Jaejoon Lim
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View article: PATH-71. Survival analysis of adult diffuse midline gliomas and the clinical significance of H3K27 alteration
PATH-71. Survival analysis of adult diffuse midline gliomas and the clinical significance of H3K27 alteration Open
OBJECTIVE Although pediatric midline-located gliomas (MGs) with H3K27 alteration have been widely known to have a poor prognosis, few researchers have assessed adult MGs with H3K27 alteration. We aimed to determine the effect of H3K27 alte…
View article: Combined Treatment with Evogliptin and Temozolomide Alters miRNA Expression but Shows Limited Additive Effect on Glioma
Combined Treatment with Evogliptin and Temozolomide Alters miRNA Expression but Shows Limited Additive Effect on Glioma Open
Dipeptidyl-peptidase IV (DPP4) inhibitors have shown potential anti-tumor properties. This study investigates the therapeutic potential of evogliptin, a DPP4 inhibitor, both as a single agent and in combination with temozolomide (TMZ), in …
View article: The immunological landscape of traumatic brain injury: insights from pathophysiology to experimental models
The immunological landscape of traumatic brain injury: insights from pathophysiology to experimental models Open
Traumatic brain injury (TBI) is a complex, heterogeneous neuropathological disease that continues to be among the prominent causes of mortality and disability around the world. Translational success in TBI has been significant, yet therapi…
View article: Endoscopic pre-subtemporal keyhole approach: Anatomical feasibility and clinical applications [SevEN-016]
Endoscopic pre-subtemporal keyhole approach: Anatomical feasibility and clinical applications [SevEN-016] Open
View article: Pathological phenotypes of astrocytes in Alzheimer’s disease
Pathological phenotypes of astrocytes in Alzheimer’s disease Open
Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and…
View article: The Inflammatory Characteristics of Symptomatic Glioma Associated With Poor Prognosis and Chemoresistance via Tumor Necrosis Factor Signaling Pathway
The Inflammatory Characteristics of Symptomatic Glioma Associated With Poor Prognosis and Chemoresistance via Tumor Necrosis Factor Signaling Pathway Open
The findings suggest that symptomatic glioma enhances inflammatory responses linked to poor prognosis and chemoresistance. This supports the hypothesis that immediate treatment of incidental glioma may improve patient outcomes over a wait-…
View article: DDDR-20. FOSL1 INDUCES TMZ-CHEMORESISTANCE IN GLIOBLASTOMA VIA REGULATION OF IL-6-STAT3TYR705PATHWAY-MEDIATED STEMNESS
DDDR-20. FOSL1 INDUCES TMZ-CHEMORESISTANCE IN GLIOBLASTOMA VIA REGULATION OF IL-6-STAT3TYR705PATHWAY-MEDIATED STEMNESS Open
Glioblastoma (GBM) is the most lethal brain tumors with intensive resistance to drug. Although glioblastoma has been tried to treat with diverse strategies, drug resistance is still concerning. Finding new therapeutic targets to improve co…
View article: PATH-16. SURVIVAL ANALYSIS OF ADULT MIDLINE-LOCATED GLIOMAS: DOES THE H3K27 ALTERATION IN ADULT MIDLINE-LOCATED GLIOMAS ACTUALLY INDICATE A POOR PROGNOSIS?
