Jaeuk Sim
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View article: Formal [4+2] combined ionic and radical approach of vinylogus enaminonitriles for highly substituted sulfonyl pyridazines
Formal [4+2] combined ionic and radical approach of vinylogus enaminonitriles for highly substituted sulfonyl pyridazines Open
A formal [4 + 2] reaction for the synthesis of 5’-sulfonyl-4’-aryl-3-cyano substituted pyridazine compounds from the reaction between vinylogus enaminonitrile and sulfonyl hydrazides is reported. The key features of our pyridazine synthesi…
View article: Microwave-Mediated, Catalyst-Free Synthesis of 1,2,4-Triazolo[1,5-a]pyridines from Enaminonitriles
Microwave-Mediated, Catalyst-Free Synthesis of 1,2,4-Triazolo[1,5-a]pyridines from Enaminonitriles Open
A catalyst-free, additive-free, and eco-friendly method for synthesizing 1,2,4-triazolo[1,5-a]pyridines under microwave conditions has been established. This tandem reaction involves the use of enaminonitriles and benzohydrazides, a transa…
View article: CCDC 2022420: Experimental Crystal Structure Determination
CCDC 2022420: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2022523: Experimental Crystal Structure Determination
CCDC 2022523: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Inhibitory Effect of Chlorogenic Acid Analogues Comprising Pyridine and Pyrimidine on α-MSH-Stimulated Melanogenesis and Stability of Acyl Analogues in Methanol
Inhibitory Effect of Chlorogenic Acid Analogues Comprising Pyridine and Pyrimidine on α-MSH-Stimulated Melanogenesis and Stability of Acyl Analogues in Methanol Open
In continuation of studies for α-MSH stimulated melanogenesis inhibitors, we have evaluated the design, synthesis, and activity of a new series of chlorogenic acid (CGA) analogues comprising pyridine, pyrimidine, and diacyl derivatives. Am…
View article: Regiodivergent Organocatalytic Reactions
Regiodivergent Organocatalytic Reactions Open
Organocatalysts are abundantly used for various transformations, particularly to obtain highly enantio- and diastereomeric pure products by controlling the stereochemistry. These applications of organocatalysts have been the topic of sever…
View article: α-Hydroxy acid as an aldehyde surrogate: metal-free synthesis of pyrrolo[1,2-<i>a</i>]quinoxalines, quinazolinones, and other N-heterocycles<i>via</i>decarboxylative oxidative annulation reaction
α-Hydroxy acid as an aldehyde surrogate: metal-free synthesis of pyrrolo[1,2-<i>a</i>]quinoxalines, quinazolinones, and other N-heterocycles<i>via</i>decarboxylative oxidative annulation reaction Open
A TBHP mediated, metal-free approach for the synthesis of quinoxalines, quinazolinones, and indolo quinoxaline was developed from alpha hydroxy acidsviadecarboxylation followed by condensation.
View article: Front Cover Picture: <i>γ</i>‐Functionalization of <i>α,β</i>‐Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4‐Aryl‐2‐Bromopyridines (Adv. Synth. Catal. 23/2019)
Front Cover Picture: <i>γ</i>‐Functionalization of <i>α,β</i>‐Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4‐Aryl‐2‐Bromopyridines (Adv. Synth. Catal. 23/2019) Open
The front cover picture, designed by Jaeuk Sim from the group of Heesoon Lee and Jae-Kyung Jung, illustrates the synthesis of 4-aryl-2-halopyridines via γ-functionalization of α,β-unsaturated nitriles. Our method features enamine formation…
View article: CCDC 1860056: Experimental Crystal Structure Determination
CCDC 1860056: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …