JaeSang Ko
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View article: A Nationwide Survey by the Korean Society of Ophthalmic Plastic and Reconstructive Surgery (KSOPRS) on the Management of Thyroid Eye Disease in South Korea
A Nationwide Survey by the Korean Society of Ophthalmic Plastic and Reconstructive Surgery (KSOPRS) on the Management of Thyroid Eye Disease in South Korea Open
Purpose: To evaluate current diagnostic and therapeutic practices among South Korean oculoplastic surgeons, with particular focus on adherence to guidelines and perspectives on emerging therapies such as teprotumumab.Methods: A nationwide,…
View article: Nucleus YAP expression as a prognostic biomarker for local recurrence in eyelid sebaceous carcinoma
Nucleus YAP expression as a prognostic biomarker for local recurrence in eyelid sebaceous carcinoma Open
View article: AI-based assessment of Clinical Activity Score and detection of active thyroid eye disease using facial images: validation of Glandy CAS
AI-based assessment of Clinical Activity Score and detection of active thyroid eye disease using facial images: validation of Glandy CAS Open
Purpose The Clinical Activity Score (CAS) is widely used to assess thyroid eye disease (TED) activity but can vary based on the evaluator’s expertise. We developed and externally validated Glandy CAS, a machine learning (ML)-assisted syste…
View article: Immunoglobulin G4–Related Ophthalmic Disease
Immunoglobulin G4–Related Ophthalmic Disease Open
View article: Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves’ Orbitopathy
Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves’ Orbitopathy Open
Our results demonstrate that NNMT was associated with the inflammatory mechanisms of GO. Inhibiting NNMT, either through mRNA silencing or pharmacologic antagonism, markedly reduced pro-inflammatory reactions. These findings suggest that t…
View article: Role of SerpinA3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts
Role of SerpinA3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts Open
Silencing SerpinA3 attenuated the expression of proinflammatory mediators, adipogenic differentiation, and hyaluronan production. Our results indicate that SerpinA3 plays a significant role in GO and may serve as a novel therapeutic target.
View article: Deep Learning−Driven Exophthalmometry through Facial Photographs in Thyroid Eye Disease
Deep Learning−Driven Exophthalmometry through Facial Photographs in Thyroid Eye Disease Open
View article: Effect of an 8-week lumbar stabilization and lower extremity strength exercise on lumbar pain and physical function in middle-aged women with chronic back pain
Effect of an 8-week lumbar stabilization and lower extremity strength exercise on lumbar pain and physical function in middle-aged women with chronic back pain Open
[Purpose] We hypothesized that an 8-week combined exercise program that includes lumbar stabilization and lower extremity strength exercises would be more effective than lumbar stabilization exercises alone in improving muscle stiffness, v…
View article: Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts
Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts Open
LOXL3 is crucial in GO pathogenesis. LOXL3 inhibition reduced inflammatory cytokine production, fibrotic protein expression, and fibroblast differentiation into adipocytes. This study highlights LOXL3 as a potential therapeutic target for …
View article: Therapeutic role of histone deacetylase inhibition in an <i>in vitro</i> model of Graves' orbitopathy
Therapeutic role of histone deacetylase inhibition in an <i>in vitro</i> model of Graves' orbitopathy Open
Graves' orbitopathy (GO), a manifestation of Graves' disease, is characterized by orbital fibroblast‑induced inflammation, leading to fibrosis or adipogenesis. Histone deacetylase (HDAC) serves a central role in autoimmune diseases and fib…
View article: Role of Inositol-Requiring Enzyme 1 and Autophagy in the Pro-Fibrotic Mechanism Underlying Graves’ Orbitopathy
Role of Inositol-Requiring Enzyme 1 and Autophagy in the Pro-Fibrotic Mechanism Underlying Graves’ Orbitopathy Open
IRE1 mediates autophagy and the pro-fibrotic mechanism of GO, which provides a more comprehensive interpretation of GO pathogenesis and suggests potential therapeutic targets.