PATH-16. SURVIVAL ANALYSIS OF ADULT MIDLINE-LOCATED GLIOMAS: DOES THE H3K27 ALTERATION IN ADULT MIDLINE-LOCATED GLIOMAS ACTUALLY INDICATE A POOR PROGNOSIS? Open
OBJECTIVE Although pediatric midline-located gliomas (MGs) with H3K27 alteration have been widely known to have a poor prognosis, few researchers have assessed adult MGs with H3K27 alteration. We aimed to determine the effect of H3K27 alte…
View article: CTNI-30. MESENCHYMAL STEM CELL (MSC11FCD) BASED THERAPY ELICITED A FAVORABLE RESPONSE WITH EFFICIENT 5-FU CONVERSION IN PATIENTS WITH RECURRENT GLIOBLASTOMA: AN OPEN LABEL, PHASE I/IIA TRIAL
CTNI-30. MESENCHYMAL STEM CELL (MSC11FCD) BASED THERAPY ELICITED A FAVORABLE RESPONSE WITH EFFICIENT 5-FU CONVERSION IN PATIENTS WITH RECURRENT GLIOBLASTOMA: AN OPEN LABEL, PHASE I/IIA TRIAL Open
Mesenchymal stem cells (MSC) are being developed as therapeutic agents for treatment of various diseases due to their high tropism to damaged sites and cancers, and low immunogenicity. We are developing technologies to efficiently transfer…
View article: Dysregulation of inflammasome activation in glioma
Dysregulation of inflammasome activation in glioma Open
View article: TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer’s diseases
TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer’s diseases Open
Neuroinflammation and oxidative stress have been implicated in the pathogenesis of Alzheimer's disease (AD). Neuroinflammation and oxidative stress are associated with neuronal death in AD. Astrocytes are linked to neuroinflammation during…
View article: Predictive biomarkers for the responsiveness of recurrent glioblastomas to activated killer cell immunotherapy
Predictive biomarkers for the responsiveness of recurrent glioblastomas to activated killer cell immunotherapy Open
View article: Comparing the Expression of Canonical and Non-Canonical Inflammasomes Across Glioma Grades: Evaluating Their Potential as an Aggressiveness Marker
Comparing the Expression of Canonical and Non-Canonical Inflammasomes Across Glioma Grades: Evaluating Their Potential as an Aggressiveness Marker Open
This study identified the potential of non-canonical inflammasomes as aggressiveness markers for gliomas and presented a perspective for improving glioma treatment.
View article: PATH-06. SURVIVAL ANALYSIS FOR ADULT MIDLINE GLIOMA: DO ADULT MIDLINE GLIOMAS WITH THE H3 K27M MUTATION REALLY HAVE POOR PROGNOSIS?
PATH-06. SURVIVAL ANALYSIS FOR ADULT MIDLINE GLIOMA: DO ADULT MIDLINE GLIOMAS WITH THE H3 K27M MUTATION REALLY HAVE POOR PROGNOSIS? Open
PURPOSE Since it is known that midline located glioma with H3K27 mutation in children has a disastrous prognosis, in 2016 WHO classification, these tumors were defined as diffuse midline glioma (DMG) and classified as grade IV. A lot of pa…
View article: TMIC-11. ASSOCIATION OF TIM-3/GAL-9 AXIS WITHNLRC4 INFLAMMASOME IN GLIOMA MALIGNANCY: TIM-3/GAL-9 INDUCE THE NLRC4 INFLAMMASOME
TMIC-11. ASSOCIATION OF TIM-3/GAL-9 AXIS WITHNLRC4 INFLAMMASOME IN GLIOMA MALIGNANCY: TIM-3/GAL-9 INDUCE THE NLRC4 INFLAMMASOME Open
Tim-3/Gal-9 and the NLRC4 inflammasome contribute to glioma progression. However, the underlying mechanisms involved are unclear. Here, we observed that Tim-3/Gal-9 expression increased with glioma malignancy and found that Tim-3/Gal-9 reg…
View article: EPCO-09. TRANSCRIPTOMIC LANDSCAPE OF LOWER GRADE GLIOMA BASED ON AGE-RELATED NON-SILENT SOMATIC MUTATIONS
EPCO-09. TRANSCRIPTOMIC LANDSCAPE OF LOWER GRADE GLIOMA BASED ON AGE-RELATED NON-SILENT SOMATIC MUTATIONS Open
Glioma accounts for 80% of all malignant brain tumours and is the most common adult primary brain tumour. Age is an important factor affecting the development of cancer, as somatic mutations accumulate with age. Here, we aimed to analyse t…
View article: TMET-17. NOX2-INDUCED HIGH GLYCOLYTIC ACTIVITY CONTRIBUTES TO THE GAIN OF COL5A1-MEDIATED MESENCHYMAL PHENOTYPE IN GBM
TMET-17. NOX2-INDUCED HIGH GLYCOLYTIC ACTIVITY CONTRIBUTES TO THE GAIN OF COL5A1-MEDIATED MESENCHYMAL PHENOTYPE IN GBM Open
Glioblastoma multiforme (GBM) is the most aggressive type of glioma and exhibits extensive heterogeneity and poor prognosis with a high recurrence rate. Among the genetic alterations in GBM with different phenotypic states, a mesenchymal s…
View article: Predictive Biomarkers for the Responsiveness of Recurrent Glioblastomas to Activated Killer Cell Immunotherapy
Predictive Biomarkers for the Responsiveness of Recurrent Glioblastomas to Activated Killer Cell Immunotherapy Open
Background Recurrent glioblastoma multiforme (GBM) is a highly aggressive primary malignant brain tumor that is resistant to existing treatments. Recently, we reported that activated autologous natural killer (NK) cell therapeutics induced…
View article: Endoscopic transorbital extradural anterior clinoidectomy: A stepwise surgical technique and case series study [SevEN-013]
Endoscopic transorbital extradural anterior clinoidectomy: A stepwise surgical technique and case series study [SevEN-013] Open
Background Anterior clinoidectomy is an important procedure for approaching the central skull base lesions. However, anterior clinoidectomy through the endoscopic transorbital approach (ETOA) still has limitations due to technical difficul…
View article: Survival analysis of adult midline-located gliomas: Does the H3K27 alteration in adult midline- located gliomas actually indicate a poor prognosis?
