Jae‐Woo Kwon
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View article: Asthma Remission and Its Predictors in Severe Asthma: Real-World Study from the Korean Severe Asthma Registry
Asthma Remission and Its Predictors in Severe Asthma: Real-World Study from the Korean Severe Asthma Registry Open
Background Remission has emerged as a therapeutic goal in asthma, but most studies in severe asthma have focused on biologic-treated patients in controlled settings. Real-world data from Asian populations are scarce. We aimed to evaluate t…
View article: Oral Corticosteroid Prescription Trends in South Korea: A 10-Year Nationwide Population-Based Study Using the NHIS-NSC
Oral Corticosteroid Prescription Trends in South Korea: A 10-Year Nationwide Population-Based Study Using the NHIS-NSC Open
Objectives To investigate long-term trends in oral corticosteroid (OCS) prescribing among the adult population in South Korea and to evaluate variations in prescribing patterns across diagnoses, healthcare institution types, and clinical s…
View article: Unbalanced Associations between Physical, Psychological, and Social Domains of the Leicester Cough Questionnaire: Network and Mediation Analyses
Unbalanced Associations between Physical, Psychological, and Social Domains of the Leicester Cough Questionnaire: Network and Mediation Analyses Open
Background: The Leicester Cough Questionnaire (LCQ) is a validated instrument for evaluating cough-related impairments within three domains: physical, psychological, and social. This study investigated how the physical, psychological, and …
View article: Alterations in Gut Microbiota Composition Are Related to Disease Severity and Systemic Inflammation in Patients With Chronic Urticaria
Alterations in Gut Microbiota Composition Are Related to Disease Severity and Systemic Inflammation in Patients With Chronic Urticaria Open
View article: Biomarkers of type 2 inflammation as predictors of response to biologics for severe eosinophilic asthma
Biomarkers of type 2 inflammation as predictors of response to biologics for severe eosinophilic asthma Open
Background The relationship between pre-treatment levels of blood eosinophil count (BEC), fractional exhaled nitric oxide ( F ENO ) and sputum eosinophils (Sp-EOS) and treatment response to monoclonal antibodies (mAbs) in severe eosinophil…
View article: Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma
Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma Open
View article: Impact of Biologics on Nasal Symptoms in Severe Asthmatics: Findings From the PRISM Study
Impact of Biologics on Nasal Symptoms in Severe Asthmatics: Findings From the PRISM Study Open
Dupilumab demonstrates a significant improvement not only in total SNOT-22 scores but also in the extranasal rhinological, physiologic, and sleep dysfunction domain scores compared to conventional or anti-IL-5 treatment in patients with se…
View article: Rosacea and Its Potential Role in the Development of Irritable Bowel Syndrome: Insights From the Korean National Health Insurance Service-National Sample Cohort
Rosacea and Its Potential Role in the Development of Irritable Bowel Syndrome: Insights From the Korean National Health Insurance Service-National Sample Cohort Open
The findings support the hypothesis that rosacea may be associated with an increased risk of IBS, potentially mediated by systemic inflammatory pathways and neurological interactions as suggested by the gut-skin axis. This indicates that g…
View article: Real-World Effectiveness and Safety of Mepolizumab in Severe Eosinophilic Asthma: Insights From the Korean Severe Asthma Registry (KoSAR)
Real-World Effectiveness and Safety of Mepolizumab in Severe Eosinophilic Asthma: Insights From the Korean Severe Asthma Registry (KoSAR) Open
Mepolizumab, an interleukin-5 antagonist, is globally recognized for its efficacy in randomized controlled trials for the treatment of severe eosinophilic asthma. The present study explored its real-world effectiveness and safety in a Kore…
View article: Prevalence and Clinical Characteristics of Severe Asthma With Fungal Sensitization in Korea
Prevalence and Clinical Characteristics of Severe Asthma With Fungal Sensitization in Korea Open
The prevalence of fungal sensitization in severe asthma is approximately twice as high as in non-severe asthma. Early diagnosed asthma may be a risk factor for SAFS, and patients with SAFS face a greater burden of additional treatment comp…
View article: Longitudinal multi-trajectory phenotypes of severe eosinophilic asthma on type 2 biologics treatment
Longitudinal multi-trajectory phenotypes of severe eosinophilic asthma on type 2 biologics treatment Open
To optimally monitor treatment response in SEA patients on type 2 biologics, integrating longitudinal biomarker features is essential.
