Jahangheer Shaik
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View article: LB1237 Quantifying exosomes and characterizing their tetraspanin expression in platelet-poor plasma, platelet-rich plasma and following platelet activation
LB1237 Quantifying exosomes and characterizing their tetraspanin expression in platelet-poor plasma, platelet-rich plasma and following platelet activation Open
View article: Comparative genomics of Giardia duodenalis sub-assemblage AI beaver (Be-2) and human (WB-C6) strains show remarkable homozygosity, sequence similarity, and conservation of VSP genes
Comparative genomics of Giardia duodenalis sub-assemblage AI beaver (Be-2) and human (WB-C6) strains show remarkable homozygosity, sequence similarity, and conservation of VSP genes Open
View article: The FLRT3-UNC5B Pathway is a Novel Regulator of T Immunosurveillance
The FLRT3-UNC5B Pathway is a Novel Regulator of T Immunosurveillance Open
Our understanding of molecular cell-surface interactions that control T cell responses in cancer remains limited despite many advances in the field. We hypothesized that tumor cells take advantage of developmental protein-protein interacti…
View article: Comparative Genomics of Giardia duodenalis Sub-assemblage A1 Beaver (Be-2) and Human (WB-C6) Strains Show Remarkable Homozygosity, Sequence Similarity, and Conservation of VSP Genes
Comparative Genomics of Giardia duodenalis Sub-assemblage A1 Beaver (Be-2) and Human (WB-C6) Strains Show Remarkable Homozygosity, Sequence Similarity, and Conservation of VSP Genes Open
Giardia duodenalis , a major cause of waterborne infection, infects a wide range of mammalian hosts and is subdivided into eight genetically well-defined assemblages named A through H. However, fragmented genomes and a lack of comparative …
View article: The FLRT3-UNC5B checkpoint pathway inhibits T cell–based cancer immunotherapies
The FLRT3-UNC5B checkpoint pathway inhibits T cell–based cancer immunotherapies Open
Cancers exploit coinhibitory receptors on T cells to escape tumor immunity, and targeting such mechanisms has shown remarkable clinical benefit, but in a limited subset of patients. We hypothesized that cancer cells mimic noncanonical mech…
View article: Self-Hybridization in Leishmania major
Self-Hybridization in Leishmania major Open
Leishmania are parasitic protozoa that cause a wide spectrum of diseases collectively known as the leishmaniases. Sexual reproduction in Leishmania has been proposed as an important source of genetic diversity and has been formally demonst…
View article: 748 A phase 1/2, open-label, dose-escalation, safety and tolerability study of NC762 in subjects with advanced or metastatic solid tumors
748 A phase 1/2, open-label, dose-escalation, safety and tolerability study of NC762 in subjects with advanced or metastatic solid tumors Open
Background NC762 is a humanized IgG1κ monoclonal antibody that targets human B7-H4 (B7 homolog 4), a transmembrane protein, associated with the B7 family of molecules known for their immunomodulatory functions. While limited expression is …
View article: 490 Clinical benefit through Siglec-15 targeting with NC318 antibody in subjects with Siglec-15 positive advanced solid tumors
490 Clinical benefit through Siglec-15 targeting with NC318 antibody in subjects with Siglec-15 positive advanced solid tumors Open
Background Siglec-15 (S15) is a member of the Siglec family of immunoglobulin superfamily proteins involved in immune regulation. NC318 is a first-in-class humanized IgG1κ monoclonal antibody that blocks S15-mediated immune suppression. Me…
View article: 487 NC410, a fusion protein of LAIR-2 (Leukocyte Associated Immunoglobulin-like Receptor) with human IgG1 Fc, is safe & tolerable with evidence of immune modulation in subjects with advanced solid tumors
487 NC410, a fusion protein of LAIR-2 (Leukocyte Associated Immunoglobulin-like Receptor) with human IgG1 Fc, is safe & tolerable with evidence of immune modulation in subjects with advanced solid tumors Open
Background Collagen and C1q in the extracellular matrix (ECM), are the predominant ligands for LAIR-1, an inhibitory receptor expressed on the cell surface of several immune cell subsets that inhibits immune activation and migration. LAIR-…
View article: Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction
Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction Open
Collagens are a primary component of the extracellular matrix and are functional ligands for the inhibitory immune receptor leukocyte-associated immunoglobulin-like receptor (LAIR)-1. LAIR-2 is a secreted protein that can act as a decoy re…
View article: Author response: Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction
Author response: Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction Open
View article: Leishmania Sexual Reproductive Strategies as Resolved through Computational Methods Designed for Aneuploid Genomes
Leishmania Sexual Reproductive Strategies as Resolved through Computational Methods Designed for Aneuploid Genomes Open
A cryptic sexual reproductive cycle in Leishmania has been inferred through population genetic studies revealing the presence of hybrid genotypes in natural isolates, with attempts made to decipher sexual strategies by studying complex chr…
View article: Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway
Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway Open