Survival analysis of adult midline-located gliomas: Does the H3K27 alteration in adult midline- located gliomas actually indicate a poor prognosis? Open
Purpose Although pediatric diffuse midline gliomas (DMGs) have been studied extensively, and midline-located gliomas (MGs) with H3K27 alterations in children have been shown to have a poor prognosis, few researchers have assessed adult DMG…
View article: Potential of Hematologic Parameters in Predicting Mortality of Patients with Traumatic Brain Injury
Potential of Hematologic Parameters in Predicting Mortality of Patients with Traumatic Brain Injury Open
Traumatic brain injury (TBI) occurs frequently, and acute TBI requiring surgical treatment is closely related to patient survival. Models for predicting the prognosis of patients with TBI do not consider various factors of patient status; …
View article: Pedicled frontal periosteal rescue flap via eyebrow incision for skull base reconstruction (SevEN-002)
Pedicled frontal periosteal rescue flap via eyebrow incision for skull base reconstruction (SevEN-002) Open
View article: Intracranial aspergillosis in immunocompetent adult patients without risk factors: a systematic review
Intracranial aspergillosis in immunocompetent adult patients without risk factors: a systematic review Open
View article: Association of Tim-3/Gal-9 Axis with NLRC4 Inflammasome in Glioma Malignancy: Tim-3/Gal-9 Induce the NLRC4 Inflammasome
Association of Tim-3/Gal-9 Axis with NLRC4 Inflammasome in Glioma Malignancy: Tim-3/Gal-9 Induce the NLRC4 Inflammasome Open
Tim-3/Gal-9 and the NLRC4 inflammasome contribute to glioma progression. However, the underlying mechanisms involved are unclear. Here, we observed that Tim-3/Gal-9 expression increased with glioma malignancy and found that Tim-3/Gal-9 reg…
View article: NOX2-Induced High Glycolytic Activity Contributes to the Gain of COL5A1-Mediated Mesenchymal Phenotype in GBM
NOX2-Induced High Glycolytic Activity Contributes to the Gain of COL5A1-Mediated Mesenchymal Phenotype in GBM Open
The alteration of the cellular metabolism is a hallmark of glioma. The high glycolytic phenotype is a critical factor in the pathogenesis of high-grade glioma, including glioblastoma multiforme (GBM). GBM has been stratified into three sub…
View article: Transcriptomic landscape of lower grade glioma based on age-related non-silent somatic mutations
Transcriptomic landscape of lower grade glioma based on age-related non-silent somatic mutations Open
View article: CeRNA network analysis representing characteristics of different tumor environments based on 1p/19q codeletion in oligodendrogliomas
CeRNA network analysis representing characteristics of different tumor environments based on 1p/19q codeletion in oligodendrogliomas Open
View article: NOX2-induced high glycolytic activity promotes heterogeneity by pro-fibrotic phenotype in high-grade glioma
NOX2-induced high glycolytic activity promotes heterogeneity by pro-fibrotic phenotype in high-grade glioma Open
View article: Predictive biomarkers for the responsiveness to autologous activated killer cell immunotherapy in recurrent Glioblastomas
Predictive biomarkers for the responsiveness to autologous activated killer cell immunotherapy in recurrent Glioblastomas Open
View article: Autologous adoptive immune-cell therapy elicited a durable response with enhanced immune reaction signatures in patients with recurrent glioblastoma: a phase I/IIa trial
Autologous adoptive immune-cell therapy elicited a durable response with enhanced immune reaction signatures in patients with recurrent glioblastoma: a phase I/IIa trial Open