Jacques Le Pendu
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View article: COVID-19 and blood group-related antigens: can natural anti-carbohydrate antibodies provide innate protection from symptomatic SARS-CoV-2 infection?
COVID-19 and blood group-related antigens: can natural anti-carbohydrate antibodies provide innate protection from symptomatic SARS-CoV-2 infection? Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets respiratory mucosa, causing coronavirus disease 2019 (COVID-19). Susceptibility and severity of COVID-19 may be influenced by predisposing factors in…
View article: Species-Specific N-Glycomes and Methylation Patterns of Oysters Crassostrea gigas and Ostrea edulis and Their Possible Consequences for the Norovirus–HBGA Interaction
Species-Specific N-Glycomes and Methylation Patterns of Oysters Crassostrea gigas and Ostrea edulis and Their Possible Consequences for the Norovirus–HBGA Interaction Open
Noroviruses, the major cause of acute viral gastroenteritis, are known to bind to histo-blood group antigens (HBGAs), including ABH groups and Lewis-type epitopes, which decorate the surface of erythrocytes and epithelial cells of their ho…
View article: Extent of the protection afforded by histo-blood group polymorphism against rotavirus gastroenteritis in metropolitan France and French Guiana
Extent of the protection afforded by histo-blood group polymorphism against rotavirus gastroenteritis in metropolitan France and French Guiana Open
Human rotaviruses attach to histo-blood group antigens glycans and null alleles of the ABO , FUT2 and FUT3 genes seem to confer diminished risk of gastroenteritis. Yet, the true extent of this protection remains poorly quantified. Here, we…
View article: Microbiota-induced regulatory T cells associate with FUT2-dependent susceptibility to rotavirus gastroenteritis
Microbiota-induced regulatory T cells associate with FUT2-dependent susceptibility to rotavirus gastroenteritis Open
The FUT2 α1,2fucosyltransferase contributes to the synthesis of fucosylated glycans used as attachment factors by several pathogens, including noroviruses and rotaviruses, that can induce life-threatening gastroenteritis in young children.…
View article: Epidemiological Impact of GII.17 Human Noroviruses Associated With Attachment to Enterocytes
Epidemiological Impact of GII.17 Human Noroviruses Associated With Attachment to Enterocytes Open
For the last 30 years, molecular surveys have shown that human norovirus (HuNoV), predominantly the GII.4 genotype, is one of the main causative agents of gastroenteritis. However, epidemiological surveys have revealed the worldwide emerge…
View article: ABO Blood Group Incompatibility Protects Against SARS-CoV-2 Transmission
ABO Blood Group Incompatibility Protects Against SARS-CoV-2 Transmission Open
ABO blood groups appear to be associated with the risk of SARS-CoV-2 infection, but the underlying mechanisms and their real importance remain unclear. Two hypotheses have been proposed: ABO compatibility-dependence (neutralization by anti…
View article: Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19
Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19 Open
Human serum contains large amounts of anti-carbohydrate antibodies, some of which may recognize epitopes on viral glycans. Here, we tested the hypothesis that such antibodies may confer protection against COVID-19 so that patients would be…
View article: ABO Blood Types and COVID-19: Spurious, Anecdotal, or Truly Important Relationships? A Reasoned Review of Available Data
ABO Blood Types and COVID-19: Spurious, Anecdotal, or Truly Important Relationships? A Reasoned Review of Available Data Open
Since the emergence of COVID-19, many publications have reported associations with ABO blood types. Despite between-study discrepancies, an overall consensus has emerged whereby blood group O appears associated with a lower risk of COVID-1…
View article: Covid-19 and blood groups: ABO antibody levels may also matter
Covid-19 and blood groups: ABO antibody levels may also matter Open
In this study, we showed that ABO antibody levels are significantly lower in Covid-19 patients compared to controls. These findings could indicate that patients with low levels of ABO antibodies are at higher risk of being infected.
