Explanipedia

Increased fibrin deposition in the brains of individuals with Down syndrome and Alzheimer’s disease Open

Annie Du, Lisi Flores Aguilar, Natalie C. Edwards, Patrick J. Lao, Jae Kyu Ryu , et al. · 2024

Background Individuals with Down syndrome (DS) have an increased genetic risk of developing Alzheimer’s disease (AD), with most adults developing AD neuropathology in their 40s. Despite having a low frequency of systemic vascular risk fact…

Fibrin drives thromboinflammation and neuropathology in COVID-19 Open

Jae Kyu Ryu, Zhaoqi Yan, Mauricio Montaño, Elif G. Sözmen, Karuna Dixit , et al. · 2024

Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood–brain barrier disruption Open

Olivia Weaver, Dawn Gano, Yungui Zhou, Hosung Kim, Reshmi Tognatta , et al. · 2024

Cerebellar injury in preterm infants with central nervous system (CNS) hemorrhage results in lasting neurological deficits and an increased risk of autism. The impact of blood-induced pathways on cerebellar development remains largely unkn…

Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation Open

Terry Dean, Andrew S. Mendiola, Zhaoqi Yan, Rosa Meza-Acevedo, Belinda Cabriga , et al. · 2024

A novel mouse model of cerebral adrenoleukodystrophy highlights NLRP3 activity in lesion pathogenesis Open

Ezzat Hashemi, Isha N. Srivastava, Alejandro Aguirre, Ezra Tilahan Yoseph, Esha Kaushal , et al. · 2023

Objective We sought to create and characterize a mouse model of the inflammatory, cerebral demyelinating phenotype of X-linked adrenoleukodystrophy (ALD) that would facilitate the study of disease pathogenesis and therapy development. We a…

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling Open

Andrew S. Mendiola, Zhaoqi Yan, Karuna Dixit, Jeffrey R. Johnson, Mehdi Bouhaddou , et al. · 2023

Blood protein extravasation through a disrupted blood–brain barrier and innate immune activation are hallmarks of neurological diseases and emerging therapeutic targets. However, how blood proteins polarize innate immune cells remains larg…

Continuous sulfur removal process Open

Jae Kyu Ryu · 2023

A continuous process for the removal of hydrogen sulfide from a gas stream using a membrane comprising a metal oxide deposited on a porous support is disclosed.

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy Open

Jae Kyu Ryu, Elif G. Sözmen, Karuna Dixit, Mauricio Montaño, Yusuke Matsui , et al. · 2021

Blood clots are a central feature of coronavirus disease-2019 (COVID-19) and can culminate in pulmonary embolism, stroke, and sudden death. However, it is not known how abnormal blood clots form in COVID-19 or why they occur even in asympt…

BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis Open

Mark A. Petersen, Reshmi Tognatta, Anke Meyer‐Franke, Eric A. Bushong, Andrew S. Mendiola , et al. · 2021

Extrinsic inhibitors at sites of blood–brain barrier disruption and neurovascular damage contribute to remyelination failure in neurological diseases. However, therapies to overcome the extrinsic inhibition of remyelination are not widely …

Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma Open

Justin Chan, Mario Merlini, Hua-Xin Gao, Andrew S. Mendiola, Katerina Akassoglou , et al. · 2021

Microglial Gi-dependent dynamics regulate brain network hyperexcitability Open

Mario Merlini, Victoria A. Rafalski, Keran Ma, Keunyoung Kim, Eric A. Bushong , et al. · 2020

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation Open

Andrew S. Mendiola, Jae Kyu Ryu, Sophia Bardehle, Anke Meyer‐Franke, Kenny Kean‐Hooi Ang , et al. · 2020

A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling Open

Eirini Vagena, Jae Kyu Ryu, Bernat Baeza-Raja, Nicola M. Walsh, Catriona Syme , et al. · 2019

Obesity is associated with an increased risk of depression. The aim of the present study was to investigate whether obesity is a causative factor for the development of depression and what is the molecular pathway(s) that link these two di…

Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis Open

Cory M. Willis, Alexandra M. Nicaise, Antoine Ménoret, Jae Kyu Ryu, Andrew S. Mendiola , et al. · 2019

Extracellular vesicles (EVs) are emerging as potent mediators of intercellular communication with roles in inflammation and disease. In this study, we examined the role of EVs from blood plasma (pEVs) in an experimental autoimmune encephal…

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model Open

Mario Merlini, Victoria A. Rafalski, Pamela E. Rios Coronado, Thomas M. Gill, Maya Ellisman , et al. · 2019

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration Open

Jae Kyu Ryu, Victoria A. Rafalski, Anke Meyer‐Franke, Ryan A. Adams, Suresh B. Poda , et al. · 2018

Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer's disease (AD). However, the mecha…

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics Open

Mark A. Petersen, Jae Kyu Ryu, Katerina Akassoglou · 2018

Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination Open

Nathanael J. Lee, Seung-Kwon Ha, Pascal Sati, Martina Absinta, Nicholas J. Luciano , et al. · 2018

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. Although it has been extensively studied, the proximate trigger of the immune response remains uncertain. Experimental autoimmune encephalomyelitis …

A High-fat Diet Promotes Depression-like Behavior in Mice by Suppressing Hypothalamic PKA Signaling Open

Eirini Vagena, Jae Kyu Ryu, Bernat Baeza-Raja, Nicola M. Walsh, Catriona Syme , et al. · 2018

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage Open

Mark A. Petersen, Jae Kyu Ryu, Kae-Jiun Chang, Ainhoa Etxeberría, Sophia Bardehle , et al. · 2017

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism Open

Tao Xu, Kelly M. Stewart, Xiaohu Wang, Kai Liu, Min Xie , et al. · 2017

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity Open

Eva Czirr, Nicholas A. Castello, Kira I. Mosher, Joseph M. Castellano, Izumi V. Hinkson , et al. · 2017

Recent genetic evidence supports a link between microglia and the complement system in Alzheimer’s disease (AD). In this study, we uncovered a novel role for the microglial complement receptor 3 (CR3) in the regulation of soluble β-amyloid…

Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease Open

Maureen A. Shaw, Zhen Gao, Kathryn E. McElhinney, Sherry Thornton, Matthew J. Flick , et al. · 2017

Multiple sclerosis (MS) is a neuroinflammatory, demyelinating disease of the CNS. Fibrinogen deposition at sites of blood–brain barrier breakdown is a prominent feature of neuroinflammatory disease and contributes to disease severity. Plas…

Pyruvate blocks blood-brain barrier disruption, lymphocyte infiltration and immune response in excitotoxic brain injury. Open

Jae Kyu Ryu, James G. McLarnon · 2016

The effects of pyruvate, the end metabolite of glycolysis, on blood-brain barrier (BBB) impairment and immune reactivity were examined in the quinolinic acid (QA)-injected rat striatum. Extensive disruption of BBB was observed at 7 d post …

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity Open

Bernat Baeza-Raja, Benjamin D. Sachs, Pingping Li, Christian Frank, Eirini Vagena , et al. · 2015

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation Open

Jae Kyu Ryu, Mark A. Petersen, Sara G. Murray, Kim M. Baeten, Anke Meyer‐Franke , et al. · 2015

Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease Open

Jae Kyu Ryu, T Cho, Hyun B. Choi, Nattinee Jantaratnotai, James G. McLarnon · 2015

Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions Open

Christian Schachtrup, Jae Kyu Ryu, Könül Mammadzada, Md. Abdullah Saeed Khan, Peter M. Carlton , et al. · 2015

SIRT1 deacetylates RORγt and enhances Th17 cell generation Open

Hyung W. Lim, Seung Goo Kang, Jae Kyu Ryu, Birgit Schilling, Mingjian Fei , et al. · 2015

© 2015 Lim et al.The balance of effector and regulatory T cell function, dependent on multiple signals and epigenetic regulators, is critical to immune self-tolerance. Dysregulation of T helper 17 (Th17) effector cells is associated with m…

SIRT1 deacetylates RORγt and enhances Th17 cell generation Open

Hyung W. Lim, Seung Goo Kang, Jae Kyu Ryu, Birgit Schilling, Mingjian Fei , et al. · 2015

The balance of effector and regulatory T cell function, dependent on multiple signals and epigenetic regulators, is critical to immune self-tolerance. Dysregulation of T helper 17 (Th17) effector cells is associated with multiple autoimmun…

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