Jae Kyeom Sim
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View article: Serial KL-6 Changes in PD-1/PD-L1 Inhibitor–Related Pneumonitis in NSCLC: A Single-Center Prospective Pilot Study
Serial KL-6 Changes in PD-1/PD-L1 Inhibitor–Related Pneumonitis in NSCLC: A Single-Center Prospective Pilot Study Open
In this pilot cohort, baseline KL-6 was not clearly associated with PD-1/PD-L1 inhibitor-related pneumonitis in patients with NSCLC, whereas post-baseline increases were more frequently observed among patients who developed pneumonitis (in…
View article: Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU)
Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU) Open
Background Practice and delivery of critical care in Asia varies according to healthcare structure, income setting, and cultural factors. Identifying research priorities specific to ICU patients and healthcare workers in Asia is needed to …
View article: Fluid Resuscitation and Initial Management in Patients Presenting with Sepsis in the General Ward
Fluid Resuscitation and Initial Management in Patients Presenting with Sepsis in the General Ward Open
The optimal management of hospital-presenting sepsis remains poorly understood. We investigated the initial management in patients presenting with sepsis in the general ward, the association between fluid resuscitation and clinical outcome…
View article: Tuberculosis survivors and the risk of cardiovascular disease: analysis using a nationwide survey in Korea
Tuberculosis survivors and the risk of cardiovascular disease: analysis using a nationwide survey in Korea Open
Background Although the association between tuberculosis (TB) and cardiovascular disease (CVD) has been reported in several studies and is explained by mechanisms related to chronic inflammation, few studies have comprehensively evaluated …
View article: Prevalence of and factors associated with likely obstructive sleep apnea in individuals with airflow limitation
Prevalence of and factors associated with likely obstructive sleep apnea in individuals with airflow limitation Open
Introduction Obstructive sleep apnea (OSA) is frequently associated with airflow limitation (AFL). However, information on the prevalence of and factors associated with likely OSA in individuals with AFL in Korea is limited. Methods Data f…
View article: Association between mechanical power and intensive care unit mortality in Korean patients under pressure-controlled ventilation
Association between mechanical power and intensive care unit mortality in Korean patients under pressure-controlled ventilation Open
Background: Mechanical power (MP), which integrates ventilator variables affecting ventilator-induced lung injury, has been reported to be associated with clinical outcomes. Because the original MP equation is derived from paralyzed patien…
View article: Mechanical ventilation in patients with idiopathic pulmonary fibrosis in Korea: a nationwide cohort study
Mechanical ventilation in patients with idiopathic pulmonary fibrosis in Korea: a nationwide cohort study Open
Background/Aims: The prognosis of patients with idiopathic pulmonary fibrosis (IPF) and respiratory failure requiring mechanical ventilation is poor. Therefore, mechanical ventilation is not recommended. Recently, outcomes of mechanical ve…
View article: Impact of adjuvant chemotherapy on patients with stage IB non-small cell lung cancer with visceral pleural invasion
Impact of adjuvant chemotherapy on patients with stage IB non-small cell lung cancer with visceral pleural invasion Open
Our study shows that adjuvant chemotherapy is appropriate for patients with stage IB (1-4 cm) NSCLC with VPI, and even those with smaller tumors (1-3 cm).
View article: Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea
Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea Open
The omicron group did not demonstrate better clinical outcomes than the pre-omicron group, and exhibited significant disease severity compared to the influenza group. Considering the likely persistence of COVID-19 infections, it is imperat…
View article: Perioperative immunotherapy in stage IB-III non-small cell lung cancer: a critical review of its rationale and considerations
Perioperative immunotherapy in stage IB-III non-small cell lung cancer: a critical review of its rationale and considerations Open
Lung cancer is a dismal disease as a leading cause of overall cancer death, but the development of immune checkpoint inhibitors (ICIs) in driver gene mutation negative metastatic non-small cell lung cancer (NSCLC) is changing the paradigm …
View article: Tuberculosis survivors and the risk of cardiovascular disease: Analysis using a nationwide survey in Korea
Tuberculosis survivors and the risk of cardiovascular disease: Analysis using a nationwide survey in Korea Open
Background Although the association between tuberculosis (TB) and cardiovascular disease (CVD) has been reported in several studies and is explained by mechanisms related to chronic inflammation, few studies have comprehensively evaluated …
View article: Early Use of High-Flow Nasal Cannula in Postextubation Period: Can It Reduce Reintubation Rate? Authors’ Reply
Early Use of High-Flow Nasal Cannula in Postextubation Period: Can It Reduce Reintubation Rate? Authors’ Reply Open
See the reply "Early Use of High Flow Nasal Cannula in Postextubation Period: Can It Reduce Reintubation Rate?" on page 63.
