Jacqueline K. Phillips
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View article: Differential cardiovascular risk profiles by sex among adults with CKD: a NHANES-based analysis
Differential cardiovascular risk profiles by sex among adults with CKD: a NHANES-based analysis Open
Introduction Chronic kidney disease (CKD) and cardiovascular disease are closely interconnected, with cardiovascular disease the leading cause of death for those with CKD. This increased risk for those with CKD is partly attributed to shar…
View article: Impaired inhibitory reno-renal reflex responses in chronic kidney disease
Impaired inhibitory reno-renal reflex responses in chronic kidney disease Open
The renal afferent nerves serve as physiologic regulators of efferent renal sympathetic nerve activity (rSNA) as part of the inhibitory reno-renal reflex. Dysregulation of this reflex response may promote sympathoexcitation and subsequent …
View article: Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents
Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents Open
Isoflavones have been identified as potential anti-diabetic agents, but adverse side effects especially at high dosage has continued to plague their clinical uptake. We explore the benefits of individual and co-treatment of diabetic rodent…
View article: Editorial: Insights in integrative physiology: 2022
Editorial: Insights in integrative physiology: 2022 Open
EDITORIAL article Front. Physiol., 23 May 2023Sec. Integrative Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1220684
View article: Editorial: Insights in integrative physiology: 2021
Editorial: Insights in integrative physiology: 2021 Open
EDITORIAL article Front. Physiol., 27 March 2023Sec. Integrative Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1186581
View article: Patient Selection for Renal Denervation in Hypertensive Patients: What Makes a Good Candidate?
Patient Selection for Renal Denervation in Hypertensive Patients: What Makes a Good Candidate? Open
Renal denervation (RDN) as a therapeutic intervention in patients with hypertension has been intensively studied for over a decade, yet a critical question remains unanswered: what kind of patients are the ideal target population for RDN t…
View article: Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease
Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease Open
Autosomal recessive polycystic kidney disease (ARPKD) is an early onset genetic disorder characterized by numerous renal cysts resulting in end stage renal disease. Our study aimed to determine if metabolic reprogramming and tryptophan (Tr…
View article: Upregulated Angiotensin Ia Receptors in the Hypothalamic Paraventricular Nucleus Sensitize Neuroendocrine Vasopressin Release and Blood Pressure in a Rodent Model of Polycystic Kidney Disease
Upregulated Angiotensin Ia Receptors in the Hypothalamic Paraventricular Nucleus Sensitize Neuroendocrine Vasopressin Release and Blood Pressure in a Rodent Model of Polycystic Kidney Disease Open
Introduction: Angiotensin (Ang) II signalling in the hypothalamic paraventricular nucleus (PVN) via Ang type-1a receptors (AT1R) regulates vasopressin release and sympathetic nerve activity – two effectors of blood pressure regulation. We …
View article: Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease
Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease Open
The exponential rise in our understanding of the aetiology and pathophysiology of genetic cystic kidney diseases can be attributed to the identification of cystogenic genes over the last three decades. The foundation of this was laid by po…
View article: Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis
Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis Open
Chronic kidney disease (CKD) is a significant health challenge associated with high cardiovascular mortality risk. Historically, cardiovascular mortality risk has been found to higher in men than women in the general population. However, r…
View article: Augmented Respiratory–Sympathetic Coupling and Hemodynamic Response to Acute Mild Hypoxia in Female Rodents With Chronic Kidney Disease
Augmented Respiratory–Sympathetic Coupling and Hemodynamic Response to Acute Mild Hypoxia in Female Rodents With Chronic Kidney Disease Open
Carotid body feedback and hypoxia may serve to enhance respiratory–sympathetic nerve coupling (respSNA) and act as a driver of increased blood pressure. Using the Lewis polycystic kidney (LPK) rat model of chronic kidney disease, we examin…
View article: P.62 Assessment of Isoflavone and Ethanolic Extract of Inonotus Obliquus on Experimentally Induced Diabetes
P.62 Assessment of Isoflavone and Ethanolic Extract of Inonotus Obliquus on Experimentally Induced Diabetes Open
Purpose Studies support beneficial effects of isoflavones, but antidiabetic effects of these agents remains unconfirmed [1,2]. This pilot study investigates isoflavones and Inonotus obliquus (chaga) extract effects on diabetes. Methods Dia…
View article: Amlodipine Improves Vessel Function and Remodeling in the Lewis Polycystic Kidney Rat Mesenteric Artery
Amlodipine Improves Vessel Function and Remodeling in the Lewis Polycystic Kidney Rat Mesenteric Artery Open
