Jae‐Bum Jun
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View article: The future of Korean rheumatology
The future of Korean rheumatology Open
Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect various organs. Juvenile-onset SLE (jSLE) may be more severe than the adult-onset form, but the diagnosis and classification remain challenging due to the complex…
View article: Assessment of disease activity and quality of life of Korean patients with rheumatoid arthritis
Assessment of disease activity and quality of life of Korean patients with rheumatoid arthritis Open
The management of rheumatoid arthritis (RA) follows a treat-to-target approach, as recommended by guidelines from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). RA treatment recommendations i…
View article: Association of HLA-DRB1 locus with treatment response to abatacept or TNF inhibitors in patients with seropositive rheumatoid arthritis
Association of HLA-DRB1 locus with treatment response to abatacept or TNF inhibitors in patients with seropositive rheumatoid arthritis Open
The strongest genetic risk factor for rheumatoid arthritis (RA) has been known as HLA-DRB1 based on amino acid positions 11, 71, and 74. This study analyzed the association between specific HLA-DRB1 locus and treatment response to abatacep…
View article: <i>Bifidobacterium longum</i> RAPO Attenuates Dermal and Pulmonary Fibrosis in a Mouse Model of Systemic Sclerosis through Macrophage Modulation and Growth of Short-Chain Fatty Acid Producers
<i>Bifidobacterium longum</i> RAPO Attenuates Dermal and Pulmonary Fibrosis in a Mouse Model of Systemic Sclerosis through Macrophage Modulation and Growth of Short-Chain Fatty Acid Producers Open
Systemic sclerosis (SSc) is a complex autoimmune disease with an unclear etiology and no effective treatments. Recent research has suggested involvement of the microbiome in SSc pathogenesis. This study aimed to identify specific microbial…
View article: Korean guidelines for the management of gout
Korean guidelines for the management of gout Open
Gout is the most common form of arthritis, with the prevalence increasing worldwide. The present treatment guidelines provide recommendations for the appropriate treatment of acute gout, management during the inter-critical period, and pre…
View article: Transcriptomic network analysis reveals key drivers of response to anti-TNF biologics in patients with rheumatoid arthritis
Transcriptomic network analysis reveals key drivers of response to anti-TNF biologics in patients with rheumatoid arthritis Open
Objective Anti-TNF biologics have been widely used to ameliorate disease activity in patients with RA. However, a large fraction of patients show a poor response to these agents. Moreover, no clinically applicable predictive biomarkers hav…
View article: LO-042 High genetic risk load for systemic lupus erythematosus in antinuclear antibody-positive individuals at the preclinical stage
LO-042 High genetic risk load for systemic lupus erythematosus in antinuclear antibody-positive individuals at the preclinical stage Open
Background The antinuclear antibody (ANA)-positive asymptomatic individuals are at higher risk of developing systemic lupus erythematosus (SLE). However, the genetic burden for SLE in preclinical ANA-positive phase remains largely unknown.…
View article: Korean guidelines for the management of gout
Korean guidelines for the management of gout Open
Gout is the most common form of arthritis, with the prevalence increasing worldwide. The present treatment guidelines provide recommendations for the appropriate treatment of acute gout, management during the inter-critical period, and pre…
View article: Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis
Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis Open
Objective This phase 3 study was undertaken to investigate the efficacy and safety of lenabasum, a cannabinoid type 2 receptor agonist, in patients with diffuse cutaneous systemic sclerosis (dcSSc). Methods A multinational double‐blind stu…
View article: Factors associated with selection of targeted therapy in patients with rheumatoid arthritis
Factors associated with selection of targeted therapy in patients with rheumatoid arthritis Open
Objective Deciding which drug to choose for targeted therapy is an important step in sequential treatment for rheumatoid arthritis (RA). This study aimed to identify factors for selecting Janus kinase inhibitors (JAKis) rather than biologi…
View article: <i>MUC5B</i> promoter variant rs35705950, rare but significant susceptibility locus in rheumatoid arthritis-interstitial lung disease with usual interstitial pneumonia in Asian populations
<i>MUC5B</i> promoter variant rs35705950, rare but significant susceptibility locus in rheumatoid arthritis-interstitial lung disease with usual interstitial pneumonia in Asian populations Open
