Jae‐Hoon Ko
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View article: Impaired and restored CD8+ T cell responses to a sequentially mutated spike epitope in Omicron variants
Impaired and restored CD8+ T cell responses to a sequentially mutated spike epitope in Omicron variants Open
In the post-pandemic era, SARS-CoV-2 variants continue to circulate and evolve. T cell-mediated immunity is essential for antiviral defense, but its evasion by emerging variants remains poorly defined. In this study, we screened spike-deri…
View article: Case Report: Proximal duodenal mural mass causing extrahepatic biliary obstruction and reactive pancreatic changes in a dog
Case Report: Proximal duodenal mural mass causing extrahepatic biliary obstruction and reactive pancreatic changes in a dog Open
A 10-year-old castrated male Yorkshire Terrier was referred for acute vomiting and inappetence. Blood tests revealed elevated hepatobiliary and pancreatic enzymes. Ultrasonography identified a hypoechoic mural mass in the cranial duodenum …
View article: Clinical Outcome of Rifabutin-based Treatment for Pulmonary Tuberculosis in Solid Organ Transplant Recipients
Clinical Outcome of Rifabutin-based Treatment for Pulmonary Tuberculosis in Solid Organ Transplant Recipients Open
Backgrounds Rifabutin is often used instead of rifampin to treat tuberculosis (TB) in solid organ transplant recipients (SOTRs) due to fewer drug interactions with immunosuppressants. However, data on its efficacy are limited. Methods A re…
View article: Evaluation of the VITEK 2 AST-N439 card for susceptibility testing of novel β-lactam/β-lactamase inhibitor combinations and colistin in carbapenem-non-susceptible gram-negative bacilli
Evaluation of the VITEK 2 AST-N439 card for susceptibility testing of novel β-lactam/β-lactamase inhibitor combinations and colistin in carbapenem-non-susceptible gram-negative bacilli Open
We assessed the performance of the VITEK 2 AST-N439 card for susceptibility testing of novel β-lactam/β-lactamase inhibitor (BL/BLI) combinations and colistin in carbapenem-non-susceptible gram-negative isolates. A total of 425 clinical is…
View article: Evaluation of the cobas SARS-CoV-2 & Influenza A/B v2 assay for detecting SARS-CoV-2 and influenza A and B viruses in nasopharyngeal swab specimens
Evaluation of the cobas SARS-CoV-2 & Influenza A/B v2 assay for detecting SARS-CoV-2 and influenza A and B viruses in nasopharyngeal swab specimens Open
Accurate and rapid diagnostic assays that simultaneously detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A/B are crucial for effective clinical management and infection control. In the present study, we ev…
View article: Comparison of conventional culture and automated blood culture system for microbiologic diagnosis of pleural infection
Comparison of conventional culture and automated blood culture system for microbiologic diagnosis of pleural infection Open
Microbiological diagnosis of pleural infection is often hindered by the low sensitivity of conventional culture. The automated blood culture system (ABCS) has been shown to improve diagnostic sensitivity for the culture of non-blood specim…
View article: Diminishing reactogenicity with preserved immunogenicity in COVID-19 vaccines: A longitudinal observation from primary to updated booster vaccine cohorts
Diminishing reactogenicity with preserved immunogenicity in COVID-19 vaccines: A longitudinal observation from primary to updated booster vaccine cohorts Open
The observed decline in reactogenicity, alongside sustained immunological responses, supports the safety and efficacy of annual COVID-19 booster vaccination programs.
View article: Enhanced Biofilm Disruption in Methicillin-Resistant Staphylococcus aureus Using Rifampin and Fluoroquinolone Combinations
Enhanced Biofilm Disruption in Methicillin-Resistant Staphylococcus aureus Using Rifampin and Fluoroquinolone Combinations Open
Staphylococcus aureus biofilms complicate the treatment of device-related infections. We hypothesized that combining rifampin with fluoroquinolones could eradicate biofilms even in antimicrobial-resistant S. aureus strains. We determined t…
View article: P-2315. Clinical outcome of rifabutin-based treatment for pulmonary tuberculosis in solid organ transplant recipients
P-2315. Clinical outcome of rifabutin-based treatment for pulmonary tuberculosis in solid organ transplant recipients Open
Background Rifabutin (Rfb) is commonly administered instead of rifampicin for the treatment of tuberculosis (TB) in SOTR to avoid substantial drug interaction of rifampin. However, evidence of its efficacy is scarce. Methods We conducted a…
View article: P-927. Clinical Outcome of Ampicillin plus Ceftriaxone Compared to Nafcillin or Cefazolin plus Gentamicin as an Empirical Treatment for Infective Endocarditis
P-927. Clinical Outcome of Ampicillin plus Ceftriaxone Compared to Nafcillin or Cefazolin plus Gentamicin as an Empirical Treatment for Infective Endocarditis Open
Background A combination of anti-staphylococcal penicillin or cefazolin and gentamicin has been recommended as an empirical treatment regimen for native valve or late prosthetic valve infective endocarditis (NV/LPVIE), while the recent Eur…
