Jae-Sook Ahn
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View article: Novel Wearable-Based Real-Time Temperature Monitoring in Hospitals for Febrile Adverse Events in Patients with Cancer: A Prospective Feasibility Study
Novel Wearable-Based Real-Time Temperature Monitoring in Hospitals for Febrile Adverse Events in Patients with Cancer: A Prospective Feasibility Study Open
Cancer remains a leading cause of mortality worldwide. Chemotherapy is effective but can cause febrile neutropenia, deplete neutrophils, and increase infection risk. Although timely fever detection is critical to prevent complications, per…
View article: Prognostic Factors for Relapse and the Role of Maintenance Therapy in Acute Promyelocytic Leukemia: A Real-World Multicenter Study in Korea
Prognostic Factors for Relapse and the Role of Maintenance Therapy in Acute Promyelocytic Leukemia: A Real-World Multicenter Study in Korea Open
These findings highlight prognostic factors for relapse and the importance of individualized therapeutic strategies for high-risk patients. Moreover, our findings indicate that post-consolidation MRD is the most significant predictor of re…
View article: Blood-based Epigenetic Instability Linked to Human Aging and Disease
Blood-based Epigenetic Instability Linked to Human Aging and Disease Open
The abundance, dynamics, and context-dependent heterogeneity of DNA methylation - where a pattern considered abnormal in one cell type may be normal in another - poses challenges in identifying methylation abnormalities linked to disease r…
View article: Clinical Usefulness of Sequential Circulating-Tumor DNA Analysis in Patients with Advanced Stage Diffuse Large B-Cell Lymphoma Treated with R-CHOP Immunochemotherapy
Clinical Usefulness of Sequential Circulating-Tumor DNA Analysis in Patients with Advanced Stage Diffuse Large B-Cell Lymphoma Treated with R-CHOP Immunochemotherapy Open
Background Circulating-tumor DNA (ctDNA) has emerged as an innovative approach to analyze the genetic information in various malignancies. Previous studies reported that pretreatment ctDNA level and molecular response during treatment were…
View article: Clonal hematopoiesis in the donor does not adversely affect long-term outcomes following allogeneic hematopoietic stem cell transplantation: result from a 13-year follow-up
Clonal hematopoiesis in the donor does not adversely affect long-term outcomes following allogeneic hematopoietic stem cell transplantation: result from a 13-year follow-up Open
Donor clonal hematopoiesis may be transferred to the recipient through allogeneic hematopoietic stem cell transplantation (HSCT), but the potential for adverse long-term impact on transplant outcomes remains unknown. A total of 744 samples…
View article: <i>FLT3</i> mutations in acute myeloid leukemia: a review focusing on clinically applicable drugs
<i>FLT3</i> mutations in acute myeloid leukemia: a review focusing on clinically applicable drugs Open
FMS-like tyrosine kinase 3 (FLT3) mutations, the most frequently detected genetic aberrations in patients with acute myeloid leukemia (AML), are identified in approximately 30% of patients with newly diagnosed AML and are more common in pa…
View article: <i>TET2</i> mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes
<i>TET2</i> mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes Open
Decrease in DNA dioxygenase activity generated by TET2 gene family is crucial in myelodysplastic syndromes (MDS). The general downregulation of 5-hydroxymethylcytosine (5-hmC) argues for a role of DNA demethylation in MDS beyond TET2 mutat…
View article: RNA sequencing as an alternative tool for detecting measurable residual disease in core-binding factor acute myeloid leukemia
RNA sequencing as an alternative tool for detecting measurable residual disease in core-binding factor acute myeloid leukemia Open
DNA sequencing-based measurable residual disease (MRD) detection has shown to be clinically relevant in AML. However, the same methodology cannot be applied to fusion gene-driven subtypes of AML such as core-binding factor AML (CBF-AML). H…
View article: Next-generation sequencing–based posttransplant monitoring of acute myeloid leukemia identifies patients at high risk of relapse
Next-generation sequencing–based posttransplant monitoring of acute myeloid leukemia identifies patients at high risk of relapse Open
Key Points Higher allelic burden at day 21 of post-HCT is associated with higher risk of relapse and mortality. Longitudinal tracking of AML patients receiving HCT is feasible and provides clinically relevant information.
View article: Spectrum of somatic mutation dynamics in chronic myeloid leukemia following tyrosine kinase inhibitor therapy
Spectrum of somatic mutation dynamics in chronic myeloid leukemia following tyrosine kinase inhibitor therapy Open
Key Points Mutation clearance in CML does not directly result in successful treatment in CML. Clinical implications of patterns of mutation acquisition, persistence, and clearance in CML should be interpreted with caution.
View article: Allogeneic Stem Cell Transplantation Outcomes in Acute Myeloid Leukemia Patients with t(8;21)(q22;q22) in First Remission According to Conditioning Regimen
Allogeneic Stem Cell Transplantation Outcomes in Acute Myeloid Leukemia Patients with t(8;21)(q22;q22) in First Remission According to Conditioning Regimen Open
Acute myeloid leukemia (AML) with t(8;21)(q22;q22) is associated with favorable prognosis. This subtype of AML is not recommended allogeneic stem cell transplantation (alloSCT) as post-remission therapy due to a higher transplant-related m…