BACKGROUND Hypertension is a common comorbidity associated with chronic kidney disease (CKD). Treatment in these patients often involves L-type Ca2+ channel (LTCC) blockers. The effect of chronic LTCC-blockade treatment on resistance vascu…
View article: Neurons in the Intermediate Reticular Nucleus Coordinate Postinspiratory Activity, Swallowing, and Respiratory-Sympathetic Coupling in the Rat
Neurons in the Intermediate Reticular Nucleus Coordinate Postinspiratory Activity, Swallowing, and Respiratory-Sympathetic Coupling in the Rat Open
Breathing results from sequential recruitment of muscles in the expiratory, inspiratory, and postinspiratory (post-I) phases of the respiratory cycle. Here we investigate whether neurons in the medullary intermediate reticular nucleus (IRt…
View article: SAT-331 RENAL DENERVATION DOES NOT REDUCE BLOOD PRESSURE IN A RODENT MODEL OF POLYCYSTIC KIDNEY DISEASE
SAT-331 RENAL DENERVATION DOES NOT REDUCE BLOOD PRESSURE IN A RODENT MODEL OF POLYCYSTIC KIDNEY DISEASE Open
Hypertension is a common, early feature of polycystic kidney disease (PKD) that contributes to the development of cardiovascular disease, a leading cause of mortality in these patients. Effective control of hypertension is therefore essent…
View article: Respiratory sympathetic modulation is augmented in chronic kidney disease
Respiratory sympathetic modulation is augmented in chronic kidney disease Open
Respiratory modulation of sympathetic nerve activity (respSNA) was studied in a hypertensive rodent model of chronic kidney disease (CKD) using Lewis Polycystic Kidney (LPK) rats and Lewis controls. In adult animals under in vivo anaesthet…
View article: Process Design: Maleic Anhydride Unit
Process Design: Maleic Anhydride Unit Open
Gamecock Chemical Company has proposed the construction of a maleic anhydride plant at its Houston refinery. The plant is to produce 40,000 metric tons per year of maleic anhydride from a mixture of excess butanes. This design team has bee…
View article: Cortistatin—can it or can it not prevent vascular calcification by modulation of Wnt signalling?
Cortistatin—can it or can it not prevent vascular calcification by modulation of Wnt signalling? Open
In this issue of Acta Physiologica, a paper by Liu et al1 examines the mechanisms by which the neuropeptide cortistatin ameliorates calcification in animal and cell-based models of vascular calcification. Previous work by the authors estab…
View article: AT1 Receptor Antagonism Improves Structural, Functional, and Biomechanical Properties in Resistance Arteries in a Rodent Chronic Kidney Disease Model
AT1 Receptor Antagonism Improves Structural, Functional, and Biomechanical Properties in Resistance Arteries in a Rodent Chronic Kidney Disease Model Open
BACKGROUND The renin–angiotensin system, in particular Angiotensin II (AngII), plays a significant role in the pathogenesis of hypertension in chronic kidney disease (CKD). Effects of chronic AT1 receptor antagonism were investigated in a …
View article: Osmoregulation in Polycystic Kidney Disease: Relationship with Cystogenesis and Hypertension
Osmoregulation in Polycystic Kidney Disease: Relationship with Cystogenesis and Hypertension Open
Polycystic kidney disease (PKD) is a group of monogenetic conditions characterised by the progressive accumulation of multiple renal cysts and hypertension. One of the earliest features of PKD is a reduction in urinary concentrating capaci…
View article: Effects of TORC1 Inhibition during the Early and Established Phases of Polycystic Kidney Disease
Effects of TORC1 Inhibition during the Early and Established Phases of Polycystic Kidney Disease Open
The disease-modifying effects of target of rapamycin complex 1 (TORC1) inhibitors during different stages of polycystic kidney disease (PKD) are not well defined. In this study, male Lewis Polycystic Kidney Disease (LPK) rats (a genetic or…
View article: Supplementary Material for: Long-Term Angiotensin II Receptor Blockade Limits Hypertension, Aortic Dysfunction, and Structural Remodeling in a Rat Model of Chronic Kidney Disease
Supplementary Material for: Long-Term Angiotensin II Receptor Blockade Limits Hypertension, Aortic Dysfunction, and Structural Remodeling in a Rat Model of Chronic Kidney Disease Open
Background/Aims: Chronic kidney disease (CKD) is associated with large artery remodeling, endothelial dysfunction and calcification, with angiotensin II (Ang II) a known driver of these pathologies. We investigated long-term Ang II type 1 …
View article: Supplementary Material for: Long-Term Angiotensin II Receptor Blockade Limits Hypertension, Aortic Dysfunction, and Structural Remodeling in a Rat Model of Chronic Kidney Disease
Supplementary Material for: Long-Term Angiotensin II Receptor Blockade Limits Hypertension, Aortic Dysfunction, and Structural Remodeling in a Rat Model of Chronic Kidney Disease Open
Background/Aims: Chronic kidney disease (CKD) is associated with large artery remodeling, endothelial dysfunction and calcification, with angiotensin II (Ang II) a known driver of these pathologies. We investigated long-term Ang II type 1 …