Jae‐Jun Shim
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View article: Switching to besifovir in patients with chronic hepatitis B receiving tenofovir disoproxil fumarate: A randomized trial
Switching to besifovir in patients with chronic hepatitis B receiving tenofovir disoproxil fumarate: A randomized trial Open
Background/Aims: Besifovir (BSV) showed comparable antiviral activity and superior safety profiles to tenofovir disoproxil fumarate (TDF) in treatment-naïve chronic hepatitis B (CHB). However, no data are available regarding the antiviral …
View article: Pretreatment gamma‐glutamyl transferase predicts mortality in patients with chronic hepatitis B treated with nucleotide/nucleoside analogs
Pretreatment gamma‐glutamyl transferase predicts mortality in patients with chronic hepatitis B treated with nucleotide/nucleoside analogs Open
Elevated serum gamma‐glutamyl transferase (GGT) levels are associated with chronic hepatitis B (CHB)‐related hepatocellular carcinoma. However, their role in predicting mortality in patients with CHB treated with nucleotide/nucleoside anal…
View article: miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration
miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration Open
Immunotherapies have emerged as promising strategies for cancer treatment. However, existing immunotherapies have poor activity in high-grade serous ovarian cancer (HGSC) due to the immunosuppressive tumor microenvironment and the associat…
View article: Comorbidities and the use of comedications among patients with chronic hepatitis C in Korea: A nationwide cross-sectional study
Comorbidities and the use of comedications among patients with chronic hepatitis C in Korea: A nationwide cross-sectional study Open
Background/Aims: Chronic hepatitis C (CHC) is the second leading cause of liver-related mortality and is more prevalent in the elderly population in Korea. Decisions to initiate treatment and selection of proper antiviral agents may be cha…
View article: Data from Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer
Data from Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer Open
Hepatocellular carcinoma (HCC) is a heterogeneous disease. Mouse models are commonly used as preclinical models to study hepatocarcinogenesis, but how well these models recapitulate molecular subtypes of human HCC is unclear. Here, integra…
View article: Data from Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer
Data from Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer Open
Hepatocellular carcinoma (HCC) is a heterogeneous disease. Mouse models are commonly used as preclinical models to study hepatocarcinogenesis, but how well these models recapitulate molecular subtypes of human HCC is unclear. Here, integra…
View article: Supplemental Data from Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer
Supplemental Data from Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer Open
S1. Correlation of prognostic probability and risk scores for mouse HCCs. S2. Glycolytic gene expression signature in mouse liver. S3. Glycolytic expression signature in mouse HCC tumors from 9 models. S4. Correlation of hepatic stem cell …
View article: Supplemental Data from Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer
Supplemental Data from Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer Open
S1. Correlation of prognostic probability and risk scores for mouse HCCs. S2. Glycolytic gene expression signature in mouse liver. S3. Glycolytic expression signature in mouse HCC tumors from 9 models. S4. Correlation of hepatic stem cell …
View article: Data from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Data from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Purpose: This study was aimed at developing and validating a quantitative multigene assay for predicting tumor recurrence after gastric cancer surgery.Experimental Design: Gene expression data were generated from tumor tissue…
View article: Supplementary Methods from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Supplementary Methods from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Methods
View article: Data from Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project
Data from Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project Open
Purpose: The Cancer Genome Atlas (TCGA) project recently uncovered four molecular subtypes of gastric cancer: Epstein–Barr virus (EBV), microsatellite instability (MSI), genomically stable (GS), and chromosomal instability (CIN). Ho…
View article: Figure S7 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S7 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
dot plots
View article: Figure S9 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S9 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Clinical significance of RRS in validation cohort.
View article: Supplementary Information, Supplementary References, Supplementary Figures 1-2, Supplementary Tables 1-10 from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma
Supplementary Information, Supplementary References, Supplementary Figures 1-2, Supplementary Tables 1-10 from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma Open
Figure S1: Significant concordance between silence of Hippo signature and YAP1 expression in human hepatocellular carcinoma (HCC); Figure S2: Venn diagram of gene lists from two different gene expression signatures; Table S1: Genes in the …
View article: Figure S8 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S8 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
ROC curves showing the predictive accuracy for recurrence.
View article: Table S3 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Table S3 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Univariate and Multivariate Cox Regression Analyses of Recurrence Free Survival Durations of Patients in the Validation Cohort.
View article: Table S3 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Table S3 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Univariate and Multivariate Cox Regression Analyses of Recurrence Free Survival Durations of Patients in the Validation Cohort.
View article: Table S2 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Table S2 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Genes used in development of the recurrence risk score assay.
View article: Figure S1 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S1 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Expression of YAP1 in gastric cancer cells.
View article: Figure S8 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S8 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
ROC curves showing the predictive accuracy for recurrence.
View article: Figure S2 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S2 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
YAP1 signature and selection of candidate genes
View article: Figure S4 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S4 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Hierarchical clustering analysis of YAP1 signature in 5 GC cell lines.
View article: Data from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma
Data from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma Open
Purpose: The Hippo pathway is a tumor suppressor in the liver. However, the clinical significance of Hippo pathway inactivation in HCC is not clearly defined. We analyzed genomic data from human and mouse tissues to determine clinic…
View article: Figure S5 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S5 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Selection of candidate genes for quantitative reverse transcription (qRT) PCR experiments. GO, Gene Ontology database.
View article: Supplementary Methods from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Supplementary Methods from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Methods
View article: Figure S2 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S2 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
YAP1 signature and selection of candidate genes
View article: Table S1 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Table S1 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Distribution of candidate genes in biological process categories of the Gene Ontology database.
View article: Figure S4 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S4 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Hierarchical clustering analysis of YAP1 signature in 5 GC cell lines.
View article: Figure S6 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S6 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
Recurrence risk score and its clinical significance.
View article: Figure S7 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Figure S7 from Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer Open
dot plots