View article: Environmental Mold Management in Negative‐Pressure Isolation Wards During the COVID‐19 Pandemic: A Potential Indicator of COVID‐19‐Associated Pulmonary Aspergillosis
Environmental Mold Management in Negative‐Pressure Isolation Wards During the COVID‐19 Pandemic: A Potential Indicator of COVID‐19‐Associated Pulmonary Aspergillosis Open
High concentration of mold spores in inhaled air is an important risk factor for invasive mold infections. COVID‐19 (coronavirus disease 2019)‐associated pulmonary aspergillosis (CAPA) is a serious complication of severe COVID‐19. To inves…
View article: Patients With Mild COVID-19 Exhibit Low Functional Avidity of SARS-CoV-2 Membrane Protein-Reactive CD4<sup>+</sup> T Cells
Patients With Mild COVID-19 Exhibit Low Functional Avidity of SARS-CoV-2 Membrane Protein-Reactive CD4<sup>+</sup> T Cells Open
Herein, we found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-unexposed individuals exhibited an increased frequency of CD4+ T cells against SARS-CoV-2 membrane (M) protein, suggesting that SARS-CoV-2 M-reac…
View article: Clinical and microbiological analyses of colistin-resistant strains among carbapenem-resistant <i>Enterobacter cloacae</i> complex clinical isolates
Clinical and microbiological analyses of colistin-resistant strains among carbapenem-resistant <i>Enterobacter cloacae</i> complex clinical isolates Open
Carbapenem-resistant Enterobacter cloacae complex (CR-ECC), which is rapidly increasing as the cause of nosocomial infections, has limited treatment options. The aim of this study is to investigate the microbiological and clinical traits a…
View article: Rapid Recovery From SARS-CoV-2 Infection Among Immunocompromised Children Despite Limited Neutralizing Antibody Response: A Virologic and Sero-Immunologic Analysis of a Single-Center Cohort
Rapid Recovery From SARS-CoV-2 Infection Among Immunocompromised Children Despite Limited Neutralizing Antibody Response: A Virologic and Sero-Immunologic Analysis of a Single-Center Cohort Open
IC pediatric patients rapidly recovered from COVID-19 with low viral loads. Antibody response was limited, but cytokine analysis suggested an enhanced IFN-γ- and IL-18-mediated immune response without excessive activation of inflammatory c…
View article: Characteristics and Prevalence of Sequelae after COVID-19: A Longitudinal Cohort Study
Characteristics and Prevalence of Sequelae after COVID-19: A Longitudinal Cohort Study Open
Many patients still showed long COVID after 18 months post SARS-CoV-2 infection. When managing these patients, the assessment of multiple aspects is necessary.
View article: Overcoming the age-dependent SARS-CoV-2 vaccine response through hybrid immunity: analysis of humoral and cellular immunity with mass cytometry profiling
Overcoming the age-dependent SARS-CoV-2 vaccine response through hybrid immunity: analysis of humoral and cellular immunity with mass cytometry profiling Open
View article: Longitudinal multiomic profiling and corticosteroid modulation of the immediate innate immune response to an adenovirus-vector vaccine
Longitudinal multiomic profiling and corticosteroid modulation of the immediate innate immune response to an adenovirus-vector vaccine Open
Among new vaccine technologies contributed to the control of the COVID-19 pandemic, ChAdOx1 nCoV-19, a chimpanzee adenovirus (ChAd)-vector vaccine expressing the SARS-CoV-2 spike protein, could be administered globally owing to its low pro…
View article: Wet-spinning of reduced graphene oxide composite fiber by mechanical synergistic effect with graphene scrolling method
Wet-spinning of reduced graphene oxide composite fiber by mechanical synergistic effect with graphene scrolling method Open
Carbon-based fibers have attracted attention in various field owing to their exceptional properties, including high tensile strength, thermal stability, and electrical conductivity. In particular, graphene-based high-strength fibers are pr…
View article: Antimicrobial activity of ceftazidime-avibactam against KPC-2-producing Enterobacterales: a cross-combination and dose-escalation titration study with relebactam and vaborbactam
Antimicrobial activity of ceftazidime-avibactam against KPC-2-producing Enterobacterales: a cross-combination and dose-escalation titration study with relebactam and vaborbactam Open
With the introduction of ceftazidime-avibactam worldwide, the antimicrobial activity of new β-lactam/β-lactamase inhibitors (BL/BLIs) needs to be investigated. From January 2020 to June 2023, Klebsiella pneumoniae carbapenemase (KPC)-produ…
View article: GaussianTalker: Real-Time High-Fidelity Talking Head Synthesis with Audio-Driven 3D Gaussian Splatting
GaussianTalker: Real-Time High-Fidelity Talking Head Synthesis with Audio-Driven 3D Gaussian Splatting Open
We propose GaussianTalker, a novel framework for real-time generation of pose-controllable talking heads. It leverages the fast rendering capabilities of 3D Gaussian Splatting (3DGS) while addressing the challenges of directly controlling …
View article: Talk3D: High-Fidelity Talking Portrait Synthesis via Personalized 3D Generative Prior
Talk3D: High-Fidelity Talking Portrait Synthesis via Personalized 3D Generative Prior Open
