Jae‐Chul Pyun
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View article: Development and immunogenicity of adenoviral Fc-fused FMDV virus-like particle vaccine in swine
Development and immunogenicity of adenoviral Fc-fused FMDV virus-like particle vaccine in swine Open
Foot-and-mouth disease (FMD) remains a major threat to global livestock health, and current inactivated vaccines face limitations in biosafety and cross-protection. Virus-like particle (VLP) -based vaccines offer a safer alternative, howev…
View article: ColorI-DT: An open-source tool for the quantitative evaluation of differences in microscopy color images
ColorI-DT: An open-source tool for the quantitative evaluation of differences in microscopy color images Open
View article: Transmembrane protease serine 2 (TMPRSS2) inhibitors screened from an Fv-antibody library for preventing SARS-CoV-2 infection
Transmembrane protease serine 2 (TMPRSS2) inhibitors screened from an Fv-antibody library for preventing SARS-CoV-2 infection Open
TMPRSS2 inhibitors used to prevent SARS-CoV-2 infection, which were screened from an Fv-antibody library.
View article: Penicillin-like mimotopes from autodisplayed Fv-antibody library inhibiting β-lactamase activity
Penicillin-like mimotopes from autodisplayed Fv-antibody library inhibiting β-lactamase activity Open
Penicillin-like mimotopes were screened from an Fv-antibody library and their β-lactamase inhibition activity was evaluated using colorimetric assay.
View article: Radiomic analysis of 3D spheroids using 2D brightfield images
Radiomic analysis of 3D spheroids using 2D brightfield images Open
View article: Exosomal miR-6126 as a novel therapeutic target for overcoming resistance of anti-cancer effect in hepatocellular carcinoma
Exosomal miR-6126 as a novel therapeutic target for overcoming resistance of anti-cancer effect in hepatocellular carcinoma Open
View article: Screened Fv-Antibodies against the Angiotensin-Converting Enzyme 2 (ACE2) Receptor Neutralizing the Infection of SARS-CoV-2
Screened Fv-Antibodies against the Angiotensin-Converting Enzyme 2 (ACE2) Receptor Neutralizing the Infection of SARS-CoV-2 Open
For the prevention of SARS-CoV-2 infection, four Fv-antibodies with binding affinity for the ACE2 receptor were screened from an Fv-antibody library. The screened Fv-antibodies were expressed as soluble proteins and estimated to have a hig…
View article: Reduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant infection by blocking the epidermal growth factor receptor (EGFR) pathway
Reduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant infection by blocking the epidermal growth factor receptor (EGFR) pathway Open
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants presents challenges in global efforts to transition from the pandemic to an endemic stage. The spike protein of the SARS-CoV-2 virus, which is pivotal f…
View article: Two-dimensional segmentation fusion tool: an extensible, free-to-use, user-friendly tool for combining different bidimensional segmentations
Two-dimensional segmentation fusion tool: an extensible, free-to-use, user-friendly tool for combining different bidimensional segmentations Open
Introduction: In several fields, the process of fusing multiple two-dimensional (2D) closed lines is an important step. For instance, this is fundamental in histology and oncology in general. The treatment of a tumor consists of numerous s…
View article: Impact of glucose metabolism on PD-L1 expression in sorafenib-resistant hepatocellular carcinoma cells
Impact of glucose metabolism on PD-L1 expression in sorafenib-resistant hepatocellular carcinoma cells Open
Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer-related mortality worldwide. Programmed cell death ligand-1 (PD-L1) is an immune checkpoint protein that binds to programmed cell death-1 (PD-1), which is expressed in act…
View article: Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site
Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site Open
Fv-antibodies targeting the PPC region of SARS-CoV-2 to prevent infection, screened from an Fv-antibody library (displayed on outer membrane of E. coli cell).
View article: Monoamine Oxidase-A (MAO-A) Inhibitors Screened from the Autodisplayed Fv-Antibody Library
Monoamine Oxidase-A (MAO-A) Inhibitors Screened from the Autodisplayed Fv-Antibody Library Open
Serotonin-like mimotopes were screened from the Fv-antibody library to be used as inhibitors against monoamine oxidase A (MAO-A). The Fv-antibody [corresponding to the VH region of immunoglobulin G (IgG)] consists of three compl…
View article: Screening of Pancreatic Ribonuclease A Inhibitors from an Autodisplayed Fv-Antibody Library
Screening of Pancreatic Ribonuclease A Inhibitors from an Autodisplayed Fv-Antibody Library Open
Pancreatic ribonuclease A (RNase A) inhibitors were screened from an autodisplayed Fv-antibody library, which was prepared by randomizing amino acid sequences of the third complementary-determining region (CDR3) within the heavy chain vari…
View article: Novel small molecule-mediated restoration of the surface expression and anion exchange activity of mutated pendrin causing Pendred syndrome and DFNB4
Novel small molecule-mediated restoration of the surface expression and anion exchange activity of mutated pendrin causing Pendred syndrome and DFNB4 Open
Variants in SLC26A4 (pendrin) are the most common reasons for genetic hearing loss and vestibular dysfunction in East Asians. In patients with Pendred syndrome and DFNB4 (autosomal recessive type of genetic hearing loss 4), caused by varia…