View article: Phospholipase C-γ as a Potential Therapeutic Target for Graves’ Orbitopathy
Phospholipase C-γ as a Potential Therapeutic Target for Graves’ Orbitopathy Open
Background: Phospholipase C-γ (PLC-γ) plays a crucial role in immune responses and is related to the pathogenesis of various inflammatory disorders. In this study, we investigated the role of PLC-γ and the therapeutic effect of the PLC-spe…
View article: The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves’ Orbitopathy
The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves’ Orbitopathy Open
Adipsin, secreted by orbital fibroblasts, may play a distinct role in the pathogenesis of GO. Inhibition of adipsin ameliorated the production of pro-inflammatory cytokines and adipogenesis in orbital fibroblasts. Our study provides an in …
View article: Kimura Disease with Lacrimal Sac and Nasolacrimal Duct Involvement: A Case Report
Kimura Disease with Lacrimal Sac and Nasolacrimal Duct Involvement: A Case Report Open
Kimura disease (KD) is a rare allergic or autoimmune chronic inflammatory disease of the soft tissue in the head and neck region.Painless subcutaneous masses are pre-
View article: Sarcopenia as a potential risk factor for senile blepharoptosis: Nationwide Surveys (KNHANES 2008–2011)
Sarcopenia as a potential risk factor for senile blepharoptosis: Nationwide Surveys (KNHANES 2008–2011) Open
As the world’s population is aging, sarcopenia is recognized as essential to assess people’s lifelong condition and do appropriate early intervention. Senile blepharoptosis is also a problem in old age deteriorating visual function and cau…
View article: Therapeutic effect of ibrutinib, a selective Bruton’s tyrosine kinase inhibitor, in orbital fibroblasts from patients with Graves’ orbitopathy
Therapeutic effect of ibrutinib, a selective Bruton’s tyrosine kinase inhibitor, in orbital fibroblasts from patients with Graves’ orbitopathy Open
Purpose Bruton’s tyrosine kinase (BTK) is an essential protein in B-cell antigen receptor (BCR) signaling pathway and is known to be related to pathogenetic effect on B-cell related malignancies and various autoimmune diseases. In this stu…
View article: Endoscopic transorbital approach to the cavernous sinus: Cadaveric anatomy study and clinical application (‡SevEN-009)
Endoscopic transorbital approach to the cavernous sinus: Cadaveric anatomy study and clinical application (‡SevEN-009) Open
Objective Cavernous sinus (CS) invasion is frequently encountered in the management of skull base tumors. Surgical treatment of tumors in the CS is technically demanding, and selection of an optimal surgical approach is critical for maxima…
View article: Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves’ Orbitopathy
Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves’ Orbitopathy Open
BMP7 transcript levels were downregulated in Graves' orbital tissues. Exogenous BMP7 treatment showed inhibitory effects on the production of profibrotic proteins and proinflammatory cytokines in orbital fibroblasts. Our results provide a …
View article: Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease
Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease Open
Objectives The clinical course of thyroid eye disease (TED) is heterogeneous and predicting patients who may develop the severe sequelae of the disease is difficult. In this study, we evaluated the longitudinal association between changes …
View article: Quantitative assessment of increase in orbital volume after orbital floor fracture reconstruction using a bioabsorbable implant
Quantitative assessment of increase in orbital volume after orbital floor fracture reconstruction using a bioabsorbable implant Open
View article: Serum Selenium Levels in Patients with Graves Disease: Associations with Clinical Activity and Severity in a Retrospective Case-control Study
Serum Selenium Levels in Patients with Graves Disease: Associations with Clinical Activity and Severity in a Retrospective Case-control Study Open
Purpose: To compare serum selenium levels in Graves patients and non-Graves control participants and to evaluate associations between serum selenium levels and clinical features of Graves orbitopathy (GO).Methods: We conducted a single-cen…
View article: Signal transducer and activator of transcription 3 as a potential therapeutic target for Graves’ orbitopathy
Signal transducer and activator of transcription 3 as a potential therapeutic target for Graves’ orbitopathy Open
View article: The underestimated incidence of an orbital angioleiomyoma is possibly associated with an orbital cavernous hemangioma: illustrative case
The underestimated incidence of an orbital angioleiomyoma is possibly associated with an orbital cavernous hemangioma: illustrative case Open
BACKGROUND Orbital angioleiomyoma is generally considered a rare tumor; approximately 40 cases have been reported. However, after their experience with 6 consecutive cases in their single institution during 3 years, the authors speculate t…
View article: A Case of Complication After Conjoint Fascial Sheath Suspension
A Case of Complication After Conjoint Fascial Sheath Suspension Open
Kim, Bo ram M.D.; Ko, Jae sang M.D., Ph.D.; Yoon, Jin Sook M.D., Ph.D. Author Information
View article: PERK mediates oxidative stress and adipogenesis in Graves’ orbitopathy pathogenesis
PERK mediates oxidative stress and adipogenesis in Graves’ orbitopathy pathogenesis Open
We examined endoplasmic reticulum (ER) stress-related gene expression in orbital tissues from patients with Graves’ orbitopathy (GO) and the effects of silencing protein kinase RNA-like endoplasmic reticulum kinase (PERK) in primary orbita…
View article: Role of Proprotein Convertase Subtilisin/Kexin Type 9 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts
Role of Proprotein Convertase Subtilisin/Kexin Type 9 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts Open
Background The proprotein convertase subtilisin/kexin type 9 (PCSK9) has been implicated in the pathogenesis of inflammatory diseases. We sought to investigate the role of PCSK9 in the pathogenesis of Graves’ orbitopathy (GO) and whether i…
View article: A Pilot Clinical Study of Ocular Prosthesis Fabricated by Three-dimensional Printing and Sublimation Technique
A Pilot Clinical Study of Ocular Prosthesis Fabricated by Three-dimensional Printing and Sublimation Technique Open
Our study confirms the biologic and physiochemical safety of 3D-printed ocular prostheses created using computer-aided design technology and a sublimation technique. The patients' questionnaires and the judgment of the ophthalmologists/ocu…
View article: Protein tyrosine phosphatase 1B as a therapeutic target for Graves’ orbitopathy in an in vitro model
Protein tyrosine phosphatase 1B as a therapeutic target for Graves’ orbitopathy in an in vitro model Open
Graves' orbitopathy (GO) is characterised in early stages by orbital fibroblast inflammation, which can be aggravated by oxidative stress and often leads to fibrosis. Protein tyrosine protein 1B (PTP1B) is a regulator of inflammation and a…
View article: A Rare Complication of a Large Emphysema after Orbital Wall Fracture Surgery with Silastic Sheet Implant
A Rare Complication of a Large Emphysema after Orbital Wall Fracture Surgery with Silastic Sheet Implant Open
View article: Leptomeningeal Seeding in Choroidal Melanoma after Enucleation Surgery
Leptomeningeal Seeding in Choroidal Melanoma after Enucleation Surgery Open