View article: Cardiac Dysfunction Is Not Associated with Increased Reintubation Rate in Patients Treated with Post-extubation High-Flow Nasal Cannula
Cardiac Dysfunction Is Not Associated with Increased Reintubation Rate in Patients Treated with Post-extubation High-Flow Nasal Cannula Open
Background: Cardiac dysfunction patients have long been considered at high risk of reintubation. However, it is based on past studies in which only conventional oxygen therapy was applied after extubation. We investigated association betwe…
View article: Comparison of clinical characteristics and hospital mortality in critically ill patients without COVID-19 before and during the COVID-19 pandemic: a multicenter, retrospective, propensity score-matched study
Comparison of clinical characteristics and hospital mortality in critically ill patients without COVID-19 before and during the COVID-19 pandemic: a multicenter, retrospective, propensity score-matched study Open
Background The high transmission and fatality rates of coronavirus disease 2019 (COVID-19) strain intensive care resources and affect the treatment and prognosis of critically ill patients without COVID-19. Therefore, this study evaluated …
View article: An Integrated Model including the ROX Index to Predict the Success of High-Flow Nasal Cannula Use after Planned Extubation: A Retrospective Observational Cohort Study
An Integrated Model including the ROX Index to Predict the Success of High-Flow Nasal Cannula Use after Planned Extubation: A Retrospective Observational Cohort Study Open
High-flow nasal cannula (HFNC) therapy is commonly used to prevent reintubation after planned extubation. In clinical practice, there are no appropriate tools to evaluate whether HFNC therapy was successful or failed after planned extubati…
View article: Predictors of residual pulmonary vascular obstruction after anticoagulation monotherapy in patients with intermediate-risk pulmonary embolism
Predictors of residual pulmonary vascular obstruction after anticoagulation monotherapy in patients with intermediate-risk pulmonary embolism Open
Anticoagulation monotherapy did not seem to be a sufficient treatment to reduce RPVO, but the outcome was similar to that of patients treated with other therapies. Therefore, considering the risk-benefit ratio, we do not need to change the…
View article: Prognostic marker for severe acute exacerbation of chronic obstructive pulmonary disease: analysis of diffusing capacity of the lung for carbon monoxide (DLCO) and forced expiratory volume in one second (FEV1)
Prognostic marker for severe acute exacerbation of chronic obstructive pulmonary disease: analysis of diffusing capacity of the lung for carbon monoxide (DLCO) and forced expiratory volume in one second (FEV1) Open
View article: Prognostic Marker for Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Analysis of Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) and Forced Expiratory Volume in One Second (FEV1)
Prognostic Marker for Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Analysis of Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) and Forced Expiratory Volume in One Second (FEV1) Open
Background: It is important to assess the prognosis and classify patients in chronic obstructive pulmonary disease (COPD) and acute exacerbation of COPD (AECOPD) treatment. Recently, it was suggested that diffusing capacity of the lung for…
View article: Prognostic Marker for Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Analysis of Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) and Forced Expiratory Volume in One Second (FEV1)
Prognostic Marker for Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Analysis of Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) and Forced Expiratory Volume in One Second (FEV1) Open
Background: It is important to assess the prognosis and classify patients in chronic obstructive pulmonary disease (COPD) and acute exacerbation of COPD (AECOPD) treatment. Recently, it was suggested that diffusing capacity of the lung for…
View article: Change in management and outcome of mechanical ventilation in Korea: a prospective observational study
Change in management and outcome of mechanical ventilation in Korea: a prospective observational study Open
Background/Aims: There are few studies describing contemporary status of mechanical ventilation in Korea. We investigated changes in management and outcome of mechanical ventilation in Korea.Methods: International, prospective observationa…
View article: Intensive care unit-acquired hyponatremia in critically ill medical patients
Intensive care unit-acquired hyponatremia in critically ill medical patients Open
View article: Relationship between Particulate Matter (PM<sub>10</sub>) and Airway Inflammation Measured with Exhaled Nitric Oxide Test in Seoul, Korea
Relationship between Particulate Matter (PM<sub>10</sub>) and Airway Inflammation Measured with Exhaled Nitric Oxide Test in Seoul, Korea Open
Purpose . Particulate matter (PM) is increasing every year in Asia. It is not fully understood how the airway is affected when inhaling PM. We investigated the correlation between particulate matter with a diameter of less than 10 μ m (PM …
View article: EP23.11: Intrapartum ultrasound is useful in the management of prolonged second stage of labour
EP23.11: Intrapartum ultrasound is useful in the management of prolonged second stage of labour Open
Angle of progression (AoP) is an accurate and reproducible parameter for assessment of fetal descent. The aim of this study was to evaluate the usefulness of the AoP in the management of prolonged second stage of labour by analysing the ch…
View article: Clinical and molecular characteristics of pulmonary sarcomatoid carcinoma
Clinical and molecular characteristics of pulmonary sarcomatoid carcinoma Open
PSC was more common in males, smokers, and the elderly, with worse prognosis than ordinary NSCLC; chemotherapy response was favorable, and EGFR mutation status and PD-L1 expression may offer more therapeutic options.
View article: Severe Endobronchial Inflammation Induced by Aspiration of a Ferrous Sulfate Tablet
Severe Endobronchial Inflammation Induced by Aspiration of a Ferrous Sulfate Tablet Open
Iron supplements such as ferrous sulfate tablets are usually used to treat iron-deficiency anemia in some elderly patients with primary neurologic disorders or decreased gag reflexes due to stroke, senile dementia, or parkinsonism. While t…
View article: Pulmonary Sarcoidosis Induced by Adalimumab: A Case Report and Literature Review
Pulmonary Sarcoidosis Induced by Adalimumab: A Case Report and Literature Review Open
To the Editor:
Adalimumab is an anti-tumor necrosis factor-alpha (TNF-α) monoclonal antibody that is widely used in autoimmune diseases including rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease and sarcoidosis. …
View article: Nasogastric Tube Syndrome: Why Is It Important in the Intensive Care Unit?
Nasogastric Tube Syndrome: Why Is It Important in the Intensive Care Unit? Open
Although the nasogastric tube (NGT) is widely used in critically ill patients, most intensivists do not give much thought to it or its possible complications. NGT syndrome is a rare but fatal complication characterized by throat pain and v…