Ashutosh P. Jadhav
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View article: Brainstorming Entrepreneurship in Brain Health
Brainstorming Entrepreneurship in Brain Health Open
The burgeoning field of brain health innovation demands a convergence of clinical insight and entrepreneurial strategy. Despite the immense global burden of neurological disorders and associated economic costs, there are precious few examp…
View article: Mechanical thrombectomy for acute ischemic stroke in a low- and middle-income country: primary outcomes from the GRASSROOT Trial
Mechanical thrombectomy for acute ischemic stroke in a low- and middle-income country: primary outcomes from the GRASSROOT Trial Open
Background and aims Access to mechanical thrombectomy for acute ischemic stroke secondary to large vessel occlusion (LVO) is severely restricted in resource-constrained environments, largely owing to the prohibitive cost of existing approv…
View article: A Systematic Review on The Role of Plant Secondary Metabolites in Combating Neurodegenerative Disorders
A Systematic Review on The Role of Plant Secondary Metabolites in Combating Neurodegenerative Disorders Open
Neurodegenerative disorders, Alzheimer, Parkinson, Huntington, among others form an array of conditions characterized by loss of neurons, cognitive impairment and motor loss, and are progressive conditions associated with a grave social, e…
View article: Neurovascular Innovation at the FDA: Pivotal Strategies to Effectively Modernize the Realization of Diagnostic, Drug, and Device Products
Neurovascular Innovation at the FDA: Pivotal Strategies to Effectively Modernize the Realization of Diagnostic, Drug, and Device Products Open
The regulatory landscape for neurovascular innovation in the United States remains fragmented, delaying the development and approval of novel diagnostics, drugs, and devices critical to addressing the burden of stroke and other neurovascul…
View article: Sexually Dimorphic Responses Reveal Multifaceted Benefits of Glibenclamide in Traumatic Brain Injury
Sexually Dimorphic Responses Reveal Multifaceted Benefits of Glibenclamide in Traumatic Brain Injury Open
Sex disparities in traumatic brain injury (TBI) remain poorly understood. Previous data suggest that males are more susceptible to acute secondary injury processes and cell death, whereas females are more vulnerable chronically. Additional…
View article: Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape Open
Alzheimer's disease (AD) is still an excessively complicated neurological disorder that impacts millions of individuals globally. The ideal defensive feature of the central nervous system (CNS) is the intimate junction of endothelial cells…
View article: Pressurized Contrast‐Related Posterior Reversible Encephalopathy Syndrome After Cerebral Digital Subtraction Angiography
Pressurized Contrast‐Related Posterior Reversible Encephalopathy Syndrome After Cerebral Digital Subtraction Angiography Open
Posterior reversible encephalopathy syndrome is a multifactorial neurological disorder characterized by clinical and neuroimaging findings. The “vasogenic theory” suggests that, in this condition, disrupted cerebrovascular autoregulation l…
View article: Endovascular Therapy in Patients With Acute Ischemic Stroke With Large Infarct: A Guideline From the Society of Vascular and Interventional Neurology
Endovascular Therapy in Patients With Acute Ischemic Stroke With Large Infarct: A Guideline From the Society of Vascular and Interventional Neurology Open
Background Recent randomized clinical trials of endovascular therapy in patients with large infarct provided new evidence in support of endovascular interventions in patients with acute ischemic stroke. The Society of Vascular and Interven…
View article: Abstract 301: Incidence And Predictors Of First Pass Effect Within 30 Minutes Of Groin Puncture
Abstract 301: Incidence And Predictors Of First Pass Effect Within 30 Minutes Of Groin Puncture Open
Title Incidence And Predictors Of First Pass Effect Within 30 Minutes Of Groin Puncture Introduction First pass effect (FPE) is an established metric of success of mechanicalthrombectomy (MT). Recently, FPE within 30 minutes (FPE30) of gro…
View article: Extracranial-intracranial bypass using a cephalic vein graft for iatrogenic internal carotid artery injury during functional endoscopic sinus surgery: illustrative case
Extracranial-intracranial bypass using a cephalic vein graft for iatrogenic internal carotid artery injury during functional endoscopic sinus surgery: illustrative case Open
BACKGROUND Injury to the internal carotid artery (ICA) during functional endoscopic sinus surgery is a rare but potentially fatal complication. Although treatment algorithms have been developed, guidelines for effectively managing iatrogen…
View article: Prognostication Following Aneurysmal Subarachnoid Hemorrhage: The Modified Hunt and Hess Grading Scale
Prognostication Following Aneurysmal Subarachnoid Hemorrhage: The Modified Hunt and Hess Grading Scale Open
Background This study proposes a modification to the traditional Hunt and Hess (tHH) grading scale for prognostication in aneurysmal subarachnoid hemorrhage (aSAH), which differentiates the most severe‐grade patients based on the presence …
View article: Control-matched octo/nonagenarian outcomes in acute basilar artery occlusions treated with mechanical thrombectomy—analysis of the PC-SEARCH thrombectomy registry