We have previously shown that the microfilarial (mf) stage of Brugia malayi can inhibit the mammalian target of rapamycin (mTOR; a conserved serine/threonine kinase critical for immune regulation and cellular growth) in human dendritic cel…
View article: Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction
Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction Open
Collagens are a primary component of the extracellular matrix and are functional ligands for the inhibitory immune receptor leukocyte associated immunoglobulin-like receptor-1 (LAIR-1). Leukocyte associated immunoglobulin-like receptor-2 (…
View article: In Vitro Generation of Leishmania Hybrids
In Vitro Generation of Leishmania Hybrids Open
Protozoan parasites in the genus Leishmania produce a broad spectrum of diseases in their human hosts. The strain and species-specific genes controlling these diverse clinical outcomes have remained poorly tractable using reverse genetics …
View article: Correction for Khan et al., Global selective sweep of a highly inbred genome of the cattle parasite <i>Neospora caninum</i>
Correction for Khan et al., Global selective sweep of a highly inbred genome of the cattle parasite <i>Neospora caninum</i> Open
The authors note three author names appeared incorrectly. The author name Sarah M. Latham should instead appear as Sophia M. Latham, the author name Elizabeth A. Innes should instead appear as Elisabeth A. Innes, and the author name Johnat…
View article: Global selective sweep of a highly inbred genome of the cattle parasite<i>Neospora caninum</i>
Global selective sweep of a highly inbred genome of the cattle parasite<i>Neospora caninum</i> Open
Neospora caninum , a cyst-forming apicomplexan parasite, is a leading cause of neuromuscular diseases in dogs as well as fetal abortion in cattle worldwide. The importance of the domestic and sylvatic life cycles of Neospora , and the role…
View article: Neosporosis: An Overview of Its Molecular Epidemiology and Pathogenesis
Neosporosis: An Overview of Its Molecular Epidemiology and Pathogenesis Open
Neospora caninum (N. caninum), a cyst-forming protozoan parasite, is a major cause of bovine abortions and neonatal mortality worldwide. N. caninum has a broad intermediate host range, and its sexual cycle occurs exclusively in canids. Ano…
View article: Disseminated Metacestode <i>Versteria</i> Species Infection in Woman, Pennsylvania, USA1
Disseminated Metacestode <i>Versteria</i> Species Infection in Woman, Pennsylvania, USA1 Open
A patient in Pennsylvania, USA, with common variable immunodeficiency sought care for fever, cough, and abdominal pain. Imaging revealed lesions involving multiple organs. Liver resection demonstrated necrotizing granulomas, recognizable t…
View article: Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania
Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania Open
Hybrid genotypes have been repeatedly described among natural isolates of Leishmania, and the recovery of experimental hybrids from sand flies co-infected with different strains or species of Leishmania has formally demonstrated that membe…
View article: Population Structure of <i>Leishmania</i> using POPSICLE reveals extensive dichotomy in zygosity and discloses the role of sex in diversity of the parasite
Population Structure of <i>Leishmania</i> using POPSICLE reveals extensive dichotomy in zygosity and discloses the role of sex in diversity of the parasite Open
Mosaic aneuploidy prevalent in organisms such as Leishmania and Fungi and in genomes of some neurological disorders and cancers manifest as non-integer haplotypes due to heterogeneity in somy across a population of cells. Thus, the tools d…
View article: POPSICLE: A Software Suite to Study Population Structure and Ancestral Determinants of Phenotypes using Whole Genome Sequencing Data
POPSICLE: A Software Suite to Study Population Structure and Ancestral Determinants of Phenotypes using Whole Genome Sequencing Data Open
The advent of new sequencing technologies has provided access to genome-wide markers which may be evaluated for their association with phenotypes. Recent studies have leveraged these technologies and sequenced hundreds and sometimes thousa…
View article: Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair Open
View article: White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection
White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection Open
View article: Tilting the balance between RNA interference and replication eradicates<i>Leishmania</i>RNA virus 1 and mitigates the inflammatory response
Tilting the balance between RNA interference and replication eradicates<i>Leishmania</i>RNA virus 1 and mitigates the inflammatory response Open
Significance Leishmania parasites can be infected with Leishmaniavirus (LRV1), a double-stranded RNA virus whose presence in Leishmania guyanensis parasites exacerbates disease severity in both mouse models and humans. Studies of the role …
View article: REDHORSE-REcombination and Double crossover detection in Haploid Organisms using next-geneRation SEquencing data
REDHORSE-REcombination and Double crossover detection in Haploid Organisms using next-geneRation SEquencing data Open
REDHORSE is an efficient analytical pipeline that serves as a bridge between genomic alignments and existing recombination detection algorithms. Moreover, REDHORSE is equipped with a recombination detection algorithm specifically designed …