Background MUC5B variant rs35705950 is the common and most significant risk variant for rheumatoid arthritis-interstitial lung disease (RA-ILD) in Western populations. However, little is known about its significant association with RA-ILD …
View article: Altered Serum Uric Acid Levels in Kidney Disorders
Altered Serum Uric Acid Levels in Kidney Disorders Open
Serum uric acid levels are altered by kidney disorders because the kidneys play a dominant role in uric acid excretion. Here, major kidney disorders which accompany hyperuricemia or hypouricemia, including their pathophysiology, are discus…
View article: Clinical Characteristics of Rheumatoid Arthritis Patients with Interstitial Lung Disease: Baseline Data of a Single-Centre Prospective Cohort
Clinical Characteristics of Rheumatoid Arthritis Patients with Interstitial Lung Disease: Baseline Data of a Single-Centre Prospective Cohort Open
Objectives: To establish a prospective cohort for rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) and to identify their clinical features compared to those without ILD. Methods: With a multidisciplinary collaborativ…
View article: Risk factors for herpes zoster in Korean patients with rheumatoid arthritis treated with JAK inhibitor: a nested case–control study
Risk factors for herpes zoster in Korean patients with rheumatoid arthritis treated with JAK inhibitor: a nested case–control study Open
Objective To determine the risk of herpes zoster (HZ) in Korean patients with rheumatoid arthritis (RA) receiving Janus kinase inhibitors (JAKis). Methods We performed a nested case–control study with 1:10 matching for sex and age using si…
View article: Clinical Significance of Elevated Serum Caspase-1 Levels in Patients With Ankylosing Spondylitis
Clinical Significance of Elevated Serum Caspase-1 Levels in Patients With Ankylosing Spondylitis Open
Sang-Hyon Kim, M.D., Ph.D., Ji-Hyun Lee, M.S., Hye-Jin Jeong, M.D., Ji-Min Kim, M.D., Ph.D., Won-Ki Baek, M.D., Ph.D., Tae-Hwan Kim, M.D., Ph.D., Jae-Bum Jun, M.D., Ph.D., and Chang-Nam Son, M.D., Ph.D.. Ann Lab Med 2022;42:293-5. https://…
View article: J-shaped Relationship Between Chronic Kidney Disease and Serum Uric Acid Levels: A Cross-sectional Study on the Korean Population
J-shaped Relationship Between Chronic Kidney Disease and Serum Uric Acid Levels: A Cross-sectional Study on the Korean Population Open
The OR of reduced renal function according to uric acid levels formed a J-shaped curve in both genders.
View article: Reliability and Quality of Korean YouTube Videos for Education Regarding Gout
Reliability and Quality of Korean YouTube Videos for Education Regarding Gout Open
Approximately 75% of YouTube videos that contain educational material regarding gout were useful; however, we observed some inaccuracies in the medical information provided. Healthcare professionals should closely monitor media content and…
View article: Fracture Risk and Its Prevention Patterns in Korean Patients with Polymyalgia Rheumatica: a Retrospective Cohort Study
Fracture Risk and Its Prevention Patterns in Korean Patients with Polymyalgia Rheumatica: a Retrospective Cohort Study Open
The incidence rate of fractures in Korean patients with PMR was 3.93/100 PYs. Female sex, advanced age, longer follow-up duration, and increased glucocorticoid dose are risk factors for osteoporotic fracture.
View article: Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970
Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970 Open
The distribution of SUA levels and prevalence of hyperuricemia and hypouricemia differed according to age and sex. Age and sex should be considered in studies on uric acid-related diseases.
View article: Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis
Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis Open
This study identified six new RA-associated loci that contributed to better understanding of the genetic aetiology and biology in RA.
View article: Analysis of Asian Mitochondrial DNA Haplogroups Associated With the Progression of Knee Osteoarthritis in Koreans
Analysis of Asian Mitochondrial DNA Haplogroups Associated With the Progression of Knee Osteoarthritis in Koreans Open
Bon San Koo, M.D., Yoonah Song, M.D., Seunghun Lee, M.D., Ph.D., Yoon-Kyoung Sung, M.D., Ph.D., Kyoung-Jin Shin, M.D., Ph.D., Nam H. Cho, M.D., Ph.D., Jae-Bum Jun, M.D., Ph.D.. J Rheum Dis 2020;27:168-73. https://doi.org/10.4078/jrd.2020.2…
View article: The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment
The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment Open
In an elderly population with cognitive impairment, we investigated the association between serum uric acid (sUA) and serum homocysteine (sHcy), known risk factors for cerebrovascular disease. We also investigated the potential effect of t…