Control-matched octo/nonagenarian outcomes in acute basilar artery occlusions treated with mechanical thrombectomy—analysis of the PC-SEARCH thrombectomy registry Open
Introduction Age is often used as a predictor in determining outcomes in large vessel occlusions treated with mechanical thrombectomy. However, limited data exist for octo/nonagenarian outcomes compared to younger individuals in acute basi…
View article: Complex intracranial aneurysms: a DELPHI study to define associated characteristics
Complex intracranial aneurysms: a DELPHI study to define associated characteristics Open
The definition of aneurysm complexity varies by treatment modality. Since elements related to complexity differ between open surgery and endovascular treatment, these consensus criteria of CIAs could even guide in selecting the best treatm…
View article: Comparison of nBCA and Onyx for Embolization of Spinal Dural Arteriovenous Fistulas
Comparison of nBCA and Onyx for Embolization of Spinal Dural Arteriovenous Fistulas Open
Background Endovascular embolization can effectively treat spinal dural arteriovenous fistulas (SDAVFs). One factor limiting the success and durability of endovascular treatments is reliably casting and occluding the draining vein. We soug…
View article: Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes after Acute Ischemic Stroke: An Analysis of the <scp>DAWN</scp> Trial
Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes after Acute Ischemic Stroke: An Analysis of the <span>DAWN</span> Trial Open
Objective We aimed to assess the impact of time to endovascular thrombectomy (EVT) on clinical outcomes in the DAWN trial, while also exploring the potential effect modification of mode of stroke onset on this relationship. Methods The ass…
View article: Endovascular Thrombectomy Versus Intravenous Thrombolysis of Posterior Cerebral Artery Occlusion Stroke
Endovascular Thrombectomy Versus Intravenous Thrombolysis of Posterior Cerebral Artery Occlusion Stroke Open
Background and Purpose Posterior cerebral artery occlusion (PCAo) can cause long-term disability, yet randomized controlled trials to guide optimal reperfusion strategy are lacking. We compared the outcomes of PCAo patients treated with en…
View article: Endovascular Versus Medical Therapy in Posterior Cerebral Artery Stroke: Role of Baseline NIHSS Score and Occlusion Site
Endovascular Versus Medical Therapy in Posterior Cerebral Artery Stroke: Role of Baseline NIHSS Score and Occlusion Site Open
BACKGROUND: Acute ischemic stroke with isolated posterior cerebral artery occlusion (iPCAO) lacks management evidence from randomized trials. We aimed to evaluate whether the association between endovascular treatment (EVT) and outcomes in…
View article: Safety and Feasibility of a “Fast‐Track” Monitoring Protocol for Patients Treated With Intravenous Thrombolytic Therapy
Safety and Feasibility of a “Fast‐Track” Monitoring Protocol for Patients Treated With Intravenous Thrombolytic Therapy Open
Background Our health care systems continue to face significant strain due to chronically taxed intensive care resources. A subgroup of patients following thrombolytic stroke may not require prolonged intensive monitoring, alleviating some…
View article: Predictors of outcome and symptomatic intracranial hemorrhage in acute basilar artery occlusions: Analysis of the PC-SEARCH thrombectomy registry
Predictors of outcome and symptomatic intracranial hemorrhage in acute basilar artery occlusions: Analysis of the PC-SEARCH thrombectomy registry Open
Introduction: Recent randomized controlled trials demonstrated superiority of mechanical thrombectomy compared to medical therapy in acute basilar artery occlusions, however, little data is available to guide clinicians in functional progn…
View article: Neurointerventional Advances in 2023
Neurointerventional Advances in 2023 Open
Editorials large core stroke neuroIntervention stroke thrombectomy T his past year did not disappoint with major advancements in acute ischemic stroke (AIS) and intracranial hemorrhage (ICH) care across multiple domains.As we had anticipat…
View article: Treatment and Outcomes of Cervical Artery Dissection in Adults: A Scientific Statement From the American Heart Association
Treatment and Outcomes of Cervical Artery Dissection in Adults: A Scientific Statement From the American Heart Association Open
Cervical artery dissection is an important cause of stroke, particularly in young adults. Data conflict on the diagnostic evaluation and treatment of patients with suspected cervical artery dissection, leading to variability in practice. W…
View article: Early and late basilar artery thrombectomy time window outcomes
Early and late basilar artery thrombectomy time window outcomes Open
Importance Stroke-to-recanalization time is a strong predictor of outcomes in anterior circulation large-vessel occlusion (LVO). The authors aimed to evaluate functional outcomes in early (<6 h) vs. late (6–24 h) time windows for thromb…
View article: Enhancing student success beyond COVID-19 through professionalised academic advising: A model for identifying academic advisors for South African higher education contexts
Enhancing student success beyond COVID-19 through professionalised academic advising: A model for identifying academic advisors for South African higher education contexts Open
At South African universities, the role of academic advisors is not easily defined and there is limited literature about the attributes and characteristics required of those who occupy advising positions in the country. This article propos…