Jacques Touchon
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View article: Brain photobiomodulation: a potential treatment in Alzheimer’s and Parkinson’s diseases
Brain photobiomodulation: a potential treatment in Alzheimer’s and Parkinson’s diseases Open
Alzheimer's Disease (AD) and Parkinson's Disease (PD) are common neurodegenerative diseases, characterized by the progressive loss of synapses and neurons, leading to cognitive and motor decline. Their pathophysiology includes cerebral les…
View article: Dorsoventral photobiomodulation therapy safely reduces inflammation and sensorimotor deficits in a mouse model of multiple sclerosis
Dorsoventral photobiomodulation therapy safely reduces inflammation and sensorimotor deficits in a mouse model of multiple sclerosis Open
View article: Photobiomodulation Therapy: A Novel Therapeutic Approach to Alzheimer's Disease Made Possible by the Evidence of a Brain–Gut Interconnection
Photobiomodulation Therapy: A Novel Therapeutic Approach to Alzheimer's Disease Made Possible by the Evidence of a Brain–Gut Interconnection Open
The evidence of brain–gut interconnections in Alzheimer’s disease (AD) opens novel avenues for the treatment of a pathology for which no definitive treatment exists. Gut microbiota and bacterial translocation may produce peripheral inflamm…
View article: Brain–gut photobiomodulation restores cognitive alterations in chronically stressed mice through the regulation of Sirt1 and neuroinflammation
Brain–gut photobiomodulation restores cognitive alterations in chronically stressed mice through the regulation of Sirt1 and neuroinflammation Open
Our results suggest that non-invasive photobiomodulation of both the brain and the gut microbiome could be beneficial in the context of stress-induced MDD.
View article: Translation from Preclinical Research to Clinical Trials: Brain–Gut Photobiomodulation Therapy for Alzheimer's Disease
Translation from Preclinical Research to Clinical Trials: Brain–Gut Photobiomodulation Therapy for Alzheimer's Disease Open
Recently, novel non-pharmacological interventions, such as photobiomodulation (PBM) therapy, have shown promise for the treatment of Alzheimer’s disease (AD). This article outlines the translation from the preclinical to clinical stages of…
View article: Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial
Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial Open
Toulouse Gérontopôle, French Ministry of Health and Pierre Fabre Research Institute.
View article: Challenges in developing Geroscience trials
Challenges in developing Geroscience trials Open
View article: Investigating three ways of measuring the intrinsic capacity domain of vitality: nutritional status, handgrip strength and ageing biomarkers
Investigating three ways of measuring the intrinsic capacity domain of vitality: nutritional status, handgrip strength and ageing biomarkers Open
Background Vitality is conceptually considered as the underlying capacity influencing other intrinsic capacity (IC) domains and being related to nutrition, physiological reserve and biological ageing. However, there is no consensus on its …
View article: Music Care, a personalized smartphone app for the relief of pain and anxiety: A Systematic Review of Randomized Controlled Trials (Preprint)
Music Care, a personalized smartphone app for the relief of pain and anxiety: A Systematic Review of Randomized Controlled Trials (Preprint) Open
BACKGROUND Digital technologies and emerging innovations are increasingly being used to strengthen national health systems. Based on scientific recommendations, Music Care©, a web app-based personalized music intervention has been develop…
View article: Cumulative effects of subsequent concussions on the neural patterns of young rugby athletes: data from event-related potentials
Cumulative effects of subsequent concussions on the neural patterns of young rugby athletes: data from event-related potentials Open
Our study aimed at detecting a potential cumulative effect of subsequent concussions on the neural activation patterns of young rugby athletes with or without concussion history. Event-related brain potential (ERP) data from 24 rugby playe…
View article: Association between urate-lowering therapies and cognitive decline in community-dwelling older adults
Association between urate-lowering therapies and cognitive decline in community-dwelling older adults Open
View article: Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults Open
View article: Plasma amyloid beta predicts conversion to dementia in subjects with mild cognitive impairment: The BALTAZAR study
Plasma amyloid beta predicts conversion to dementia in subjects with mild cognitive impairment: The BALTAZAR study Open
Introduction Blood‐based biomarkers are the next challenge for Alzheimer's disease (AD) diagnosis and prognosis. Methods Mild cognitive impairment (MCI) participants (N = 485) of the BALTAZAR study, a large‐scale longitudinal multicenter c…
View article: Prospective Associations of Plasma Growth Differentiation Factor 15 With Physical Performance and Cognitive Functions in Older Adults
Prospective Associations of Plasma Growth Differentiation Factor 15 With Physical Performance and Cognitive Functions in Older Adults Open
Background Growth differentiation factor 15 (GDF15) has been associated with several age-related disorders, but its associations with functional abilities in community-dwelling older adults are not well studied. Methods The study was a sec…
View article: Plasma MCP-1 and changes on cognitive function in community-dwelling older adults