View article: Effects of hole transporting PEDOT:PSS on the photoemission of upconverted hot electron in Mn-doped CdS/ZnS quantum dots
Effects of hole transporting PEDOT:PSS on the photoemission of upconverted hot electron in Mn-doped CdS/ZnS quantum dots Open
In this work, we investigated the effect of hole transporting poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) interfacing with Mn-doped CdS/ZnS quantum dots (QDs) deposited on an indium tin oxide (ITO) substrate on the p…
View article: Immunoaffinity biosensors for the detection of SARS-CoV-1 using screened Fv-antibodies from an autodisplayed Fv-antibody library
Immunoaffinity biosensors for the detection of SARS-CoV-1 using screened Fv-antibodies from an autodisplayed Fv-antibody library Open
View article: DEEP LEARNING-BASED TOOL FOR MORPHOTYPIC ANALYSIS OF 3D MULTICELLULAR SPHEROIDS
DEEP LEARNING-BASED TOOL FOR MORPHOTYPIC ANALYSIS OF 3D MULTICELLULAR SPHEROIDS Open
Introduction: Three-dimensional (3D) multicellular spheroids are fundamental in vitro tools for studying in vivo tissues. Volume is the main feature used for evaluating the drug/treatment effects, but several other features can be estimate…
View article: Development of Novel Outer Membrane Vesicle-Nanoparticles (Omv-Nps) Using Bioorthogonal Chemistry
Development of Novel Outer Membrane Vesicle-Nanoparticles (Omv-Nps) Using Bioorthogonal Chemistry Open
View article: A vertically paired electrode for redox cycling and its application to immunoassays
A vertically paired electrode for redox cycling and its application to immunoassays Open
An electrochemical immunoassay based on the redox cycling method was presented using vertically paired electrodes (VPEs), which were fabricated using PEDOT:PSS as an electrode material and parylene-C as a dielectric layer.
View article: One-step immunoassay based on switching peptides for analyzing ochratoxin A in wines
One-step immunoassay based on switching peptides for analyzing ochratoxin A in wines Open
A one-step immunoassay is presented for the detection of ochratoxin A (OTA) using an antibody complex with switching peptides. Because the switching peptides (fluorescence-labeled) were able to bind the frame region of antibodies (IgGs), t…
View article: Overexpression of CYP11A1 recovers cell cycle distribution in renal cell carcinoma Caki-1
Overexpression of CYP11A1 recovers cell cycle distribution in renal cell carcinoma Caki-1 Open
Background Clear cell renal carcinoma is commonly known for its metastasis propensity to outspread to other organs and is asymptomatic in the early stage. Recent studies have shown that deficiencies in CYP11A1 expression can lead to fatal …
View article: Extracellular histones aggravate autoimmune arthritis by lytic cell death
Extracellular histones aggravate autoimmune arthritis by lytic cell death Open
Although recent studies have demonstrated a proinflammatory effect of extracellular histones in sepsis via endothelial cytotoxicity, little is known about their contribution to autoimmune arthritis. Therefore, we investigated the role of e…
View article: One-Step Homogeneous Immunoassay for the Detection of Influenza Virus Using Switching Peptide and Graphene Quencher
One-Step Homogeneous Immunoassay for the Detection of Influenza Virus Using Switching Peptide and Graphene Quencher Open
View article: Overexpression of CYP11A1 recovers cell cycle distribution in renal cell carcinoma Caki-1
Overexpression of CYP11A1 recovers cell cycle distribution in renal cell carcinoma Caki-1 Open
Background Clear cell renal carcinoma is commonly known for its metastasis propensity to outspread to other organs and does not exhibit symptoms in the early stage. Recent studies have shown that deficiencies in CYP11A1 expression can lead…
View article: Laser desorption/ionization mass spectrometry of L-thyroxine (T4) using combi-matrix of α-cyano-4-hydroxycinnamic acid (CHCA) and graphene
Laser desorption/ionization mass spectrometry of L-thyroxine (T4) using combi-matrix of α-cyano-4-hydroxycinnamic acid (CHCA) and graphene Open
View article: Quantitative analysis of vitamin D using m/MALDI-TOF mass spectrometry based on a parylene matrix chip
Quantitative analysis of vitamin D using m/MALDI-TOF mass spectrometry based on a parylene matrix chip Open
View article: Capacitive biosensor based on vertically paired electrodes for the detection of SARS-CoV-2
Capacitive biosensor based on vertically paired electrodes for the detection of SARS-CoV-2 Open
View article: Recyclable, Antibacterial, Isoporous Through-Hole Membrane Air Filters with Hydrothermally Grown ZnO Nanorods
Recyclable, Antibacterial, Isoporous Through-Hole Membrane Air Filters with Hydrothermally Grown ZnO Nanorods Open
Reusable, antibacterial, and photocatalytic isoporous through-hole air filtration membranes have been demonstrated based on hydrothermally grown ZnO nanorods (NRs). High-temperature (300~375 °C) stability of thermoset-based isoporous throu…
View article: Quantitative analysis of galactose using LDI-TOF MS based on a TiO2 nanowire chip
Quantitative analysis of galactose using LDI-TOF MS based on a TiO2 nanowire chip Open
View article: Rapid Analysis of Bacterial Contamination in Platelets without Pre-Enrichment Using Pig Serum-Derived Antibodies
Rapid Analysis of Bacterial Contamination in Platelets without Pre-Enrichment Using Pig Serum-Derived Antibodies Open
As the shelf life of platelets collected from donated blood is very short, approximately 5 days, the determination of bacterial contamination in platelets has become necessary. In this study, rapid analysis of Gram-positive and Gram-negati…