive dysfunction. Treatment strategies for these two conditions are quite different; however, the…
View article: Multiplexed Phosphoproteomic Study of Brain in Patients with Alzheimer's Disease and Age-Matched Cognitively Healthy Controls
Multiplexed Phosphoproteomic Study of Brain in Patients with Alzheimer's Disease and Age-Matched Cognitively Healthy Controls Open
Alzheimer's disease (AD) is the most common neurodegenerative disorder caused by neuronal loss that results in cognitive and functional impairment. Formation of neurofibrillary tangles composed of abnormal hyperphosphorylation of tau prote…
View article: P4‐476: EFFECT OF PATIENT‐SPECIFIC PRE‐ANALYTIC VARIABLES ON CSF Aβ42 CONCENTRATIONS MEASURED ON AN AUTOMATED CHEMILUMINESCENT PLATFORM
P4‐476: EFFECT OF PATIENT‐SPECIFIC PRE‐ANALYTIC VARIABLES ON CSF Aβ42 CONCENTRATIONS MEASURED ON AN AUTOMATED CHEMILUMINESCENT PLATFORM Open
Cerebrospinal fluid (CSF) biomarker concentrations are valuable in the diagnosis of Alzheimer's Disease (AD). CSF β-amyloid 1–42 (Aβ42), is a core biomarker of AD. While analytic variability has been reduced with the advent of automated as…