Plasma MCP-1 and changes on cognitive function in community-dwelling older adults Open
Background Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in com…
View article: Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study
Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study Open
Background It has been documented that β‐amyloid (Aβ) deposition, tau pathology and neuronal degeneration precedes clinical symptoms in autosomal dominant Alzheimer's disease (AD). Since the divergence on pathogenesis between sporadic and …
View article: Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults
Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults Open
View article: Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials
Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials Open
Background Evidence on preventing Alzheimer’s disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We completed a systematic review and meta-analysis of current evidence with p…
View article: Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study
Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study Open
Introduction: Amyloid beta (Aβ) deposition was identified to precede tau pathology and neurodegeneration in familial Alzheimer's disease (AD). But the divergence between sporadic and familial AD limits the extension of these findings to sp…
View article: Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults
Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults Open
Background and objectives Low eGFR is known to be associated with frailty, but the association between the longitudinal decline of eGFR and incident frailty in older persons remains to be determined. The objective of this study was to inve…
View article: P4‐199: PERSISTENT EFFECTS OF CONCUSSION ON ERPS IN FRENCH RUGBY PLAYERS
P4‐199: PERSISTENT EFFECTS OF CONCUSSION ON ERPS IN FRENCH RUGBY PLAYERS Open
Mild traumatic brain injurie (mTBI) resulting from sport concussion is a major public health affecting around 3 million individuals annualy and more than 800000 children are treated for TBI every year. Even if the injury is generally trans…
View article: Neuroprotection Afforded by a Preventive CogniXtra Treatment Against Amyloid Beta Aβ25-35 Peptide-induced Toxicity in Mice
Neuroprotection Afforded by a Preventive CogniXtra Treatment Against Amyloid Beta Aβ25-35 Peptide-induced Toxicity in Mice Open
Objective: A number of encouraging research studies have shown the importance of nutritional approach in order to protect the brainhealth. Here we present the efficacy of a daily administration of a unique complex combination of omega 3 fa…
View article: Evidence-Based Prevention of Alzheimer's Disease: Systematic Review and Meta-Analysis of 243 Observational Prospective Studies and 153 Randomized Controlled Trials
Evidence-Based Prevention of Alzheimer's Disease: Systematic Review and Meta-Analysis of 243 Observational Prospective Studies and 153 Randomized Controlled Trials Open
View article: P1‐061: DOUBLE‐BLIND ARGUMENT FOR A SYNERGISTIC THERAPEUTIC EFFECT OF A FIXED LOW‐DOSE COMBINATION OF ACAMPROSATE AND BACLOFEN IN ALZHEIMER'S DISEASE
P1‐061: DOUBLE‐BLIND ARGUMENT FOR A SYNERGISTIC THERAPEUTIC EFFECT OF A FIXED LOW‐DOSE COMBINATION OF ACAMPROSATE AND BACLOFEN IN ALZHEIMER'S DISEASE Open
PXT-864, a fixed low-dose combination of repositioned acamprosate and baclofen, has shown multiple reversions of pathological alteration in cellular and animal models of Alzheimer's disease (AD) (Chumakov 2014), in addition of good safety …
View article: Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers
Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers Open
Introduction Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results. The objective of the study was to assess plasma levels of Aβ 42 and Aβ 40 in amnestic mild cognitive impairment (MC…
View article: Neuroprotective effect of a new photobiomodulation technique against Aβ <sub>25–35</sub> peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested
Neuroprotective effect of a new photobiomodulation technique against Aβ <sub>25–35</sub> peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested Open
Introduction Photobiomodulation was assessed as a novel treatment of Alzheimer's disease (AD) by the use of a new device RGn500 combining photonic and magnetic emissions in a mouse model of AD. Methods Following the injection of amyloid β …
View article: Collaborative efforts to prevent Alzheimer's disease
Collaborative efforts to prevent Alzheimer's disease Open
View article: RETRACTED ARTICLE: Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study
RETRACTED ARTICLE: Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study Open
View article: Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer’s Disease
Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer’s Disease Open
ClinicalTrials.gov identifier: NCT00403520.
View article: P4‐125: Cognitive Event‐Related Potentials Used As Biomarkers in Pleodial‐I Study: First Evidence of a Neurophysiological Effect of PXT864 in Mild Alzheimer’s Disease Patients
P4‐125: Cognitive Event‐Related Potentials Used As Biomarkers in Pleodial‐I Study: First Evidence of a Neurophysiological Effect of PXT864 in Mild Alzheimer’s Disease Patients Open
Cognitive event related potential (ERP) is a usefull biomarker for the diagnosis of Alzheimer's Disease (AD), even from the preclinical stage. We report here the use of ERP in a phase IIa clinical study to explore in mild AD patients the s…