View article: Multiple Allergen Simultaneous Test for Food Allergens Cannot Screen Wheat-Dependent, Exercise-Induced Anaphylaxis and α-Gal Syndrome
Multiple Allergen Simultaneous Test for Food Allergens Cannot Screen Wheat-Dependent, Exercise-Induced Anaphylaxis and α-Gal Syndrome Open
Screening tests for specific immunoglobulin E (sIgE) to food allergens, such as the multiple allergen simultaneous test (MAST), are widely used in patients with suspected food allergies in South Korea. We evaluated whether MAST could effec…
View article: Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study
Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study Open
View article: A Comparative Study of Deep Learning for Monitoring Motor Behavior in Older Adults
A Comparative Study of Deep Learning for Monitoring Motor Behavior in Older Adults Open
Elderly people need to strengthen their muscle strength and improve their balance ability to prevent falls and chronic diseases. In this study, we modified the existing image classification-based model and performed regression analysis to …
View article: Real-World Effectiveness of Biologics in Patients With Severe Asthma: Analysis of the KoSAR
Real-World Effectiveness of Biologics in Patients With Severe Asthma: Analysis of the KoSAR Open
Biologics are highly effective in Korean patients with Type 2 severe asthma, significantly reducing acute exacerbation rates and doses of oral corticosteroids, while also improving lung function. Therefore, it seems beneficial to administe…
View article: Sex-related disparities in cough-associated symptoms across different age groups
Sex-related disparities in cough-associated symptoms across different age groups Open
Background: Sex-related disparities in the prevalence of chronic cough have been consistently reported globally, with varying male-to-female ratios. Objectives: This study aimed to evaluate sex-related differences by comparing correlations…
View article: Incidence of New Asthma in Pregnancy and Associated Risk Factors: A 10-Year Nationwide Population-Based Study
Incidence of New Asthma in Pregnancy and Associated Risk Factors: A 10-Year Nationwide Population-Based Study Open
Pregnancy is a risk factor for asthma exacerbation and may trigger new-onset asthma in nonasthmatics. This study evaluated the epidemiology of newly diagnosed asthma during pregnancy and the associated risk factors among previously nonasth…
View article: Clinical Characteristics of T2-Low and T2-High Asthma-Chronic Obstructive Pulmonary Disease Overlap: Findings From COREA Cohort
Clinical Characteristics of T2-Low and T2-High Asthma-Chronic Obstructive Pulmonary Disease Overlap: Findings From COREA Cohort Open
Since ACOs with T2-high profiles may have lower lung function and more frequent exacerbations, T2-high specific therapies, such as biologics, should be actively considered in T2-high ACO patients.
View article: Characteristics of Severe Asthma in the Elderly: Observations From the Korean Severe Asthma Registry (KoSAR)
Characteristics of Severe Asthma in the Elderly: Observations From the Korean Severe Asthma Registry (KoSAR) Open
SA in the elderly is characterized by lower lung function, less type 2-low airway inflammation, and comorbidity with COPD. These findings are being taken into consideration in the management of elderly patients with SA in real-world clinic…
View article: A comparison of treatment response to biologics in asthma-COPD overlap and pure asthma: Findings from the PRISM study
A comparison of treatment response to biologics in asthma-COPD overlap and pure asthma: Findings from the PRISM study Open
View article: Corrigendum to "Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice"
Corrigendum to "Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice" Open
Youngheon Park, Jimin Jang, Jooyeon Lee, Hyosin Baek, Jaehyun Park, Sang-Ryul Cha, Se Bi Lee, Sunghun Na, Jae-Woo Kwon, Young Jun Park, Myeong Jun Choi, Kye-Seong Kim, Seok-Ho Hong, Se-Ran Yang. IJSC 2023;16:448-9. https://doi.org/10.15283…
View article: A smartphone-based application for cough counting in patients with acute asthma exacerbation
A smartphone-based application for cough counting in patients with acute asthma exacerbation Open
The strong correlation between cough counts using the AI-based algorithm and human experts, and other indicators of patient health status provides evidence of the validity of this AI algorithm for use in asthma patients experiencing an acu…
View article: Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice
Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice Open
Taken together, these data suggest that cP1P treatment enhances hdMSC migration in regulation of Hippo signaling and MSCcP1P provide a therapeutic potential for ALI/ARDS treatment.
View article: An artificial intelligence algorithm‐based smartphone application for daily cough monitoring
An artificial intelligence algorithm‐based smartphone application for daily cough monitoring Open
Data S1 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the a…
View article: Association Between Acid-Suppressive Drugs and Risk of Rosacea: Retrospective Study Using the Korean National Health Insurance Service-National Sample Cohort
Association Between Acid-Suppressive Drugs and Risk of Rosacea: Retrospective Study Using the Korean National Health Insurance Service-National Sample Cohort Open
Results from our study indicate that H2RA or PPI is associated with the occurrence of rosacea among patients with GI diseases in the Korean population. The risk was increased in dose-dependent manner, even after adjusting for confounding v…
View article: Multiple allergen simultaneous test is useful in assessing allergen sensitization and its geographic variations by the Geographic Information System-based approach
Multiple allergen simultaneous test is useful in assessing allergen sensitization and its geographic variations by the Geographic Information System-based approach Open
View article: Unmet Needs of Patients With Chronic Urticaria: A Survey in Korea
Unmet Needs of Patients With Chronic Urticaria: A Survey in Korea Open
Chronic urticaria (CU) is a common problem with a high disease burden that has a significant negative impact on quality of life. Many patients are undertreated, and awareness of management strategies is low among clinicians. The present st…
View article: Clinical predictors of treatment response to tiotropium add-on therapy in adult asthmatic patients: From multicenter real-world cohort data in Korea
Clinical predictors of treatment response to tiotropium add-on therapy in adult asthmatic patients: From multicenter real-world cohort data in Korea Open
The results of this study suggest that tiotropium add-on for uncontrolled asthma with ICS-LABA would be more effective in patients with positive BDR or ACO. Additionally, an increase in FEV1 following tiotropium may predict a lower risk of…
View article: Measurement and Interpretation of Fractional Exhaled Nitric Oxide
Measurement and Interpretation of Fractional Exhaled Nitric Oxide Open
Nitric oxide is produced by the human lungs and increases in response to type 2 inflammation. The level of fractional exhaled nitric oxide (FeNO) may reflect type 2 inflammation in the airways, which is related to eosinophilic inflammation…
View article: Circulating IL-32 and IL-33 levels in patients with asthma and COPD: a retrospective cross-sectional study
Circulating IL-32 and IL-33 levels in patients with asthma and COPD: a retrospective cross-sectional study Open