Jacqueline E. Hunter
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View article: Transduction characteristics of alternative adeno-associated virus serotypes in the cat brain by intracisternal delivery
Transduction characteristics of alternative adeno-associated virus serotypes in the cat brain by intracisternal delivery Open
Multiple studies have examined the transduction characteristics of different AAV serotypes in the mouse brain, where they can exhibit significantly different patterns of transduction. The pattern of transduction also varies with the route …
View article: Global CNS correction in a large brain model of human alpha-mannosidosis by intravascular gene therapy
Global CNS correction in a large brain model of human alpha-mannosidosis by intravascular gene therapy Open
Intravascular injection of certain adeno-associated virus vector serotypes can cross the blood–brain barrier to deliver a gene into the CNS. However, gene distribution has been much more limited within the brains of large animals compared …