Jacques Gardon
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View article: Revisiting the Loa loa microfilaremia thresholds above which serious adverse events may occur with ivermectin treatment
Revisiting the Loa loa microfilaremia thresholds above which serious adverse events may occur with ivermectin treatment Open
Background Loiasis was long deemed to be a benign condition, but individuals with high Loa loa microfilarial densities (MFD) are at risk of serious adverse events (SAEs) including encephalopathy following ivermectin (IVM) administration. T…
View article: Genotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes—A cross sectional study
Genotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes—A cross sectional study Open
Elevated concentrations of arsenic, lithium and boron in drinking water have already been reported in Bolivia. Arsenic is known to cause genotoxicity but that caused by lithium and boron is less well known. The aim of the present cross‐sec…
View article: Arsenic exposure and cancer-related biomarkers in indigenous populations in Bolivia – modification by arsenic metabolism efficiency
Arsenic exposure and cancer-related biomarkers in indigenous populations in Bolivia – modification by arsenic metabolism efficiency Open
Inorganic arsenic is a known carcinogen. Telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) in peripheral blood may serve as biomarkers for genotoxicity and cancer risk. Our aim is to assess if arsenic exposure influences TL …
View article: Lead-based paint detection using perovskite fluorescence and X-ray fluorescence
Lead-based paint detection using perovskite fluorescence and X-ray fluorescence Open
Ingestion of flakes of Pb-based paint by infants remains a health hazard with life-long consequences throughout the world. Pb-based paint was banned for residential use in the US and Western Europe decades ago but is still sold in many cou…
View article: Genotoxicity in humans exposed to arsenic and lithium in drinking water in the Bolivian Andes
Genotoxicity in humans exposed to arsenic and lithium in drinking water in the Bolivian Andes Open
Elevated concentrations of arsenic, lithium and boron in drinking water have already been reported in the Bolivian Andes. Arsenic causes genotoxicity but that caused by lithium and boron is less well known. The aim of the present study was…
View article: Genetic factors for differentiated thyroid cancer in French Polynesia: new candidate loci
Genetic factors for differentiated thyroid cancer in French Polynesia: new candidate loci Open
Background Populations of French Polynesia (FP), where France performed atmospheric tests between 1966 and 1974, experience a high incidence of differentiated thyroid cancer (DTC). However, up to now, no sufficiently large study of DTC gen…
View article: Assessment of Differentiated Thyroid Carcinomas in French Polynesia After Atmospheric Nuclear Tests Performed by France
Assessment of Differentiated Thyroid Carcinomas in French Polynesia After Atmospheric Nuclear Tests Performed by France Open
Importance Due to the amount of iodine 131 released in nuclear tests and its active uptake by the thyroid, differentiated thyroid carcinoma (DTC) is the most serious health risk for the population living near sites of nuclear tests. Whethe…
View article: Evaluating post-treatment Loa loa microfilarial densities to classify serious adverse events caused by ivermectin: a retrospective analysis
Evaluating post-treatment Loa loa microfilarial densities to classify serious adverse events caused by ivermectin: a retrospective analysis Open
International audience
View article: Arsenic Exposure and Cancer-Related Proteins in Urine of Indigenous Bolivian Women
Arsenic Exposure and Cancer-Related Proteins in Urine of Indigenous Bolivian Women Open
Indigenous people living in the Bolivian Andes are exposed through their drinking water to inorganic arsenic, a potent carcinogen. However, the health consequences of arsenic exposure in this region are unknown. The aim of this study was t…
View article: Thyroid Doses to French Polynesians Resulting from Atmospheric Nuclear Weapons Tests: Estimates Based on Radiation Measurements and Population Lifestyle Data
Thyroid Doses to French Polynesians Resulting from Atmospheric Nuclear Weapons Tests: Estimates Based on Radiation Measurements and Population Lifestyle Data Open
Thyroid doses were estimated for the subjects of a population-based case-control study of thyroid cancer in a population exposed to fallout after atmospheric nuclear weapons tests conducted in French Polynesia between 1966 and 1974. Thyroi…
View article: Subjects living in an onchocerciasis focus and treated 3-monthly with ivermectin develop fewer new onchocercal nodules than subjects treated annually
Subjects living in an onchocerciasis focus and treated 3-monthly with ivermectin develop fewer new onchocercal nodules than subjects treated annually Open
Background: Little information is available on the effect of ivermectin on the third and fourth stage larvae of Onchocerca volvulus. To assess a possible prophylactic effect of ivermectin on this parasite, we compared the effects of differ…
View article: Subjects living in an onchocerciasis focus and treated 3-monthly with ivermectin develop fewer new onchocercal nodules than subjects treated annually
Subjects living in an onchocerciasis focus and treated 3-monthly with ivermectin develop fewer new onchocercal nodules than subjects treated annually Open
Background Little information is available on the effect of ivermectin on the third and fourth stage larvae of Onchocerca volvulus . To assess a possible prophylactic effect of ivermectin on this parasite, we compared the effects of differ…
View article: Behavior and Food Consumption Pattern of the French Polynesian Population in the 1960s –1970s
Behavior and Food Consumption Pattern of the French Polynesian Population in the 1960s –1970s Open
This article presents the first detailed information on several key aspects of daily life on French Polynesian archipelagoes during the 1960s-1970s impacting radiation exposure. Important behavior and food consumptions data obtained in thi…
View article: Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk
Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk Open
Background: In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer. Objective:…
View article: Effect of a Single Standard Dose (150–200 μg/kg) of Ivermectin on<i>Loa loa</i>Microfilaremia: Systematic Review and Meta-analysis
Effect of a Single Standard Dose (150–200 μg/kg) of Ivermectin on<i>Loa loa</i>Microfilaremia: Systematic Review and Meta-analysis Open
A single dose of IVM is very effective at substantially reducing L. loa MFD for at least a year, irrespective of the initial level of parasitemia. Individuals treated with IVM are probably not any more at risk of severe adverse events when…
View article: Macrofilaricidal Efficacy of Repeated Doses of Ivermectin for the Treatment of River Blindness
Macrofilaricidal Efficacy of Repeated Doses of Ivermectin for the Treatment of River Blindness Open
Our quantification of macrofilaricidal and sterilizing effects of ivermectin should be incorporated into transmission models to inform onchocerciasis elimination efforts in Africa and residual foci in Latin America. It also provides a fram…
View article: Herbal Medicine Practices of Patients With Liver Cancer in Peru: A Comprehensive Study Toward Integrative Cancer Management
Herbal Medicine Practices of Patients With Liver Cancer in Peru: A Comprehensive Study Toward Integrative Cancer Management Open
Rationale: The highest burden of liver cancer occurs in developing countries, where the use of herbal medicine (HM) is still widespread. Despite this trend, few studies have been conducted to report HM practices of patients with a hepatic …