Recent methods for audio-driven talking head synthesis often optimize neural radiance fields (NeRF) on a monocular talking portrait video, leveraging its capability to render high-fidelity and 3D-consistent novel-view frames. However, they…
View article: Extensively drug-resistant Enterobacter ludwigii co-harbouring MCR-9 and a multicopy of blaIMP-1 in South Korea
Extensively drug-resistant Enterobacter ludwigii co-harbouring MCR-9 and a multicopy of blaIMP-1 in South Korea Open
In this study, we describe an Enterobacter ludwigii clinical isolate that is resistant to both carbapenems and colistin in South Korea. Antimicrobial susceptibility testing revealed that E. ludwigii CRE2104-31 was non-susceptible to all te…
View article: 449. Elevated Lactate Dehydrogenase in Convalescent Severe COVID-19 Patients Reflects Delayed Clinical Recovery and Activated Th1 and Th17 Responses
449. Elevated Lactate Dehydrogenase in Convalescent Severe COVID-19 Patients Reflects Delayed Clinical Recovery and Activated Th1 and Th17 Responses Open
Background Elevated lactate dehydrogenase (LD) levels during acute phase of COVID-19 is known to reflect multiple organ injuries and clinical severity. However, clinical implication and origin of elevated LD after convalescence have not be…
View article: 1106. Comparison of Diagnostic Power of Conventional Culture and Automated Blood Culture System with Pleural Fluid
1106. Comparison of Diagnostic Power of Conventional Culture and Automated Blood Culture System with Pleural Fluid Open
Background Microbiological diagnosis of empyema is often hindered by low sensitivity of conventional culture. Automated blood culture system has been reported to enhance diagnostic power for culture of non-blood specimens. The purpose of t…
View article: 212. Effectiveness of Empirical Piperacillin/tazobactam Compared to Cefepime for Bloodstream Infection Caused by Gram-Negative Bacilli
212. Effectiveness of Empirical Piperacillin/tazobactam Compared to Cefepime for Bloodstream Infection Caused by Gram-Negative Bacilli Open
Background Piperacillin/tazobactam (PTZ) and cefepime (CFP) are commonly used antibiotics for healthcare-associated infections and immunocompromised patients. However, few studies have compared the clinical effectiveness of these two antib…
View article: False-positive <i>Aspergillus</i> galactomannan immunoassay in the glucose component of total parenteral nutrition products
False-positive <i>Aspergillus</i> galactomannan immunoassay in the glucose component of total parenteral nutrition products Open
In October 2022, we experienced a significant increase in samples showing high galactomannan (GM) indexes ranging from 6.22 to 10.58, as determined by the Platelia Aspergillus antigen immunoassay, also known as the GM test. After reviewing…
View article: Longitudinal kinetics of neutralizing antibodies against circulating SARS-CoV-2 variants and estimated level of group immunity of booster-vaccinated individuals during omicron-dominated COVID-19 outbreaks in the Republic of Korea, 2022
Longitudinal kinetics of neutralizing antibodies against circulating SARS-CoV-2 variants and estimated level of group immunity of booster-vaccinated individuals during omicron-dominated COVID-19 outbreaks in the Republic of Korea, 2022 Open
The coronavirus disease 2019 pandemic persisted for 3 years and is now transitioning to endemicity. We illustrated the change in group immunity induced by vaccination (monovalent vaccines) and breakthrough infections (BIs) in a healthcare …
View article: Immune Response Kinetics Following a Third Heterologous BNT162b2 Booster Dose After Primary 2-Dose ChAdOx1 Vaccination in Relation to Omicron Breakthrough Infection: A Prospective Nationwide Cohort Study in South Korea
Immune Response Kinetics Following a Third Heterologous BNT162b2 Booster Dose After Primary 2-Dose ChAdOx1 Vaccination in Relation to Omicron Breakthrough Infection: A Prospective Nationwide Cohort Study in South Korea Open
Background Immune responses to each vaccine must be investigated to establish effective vaccination strategies for the ongoing coronavirus disease (COVID-19) pandemic. We investigated the long-term kinetics of immune responses after hetero…
View article: Effectiveness of regdanvimab treatment for SARS-CoV-2 delta variant, which exhibited decreased in vitro activity: a nationwide real-world multicenter cohort study
Effectiveness of regdanvimab treatment for SARS-CoV-2 delta variant, which exhibited decreased in vitro activity: a nationwide real-world multicenter cohort study Open
Background Immune-evading severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are emerging continuously. The clinical effectiveness of monoclonal antibody agents that exhibit decreased in vitro activity against SARS-CoV-2…
View article: Impact of vancomycin resistance in Enterococcus faecium bloodstream infection on mortality: A retrospective analysis of nationwide surveillance data
Impact of vancomycin resistance in Enterococcus faecium bloodstream infection on mortality: A retrospective analysis of nationwide surveillance data Open
In patients with Efm BSI, vancomycin resistance was independently associated with mortality.