Joe L. Hsu
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View article: Pirfenidone for the treatment of bronchiolitis obliterans syndrome related to chronic graft-versus-host disease
Pirfenidone for the treatment of bronchiolitis obliterans syndrome related to chronic graft-versus-host disease Open
Bronchiolitis obliterans syndrome (BOS) is a severe form of chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic cell transplant (HCT), with a 5-year survival rate of 40%. Currently, there is no curative therapy for…
View article: Macrophage ferroptosis inhibits <i>Aspergillus</i> conidial killing in lung transplantation
Macrophage ferroptosis inhibits <i>Aspergillus</i> conidial killing in lung transplantation Open
Immune suppression heightens the risk for fungal infections, but the mechanisms that result in clinical disease are poorly understood. Here we demonstrate that macrophage ferroptosis, an iron-dependent form of regulated cell death, inhibit…
View article: CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant
CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant Open
Bronchiolitis obliterans syndrome (BOS) after hematopoietic cell transplantation (HCT) is associated with substantial morbidity and mortality. Quantitative computed tomography (qCT) can help diagnose advanced BOS meeting National Institute…
View article: Allergic Bronchopulmonary Aspergillosis (ABPA) in the Era of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators
Allergic Bronchopulmonary Aspergillosis (ABPA) in the Era of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators Open
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disease caused by Aspergillus fumigatus (Af), prevalent in persons with cystic fibrosis (CF) or asthma. In ABPA, Af proteases drive a T-helper cell-2 (Th2)-mediated aller…
View article: The Expanding Mycovirome of Aspergilli
The Expanding Mycovirome of Aspergilli Open
Mycoviruses are viruses that infect fungi and are widespread across all major fungal taxa, exhibiting great biological diversity. Since their discovery in the 1960s, researchers have observed a myriad of fungal phenotypes altered due to my…
View article: How I diagnose and treat organizing pneumonia in hematopoietic cell transplant recipients
How I diagnose and treat organizing pneumonia in hematopoietic cell transplant recipients Open
Organizing pneumonia (OP) is a known noninfectious pulmonary complication following allogeneic hematopoietic cell transplant (HCT) and represents a significant risk factor for nonrelapse mortality in HCT recipients. Unlike bronchiolitis ob…
View article: NCCN Guidelines® Insights: Hematopoietic Cell Transplantation, Version 3.2022
NCCN Guidelines® Insights: Hematopoietic Cell Transplantation, Version 3.2022 Open
The NCCN Guidelines for Hematopoietic Cell Transplantation (HCT) provide an evidence- and consensus-based approach for the use of autologous and allogeneic HCT in the management of malignant diseases in adult patients. HCT is a potentially…
View article: Macrophage Lysosomal Alkalinization Drives Invasive Aspergillosis in a Mouse Cystic Fibrosis Model of Airway Transplantation
Macrophage Lysosomal Alkalinization Drives Invasive Aspergillosis in a Mouse Cystic Fibrosis Model of Airway Transplantation Open
Cystic fibrosis (CF) lung transplant recipients (LTRs) exhibit a disproportionately high rate of life-threatening invasive aspergillosis (IA). Loss of the cystic fibrosis transmembrane conductance regulator (CFTR-/-) in macrophages (mφs) h…
View article: Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease
Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease Open
The field of infectious diseases currently takes a reactive approach and treats infections as they present in patients. Although certain populations are known to be at greater risk of developing infection (eg, immunocompromised), we lack a…
View article: Hematopoietic Cell Transplantation, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology
Hematopoietic Cell Transplantation, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology Open
Hematopoietic cell transplantation (HCT) involves the infusion of hematopoietic progenitor cells into patients with hematologic disorders with the goal of re-establishing normal hematopoietic and immune function. HCT is classified as autol…
View article: Supplementary Material for: The Specific Organism: Not Bacterial Gram Type: Drives the Inflammatory Response in Septic Shock
Supplementary Material for: The Specific Organism: Not Bacterial Gram Type: Drives the Inflammatory Response in Septic Shock Open
Background and Hypothesis: The inflammatory response was targeted by unsuccessful therapies but ignored pathogen. We hypothesized that the inflammatory response differs according to organism in human septic shock. Materials and Methods: We…
View article: Iron: an essential nutrient for Aspergillus fumigatus and a fulcrum for pathogenesis
Iron: an essential nutrient for Aspergillus fumigatus and a fulcrum for pathogenesis Open
Purpose of review Aspergillus fumigatus is a ubiquitous saprophytic fungus that can cause life-threatening invasive aspergillosis in immunocompromised patients. Apart from the immune status of the host only a few characterized virulence fa…
View article: Microhemorrhage-associated tissue iron enhances the risk for <i>Aspergillus fumigatus</i> invasion in a mouse model of airway transplantation
Microhemorrhage-associated tissue iron enhances the risk for <i>Aspergillus fumigatus</i> invasion in a mouse model of airway transplantation Open
Increased ferric iron in allografts triggers a switch in the growth of the mold Aspergillus fumigatus from a colonizing to an invasive phenotype.
View article: Enhanced Electrochemical Sensing with Carbon Nanotubes Modified with Bismuth and Magnetic Nanoparticles in a Lab‐on‐a‐Chip
Enhanced Electrochemical Sensing with Carbon Nanotubes Modified with Bismuth and Magnetic Nanoparticles in a Lab‐on‐a‐Chip Open
Iron plays an especially important role in human physiological functions and pathological impairments. The superior properties of carbon nanotubes (CNTs) and their modification with bismuth and magnetic nanoparticles as developed in this w…
View article: Microvascular injury after lung transplantation
Microvascular injury after lung transplantation Open
Airway microvascular injury is a feature of lung transplantation that limits short-term and long-term organ health. Although some problems are attributable to a missing bronchial artery circulation, another significant issue involves alloi…
View article: Erratum for Nazik et al., Effects of Iron Chelators on the Formation and Development of Aspergillus fumigatus Biofilm
Erratum for Nazik et al., Effects of Iron Chelators on the Formation and Development of Aspergillus fumigatus Biofilm Open
Volume 59, no. 10, p. [6514–6520][1], 2015. Page 6514, abstract, line 8: the sentence “By XTT testing, DFM concentrations of <1,250 μM had no effect, whereas DFP at 2,500 μM increased biofilms forming in A. fumigatus or preformed biofilms …
View article: Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective
Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective Open
Summary Active complement mediators play a key role in graft-versus-host diseases, but little attention has been given to the angiogenic balance and complement modulation during allograft acceptance. The complement cascade releases the pow…
View article: Effects of Iron Chelators on the Formation and Development of Aspergillus fumigatus Biofilm
Effects of Iron Chelators on the Formation and Development of Aspergillus fumigatus Biofilm Open
Iron acquisition is crucial for the growth of Aspergillus fumigatus . A. fumigatus biofilm formation occurs in vitro and in vivo and is associated with physiological changes. In this study, we assessed the effects of Fe chelators on biofil…