Jacqueline Deen
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View article: Leveraging optimized oligonucleotide-tagged antigen assemblies and single-cell sequencing for multiplexed proteogenomic profiling of human B cell reactivities
Leveraging optimized oligonucleotide-tagged antigen assemblies and single-cell sequencing for multiplexed proteogenomic profiling of human B cell reactivities Open
Antigen-specific responses to complex antigens encompass a range of cell states and reactivities to an array of epitopes, reflective of the heterogeneity in immune responses. Single-cell sequencing has created new opportunities when combin…
View article: Effectiveness of CoronaVac primary series with and without booster against hospitalized COVID-19 during the Omicron-predominant epidemic wave in the Philippines: a test-negative case–control study
Effectiveness of CoronaVac primary series with and without booster against hospitalized COVID-19 during the Omicron-predominant epidemic wave in the Philippines: a test-negative case–control study Open
Two doses of CoronaVac offered moderate protection against severe COVID-19. Heterologous boosters significantly improved protection, especially against critical illness and death, supporting ongoing booster campaigns after inactivated vacc…
View article: Protective envelope dimer epitope–like antibodies are elicited against dengue virus in children after infection and vaccination
Protective envelope dimer epitope–like antibodies are elicited against dengue virus in children after infection and vaccination Open
Cross-reactive antibodies to epitopes that span envelope proteins on the virion surface are hypothesized to protect against dengue virus (DENV) infection and disease. Here, we measured antibodies targeting a quaternary epitope called the e…
View article: A descriptive study on feasibility of nasopharyngeal and oropharyngeal swab collection from pediatric research participants in Cebu, Philippines
A descriptive study on feasibility of nasopharyngeal and oropharyngeal swab collection from pediatric research participants in Cebu, Philippines Open
Background Nasopharyngeal (NPS) and oropharyngeal (OPS) swab collection are vital in the diagnosis and surveillance of respiratory viruses. However, the acceptability of these procedures among children remains a challenge. Methods We condu…
View article: Effectiveness of a single-dose mass dengue vaccination in Cebu, Philippines: Final results of a 5-year case-control study
Effectiveness of a single-dose mass dengue vaccination in Cebu, Philippines: Final results of a 5-year case-control study Open
A single dose of CYD-TDV conferred extended protection against more severe presentations of dengue. The study is limited by an absence of baseline dengue serostatus of the participants prior to vaccination but a large majority in this this…
View article: Community responses to a novel house design: A qualitative study of “Star Homes” in Mtwara, southeastern Tanzania
Community responses to a novel house design: A qualitative study of “Star Homes” in Mtwara, southeastern Tanzania Open
Introduction To evaluate the impact of a novel design “Star Home” on the incidence of malaria, respiratory tract infections and diarrheal diseases among children, randomly selected households in Mtwara, Tanzania were offered a free, new St…
View article: Acceptability of improved cook stoves-a scoping review of the literature
Acceptability of improved cook stoves-a scoping review of the literature Open
Improved cooking stoves (ICS) are intended to reduce indoor air pollution and the inefficient use of fuel yet there is often reticence to shift permanently to ICS. Drawing on a scoping review, this article aims to provide a comprehensive o…
View article: Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective
Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective Open
View article: Effectiveness of Coronavac Primary Series with and Without Booster Against Hospitalized COVID-19 During the Omicron-Predominant Epidemic Wave in the Philippines: A Test-Negative Case-Control Study
Effectiveness of Coronavac Primary Series with and Without Booster Against Hospitalized COVID-19 During the Omicron-Predominant Epidemic Wave in the Philippines: A Test-Negative Case-Control Study Open
View article: Effectiveness of a Single-Dose Mass Dengue Vaccination in Cebu, Philippines: Overall Result of a 5-Year Case Control Study
Effectiveness of a Single-Dose Mass Dengue Vaccination in Cebu, Philippines: Overall Result of a 5-Year Case Control Study Open
View article: Impact of the COVID-19 pandemic and a supertyphoon: A quantitative study in Cebu, Philippines
Impact of the COVID-19 pandemic and a supertyphoon: A quantitative study in Cebu, Philippines Open
Pandemics and natural disasters are recognized to cause major disruptions. The main objective of this study was to explore the impacts of COVID-19 and supertyphoon Odette in Cebu, Philippines. A total of 2630 participants were interviewed …
View article: High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines
High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines Open
View article: Using Dried Blood Spots to Quantitatively Detect Anti–SARS-CoV-2 IgG Antibodies by ELISA: A Validation Study
Using Dried Blood Spots to Quantitatively Detect Anti–SARS-CoV-2 IgG Antibodies by ELISA: A Validation Study Open
SARS-CoV-2 serological testing is useful to determine seroprevalence, epidemiological trends, and the extent of transmission. The collection and transport of serum samples can be logistically challenging, especially in remote underserved a…
View article: Care seeking for childhood illnesses in rural Mtwara, south-east Tanzania: a mixed methods study
Care seeking for childhood illnesses in rural Mtwara, south-east Tanzania: a mixed methods study Open
Background Care seeking was assessed in preparation for a study of the health impact of novel design houses in rural Mtwara, Tanzania. Methods A total of 578 residents of 60 villages participated in this mixed-methods study from April to A…
View article: Envelope-dimer epitope-like broadly protective antibodies against dengue in children following natural infection and vaccination
Envelope-dimer epitope-like broadly protective antibodies against dengue in children following natural infection and vaccination Open
Cross-reactive antibodies (Abs) to epitopes that span envelope proteins on the virion surface are hypothesized to protect against dengue. Here, we measured Abs targeting the quaternary envelope dimer epitope (EDE) as well as neutralizing a…
View article: Dengue virus IgG and serotype-specific neutralizing antibody titers measured with standard and mature viruses are associated with protection
Dengue virus IgG and serotype-specific neutralizing antibody titers measured with standard and mature viruses are associated with protection Open
View article: Effect of single-dose, live, attenuated dengue vaccine in children with or without previous dengue on risk of subsequent, virologically confirmed dengue in Cebu, the Philippines: a longitudinal, prospective, population-based cohort study
Effect of single-dose, live, attenuated dengue vaccine in children with or without previous dengue on risk of subsequent, virologically confirmed dengue in Cebu, the Philippines: a longitudinal, prospective, population-based cohort study Open
The Philippine Department of Health, Hanako Foundation, WHO, Swedish International Development Cooperation Agency, International Vaccine Institute, University of North Carolina, and US National Institute of Allergy and Infectious Diseases.
