Jadee Neff
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View article: Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity
Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity Open
Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct …
View article: Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation
Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation Open
Granulomas are classic manifestations of tuberculosis pathogenesis. They result from an ensemble of immune responses to Mycobacterium tuberculosis infection, but the identities, arrangement, cellular interactions, and regulation of the cel…
View article: A pilot study investigating the effect of pembrolizumab on the tumoral immunoprofile of newly diagnosed mullerian cancers
A pilot study investigating the effect of pembrolizumab on the tumoral immunoprofile of newly diagnosed mullerian cancers Open
A single dose of pembrolizumab increased PD-L1 modified proportion score and/or stromal interface immune cells suggesting potential for local tumor immunologic recruitment. Additionally, increases in systemic inflammation, measured by cyto…
View article: Clinicopathologic Features and the Spectrum of Myelokathexis in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Syndrome
Clinicopathologic Features and the Spectrum of Myelokathexis in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Syndrome Open
Warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome is a rare primary immunodeficiency disorder predominantly caused by germline CXCR4 variants. Bone marrow (BM) evaluation showing myelokathexis helps to establish the d…
View article: Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity
Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity Open
Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct …
View article: 56Fe-ion Exposure Increases the Incidence of Lung and Brain Tumors at a Similar Rate in Male and Female Mice
56Fe-ion Exposure Increases the Incidence of Lung and Brain Tumors at a Similar Rate in Male and Female Mice Open
The main deterrent to long-term space travel is the risk of Radiation Exposure Induced Death (REID). The National Aeronautics and Space Administration (NASA) has adopted Permissible Exposure Levels (PELs) to limit the probability of REID t…
View article: BSLM-12 IDENTIFICATION OF THE GDNF: NCAM SIGNALING AXIS AS A NOVEL TARGET AGAINST BREAST CANCER LEPTOMENINGEAL METASTASIS
BSLM-12 IDENTIFICATION OF THE GDNF: NCAM SIGNALING AXIS AS A NOVEL TARGET AGAINST BREAST CANCER LEPTOMENINGEAL METASTASIS Open
The molecular mechanisms that regulate breast cancer cell (BCC) metastasis within the leptomeninges (LM), and the adaptive mechanisms that allow tumors to thrive under cellular stressors within the nutrient-poor LM niche are poorly underst…
View article: Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis
Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis Open
The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, which limits the development of effective therapies. In this work, we show that BCCs in mice …
View article: A novel transmembrane <i>CXCR4</i> variant that expands the WHIM genotype-phenotype paradigm
A novel transmembrane <i>CXCR4</i> variant that expands the WHIM genotype-phenotype paradigm Open
CXCR4D84H is a novel transmembrane variant outside C-terminus identified in 4 unrelated patients with variable WHIM-like phenotypes
View article: Flow cytometry quantification of tumor-infiltrating lymphocytes to predict the survival of patients with diffuse large B-cell lymphoma
Flow cytometry quantification of tumor-infiltrating lymphocytes to predict the survival of patients with diffuse large B-cell lymphoma Open
Introduction Our previous studies have demonstrated that tumor-infiltrating lymphocytes (TILs), including normal B cells, T cells, and natural killer (NK) cells, in diffuse large B-cell lymphoma (DLBCL) have a significantly favorable impac…
View article: <sup>56</sup>Fe ion exposure increases the incidence of lung and brain tumors at a similar rate in male and female mice
<sup>56</sup>Fe ion exposure increases the incidence of lung and brain tumors at a similar rate in male and female mice Open
The main deterrent to long-term space travel is the risk of Radiation Exposure Induced Death (REID). The National Aeronautics and Space Administration (NASA) has adopted Permissible Exposure Levels (PELs) to limit the probability of REID t…
View article: Acute Myeloid Leukemia, Version 3.2023, NCCN Clinical Practice Guidelines in Oncology
Acute Myeloid Leukemia, Version 3.2023, NCCN Clinical Practice Guidelines in Oncology Open
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow, and/or other tissues. It is the most common form of acute leukemia among a…
View article: Dasatinib-associated follicular lymphoma in a patient with B-cell acute lymphoblastic leukaemia
Dasatinib-associated follicular lymphoma in a patient with B-cell acute lymphoblastic leukaemia Open
The tyrosine kinase inhibitor dasatinib is approved for the treatment of chronic myeloid leukaemia and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia (ALL). Patients on dasatinib can rarely develop a form of benign re…
View article: A multiple instance learning approach for detecting COVID-19 in peripheral blood smears
A multiple instance learning approach for detecting COVID-19 in peripheral blood smears Open
A wide variety of diseases are commonly diagnosed via the visual examination of cell morphology within a peripheral blood smear. For certain diseases, such as COVID-19, morphological impact across the multitude of blood cell types is still…
View article: Sequential Development of <i>JAK2</i> V617F Mutation and <i>BCR-ABL1</i> Fusion in Individual Patients With Myeloproliferative Neoplasms
Sequential Development of <i>JAK2</i> V617F Mutation and <i>BCR-ABL1</i> Fusion in Individual Patients With Myeloproliferative Neoplasms Open
Context.— Concomitant BCR-ABL1 and JAK2V617F in myeloproliferative neoplasms (MPNs) is rare, and its pathogenesis and clinical significance are unclear. Objective.— To investigate the clonal relationship between the 2 genomic alterations, …
View article: Deep Optical Blood Analysis: COVID-19 Detection as a Case Study in Next Generation Blood Screening
Deep Optical Blood Analysis: COVID-19 Detection as a Case Study in Next Generation Blood Screening Open
A wide variety of diseases are commonly diagnosed via the visual examination of cell morphology within a peripheral blood smear. For certain diseases, such as COVID-19, morphological impact across the multitude of blood cell types is still…
View article: NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021
NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021 Open
The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new informatio…
View article: Histopathologic assessment of cultured human thymus
Histopathologic assessment of cultured human thymus Open
The maintenance and propagation of complex mixtures of cells in vitro in the form of native organs or engineered organoids has contributed to understanding mechanisms of cell and organ development and function which can be translated into …
View article: Pediatric Philadelphia-positive B lymphoblastic leukemia with CD56 expression and L2 morphology: Case report and review of the literature
Pediatric Philadelphia-positive B lymphoblastic leukemia with CD56 expression and L2 morphology: Case report and review of the literature Open
We present a unique case of pediatric B lymphoblastic leukemia with Philadelphia chromosome, CD56 expression, and predominantly L2 morphology. A review of the current literature demonstrates that this distinct combination of features is ra…
View article: Hepatosplenic T-cell lymphoma with blastoid morphology in a patient with Crohn disease
Hepatosplenic T-cell lymphoma with blastoid morphology in a patient with Crohn disease Open
A 33-year-old man with Crohn disease had been treated with azathioprine for 10 years and azathioprine/adalimumab for 9 months when he began experiencing fevers, fatigue, splenomegaly, and weight loss (20 lb in 6 months).Besides anemia and …