View article: FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil
FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil Open
Host susceptibility according to human histo-blood group antigens (HBGAs) is widely known for norovirus infection, but is less described for rotavirus. Due to the variable HBGA polymorphism among populations, we aimed to evaluate the assoc…
View article: Human Natural Antibodies Recognizing Glycan Galβ1-3GlcNAc (LeC)
Human Natural Antibodies Recognizing Glycan Galβ1-3GlcNAc (LeC) Open
The level of human natural antibodies of immunoglobulin M isotype against LeC in patients with breast cancer is lower than in healthy women. The epitope specificity of these antibodies has been characterized using a printed glycan array an…
View article: <scp> <i>Macrobrachium rosenbergii</i> </scp> nodavirus virus‐like particles attach to fucosylated glycans in the gills of the giant freshwater prawn
<span> <i>Macrobrachium rosenbergii</i> </span> nodavirus virus‐like particles attach to fucosylated glycans in the gills of the giant freshwater prawn Open
The Macrobrachium rosenbergii nodavirus (MrNV), the causative agent of white-tail disease (WTD) in many species of shrimp and prawn, has been shown to infect hemocytes and tissues such as the gills and muscles. However, little is known abo…
View article: Harnessing the natural anti-glycan immune response to limit the transmission of enveloped viruses such as SARS-CoV-2
Harnessing the natural anti-glycan immune response to limit the transmission of enveloped viruses such as SARS-CoV-2 Open
International audience
View article: Genetic diversity and evolution of Hare Calicivirus (HaCV), a recently identified lagovirus from Lepus europaeus
Genetic diversity and evolution of Hare Calicivirus (HaCV), a recently identified lagovirus from Lepus europaeus Open
View article: Host-Range Shift Between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains
Host-Range Shift Between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains Open
In Tunisia, we observed that rotavirus P[8]-3 and P[4] strains in young children with gastroenteritis associate with secretor histo-blood group phenotype. In contrast, the emerging P[8]-4 strain, representing 10% of cases, was exclusively …
View article: Fondness for sugars of enteric viruses confronts them with human glycans genetic diversity
Fondness for sugars of enteric viruses confronts them with human glycans genetic diversity Open
View article: The Coxsackievirus and Adenovirus Receptor, a Required Host Factor for Recovirus Infection, Is a Putative Enteric Calicivirus Receptor
The Coxsackievirus and Adenovirus Receptor, a Required Host Factor for Recovirus Infection, Is a Putative Enteric Calicivirus Receptor Open
Because of the lack of a simple and robust human norovirus (HuNoV) cell culture system surrogate, caliciviruses still represent valuable research tools for norovirus research. Due to their remarkable biological similarities to HuNoVs, incl…
View article: Author Correction: The wide utility of rabbits as models of human diseases
Author Correction: The wide utility of rabbits as models of human diseases Open
View article: Alterations of the iNKT cell compartment in brain-injured patients
Alterations of the iNKT cell compartment in brain-injured patients Open
View article: Dual Recognition of Sialic Acid and αGal Epitopes by the VP8* Domains of the Bovine Rotavirus G6P[5] WC3 and of Its Mono-reassortant G4P[5] RotaTeq Vaccine Strains
Dual Recognition of Sialic Acid and αGal Epitopes by the VP8* Domains of the Bovine Rotavirus G6P[5] WC3 and of Its Mono-reassortant G4P[5] RotaTeq Vaccine Strains Open
Group A rotaviruses initiate infection through the binding of the VP8* domain of the VP4 protein to sialic acids (SAs) or histo-blood group antigens (HBGAs). Although the bovine G6P[5] WC3 strain is an important animal pathogen and is used…
View article: 3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation
3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation Open
View article: Histo-blood group antigen-binding specificities of human rotaviruses are associated with gastroenteritis but not with in vitro infection
Histo-blood group antigen-binding specificities of human rotaviruses are associated with gastroenteritis but not with in vitro infection Open
Human strains of rotavirus A (RVAs) recognize fucosylated glycans belonging to histo-blood group antigens (HBGAs) through their spike protein VP8*. Lack of these ligands due to genetic polymorphisms is associated with resistance to gastroe…
View article: The wide utility of rabbits as models of human diseases
The wide utility of rabbits as models of human diseases Open
View article: Bovine Nebovirus Interacts with a Wide Spectrum of Histo-Blood Group Antigens
Bovine Nebovirus Interacts with a Wide Spectrum of Histo-Blood Group Antigens Open
Some viruses within the Caliciviridae family initiate their replication cycle by attachment to cell surface carbohydrate moieties, histo-blood group antigens (HBGAs), and/or terminal sialic acids (SAs). Although bovine nebovirus (BNeV), on…
View article: Host-Specific Glycans Are Correlated with Susceptibility to Infection by Lagoviruses, but Not with Their Virulence
Host-Specific Glycans Are Correlated with Susceptibility to Infection by Lagoviruses, but Not with Their Virulence Open
Rabbit hemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV) are two lagoviruses from the family Caliciviridae that cause fatal diseases in two leporid genera, Oryctolagus and Lepus , respectively. In the last few…
View article: Proposal for a unified classification system and nomenclature of lagoviruses
Proposal for a unified classification system and nomenclature of lagoviruses Open
FIGURE 7. Images demonstrating the range of metachrosis that was observed in the holotype of Bolitoglossa aurae sp. nov. Photographs taken by BK.
View article: Relationships between host-species specificities and glycan specificities of 1 pathogenic and non-pathogenic lagoviruses
Relationships between host-species specificities and glycan specificities of 1 pathogenic and non-pathogenic lagoviruses Open
International audience
View article: Sustained fecal-oral human-to-human transmission following a zoonotic event
Sustained fecal-oral human-to-human transmission following a zoonotic event Open
View article: Anti-viral Effect of Bifidobacterium adolescentis against Noroviruses
Anti-viral Effect of Bifidobacterium adolescentis against Noroviruses Open
This study aims to investigate the effect of Bifidobacterium adolescentis against noroviruses (NoVs). Murine norovirus-1 (MNV-1) used as a surrogate was detected by plaque assay and RT-qPCR. Human NoV virus like particles (VLPs) were detec…
View article: Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through<i>CLEC17A</i>(Prolectin)
Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through<i>CLEC17A</i>(Prolectin) Open
Terminal fucosylated motifs of glycoproteins and glycolipid chains are often altered in cancer cells. We investigated the link between fucosylation changes and critical steps in cancer progression: epithelial-to-mesenchymal transition (EMT…