View article: Prospective observational studies to provide confidence in the protection conferred by newer generation, inactivated oral cholera vaccines: a proposal
Prospective observational studies to provide confidence in the protection conferred by newer generation, inactivated oral cholera vaccines: a proposal Open
View article: Understanding reticence to occupy free, novel-design homes: A qualitative study in Mtwara, Southeast Tanzania
Understanding reticence to occupy free, novel-design homes: A qualitative study in Mtwara, Southeast Tanzania Open
Introduction The population of Africa set to reach 2 billion by 2050. There is therefore great demand for housing across the continent. Research on modified novel designs for housing is a priority to ensure that these homes are not sites o…
View article: High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines
High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines Open
View article: Indirect IgG ELISA and serotype-specific neutralizing antibody titers are associated with protection against dengue in children in Cebu, Philippines
Indirect IgG ELISA and serotype-specific neutralizing antibody titers are associated with protection against dengue in children in Cebu, Philippines Open
Standard measures of dengue virus (DENV) antibodies have not been established as protective against dengue. We assess whether an indirect dengue IgG ELISA (PanBio; Brisbane, QLD, Australia) and serotype-specific neutralizing antibody titer…
View article: Detection of envelope-dimer epitope-like broadly protective antibodies in dengue-immune children in the Philippines following vaccination and natural infection
Detection of envelope-dimer epitope-like broadly protective antibodies in dengue-immune children in the Philippines following vaccination and natural infection Open
The dengue vaccine, Dengvaxia, has been described as eliciting antibody-dependent enhancement (ADE) in dengue-naive individuals. There is an urgent need to develop an effective dengue virus (DENV) vaccine that elicits protective, cross-rea…
View article: Dengue algorithms integrated into the IMCI guidelines: An updated assessment in five Southeast-Asian countries
Dengue algorithms integrated into the IMCI guidelines: An updated assessment in five Southeast-Asian countries Open
Background Dengue is not included explicitly in the WHO Integrated Management of Childhood Illness (IMCI) algorithm. However, the assessment, classification and management of dengue has been incorporated into several IMCI country adaptatio…
View article: Correction: Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial
Correction: Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial Open
View article: Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial
Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial Open
View article: Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household randomized controlled trial.
Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household randomized controlled trial. Open
Background:Traditional rural housing in hot, humid regions of sub-Saharan Africa usually consists of single-level, poorly ventilated dwellings. Houses are mostly poorly screened against malaria mosquitoes and limited airflow discourages th…
View article: Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines
Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines Open
Zika virus (ZIKV) is a member of the Flaviviridae family, which includes other clinically notable viruses such as the 4 dengue virus serotypes (DENV-1-4). Distinguishing DENVs from ZIKV using the established serologic assays widely used fo…
View article: Private Demand for Cholera Vaccines in Hue, Vietnam
Private Demand for Cholera Vaccines in Hue, Vietnam Open
Objectives: This study aims to measure the private demand for oral cholera vaccines in Hue, Vietnam, an area of relatively low endemicity of cholera, using the contingent valuation method.MethodsInterviews were conducted with either the he…
View article: Effectiveness of a single-dose mass dengue vaccination in Cebu, Philippines: A case-control study
Effectiveness of a single-dose mass dengue vaccination in Cebu, Philippines: A case-control study Open
A single dose of CYD-TDV given to nine to fourteen-year-old children through a community-based mass vaccination program conferred protection against dengue with warning signs and severe dengue but we were unable to conclude on protection a…
View article: Assessment of Vaccine Herd Protection: Lessons Learned From Cholera and Typhoid Vaccine Trials
Assessment of Vaccine Herd Protection: Lessons Learned From Cholera and Typhoid Vaccine Trials Open
Vaccine herd protection is the extension of the defense conferred by immunization beyond the vaccinated to unvaccinated persons in a population, as well as the enhancement of the protection among the vaccinated, due to vaccination of the s…