Jaime Tomko
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View article: Protecting simian immunodeficiency virus-infected macaques from Mycobacterium tuberculosis by intravenous Bacillus Calmette-Guérin vaccination requires viral control 2308
Protecting simian immunodeficiency virus-infected macaques from Mycobacterium tuberculosis by intravenous Bacillus Calmette-Guérin vaccination requires viral control 2308 Open
Description Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a major global health challenge, especially for people living with HIV (PLWH) not on antiretroviral therapy (ART). We previously showed that intravenous Bacillus…
View article: GEODE: an in silico tool that translates in vitro to in vivo predictions of tuberculosis antibiotic combination efficacy
GEODE: an in silico tool that translates in vitro to in vivo predictions of tuberculosis antibiotic combination efficacy Open
Introduction Tuberculosis (TB) remains the primary cause of death due to infectious disease in the world. TB, while treatable, requires an extended course of multiple antibiotics, taking 6–9 months, and many antibiotic regimens have delete…
View article: Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques
Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques Open
Co-infection with both HIV and M. tuberculosis (Mtb) results in disseminated tuberculosis (TB) and accelerated progression of HIV. Despite greater access to antiretroviral treatment (ART), it remains unclear whether suppression of HIV repl…
View article: Intravenous BCG-mediated protection against tuberculosis requires CD4+ T cells and CD8α+ lymphocytes
Intravenous BCG-mediated protection against tuberculosis requires CD4+ T cells and CD8α+ lymphocytes Open
Tuberculosis (TB) is a major health burden worldwide despite widespread intradermal (ID) BCG vaccination in newborns. We previously demonstrated that changing the BCG route and dose from 5 × 105 CFUs ID to 5 × 107 CFUs i.v. resulted in pre…
View article: Intravenous Bacillus Calmette–Guérin (BCG) Induces a More Potent Airway and Lung Immune Response than Intradermal BCG in Simian Immunodeficiency Virus–infected Macaques
Intravenous Bacillus Calmette–Guérin (BCG) Induces a More Potent Airway and Lung Immune Response than Intradermal BCG in Simian Immunodeficiency Virus–infected Macaques Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the leading causes of death due to an infectious agent. Coinfection with HIV exacerbates M. tuberculosis infection outcomes in people living with HIV. Bacillus Calmette–Gué…
View article: Intravenous BCG induces a more potent airway and lung immune response than intradermal BCG in SIV-infected macaques<sup>1</sup>
Intravenous BCG induces a more potent airway and lung immune response than intradermal BCG in SIV-infected macaques<sup>1</sup> Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the leading causes of death due to an infectious agent. Coinfection with HIV exacerbates Mtb infection outcomes in people living with HIV (PLWH). Bacillus Calmette-Gu…
View article: CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques
CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques Open
Tuberculosis (TB) is a major cause of morbidity and mortality worldwide despite widespread intradermal (ID) BCG vaccination in newborns. We previously demonstrated that changing the route and dose of BCG vaccination from 5ξ10 5 CFU ID to 5…
View article: Markov Field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques
Markov Field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques Open
Summary Analysis of multi-modal datasets can identify multi-scale interactions underlying biological systems, but can be beset by spurious connections due to indirect impacts propagating through an unmapped biological network. For example,…
View article: A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: protection of African green monkeys from COVID-19 disease
A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: protection of African green monkeys from COVID-19 disease Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and is responsible for the largest human pandemic in 100 years. Thirty-four vaccines are currently approved for use worldwide, and approximately 67% of…
View article: CD4<sup>+</sup>T cells are homeostatic regulators during<i>Mtb</i>reinfection
CD4<sup>+</sup>T cells are homeostatic regulators during<i>Mtb</i>reinfection Open
Immunological priming – either in the context of prior infection or vaccination – elicits protective responses against subsequent Mycobacterium tuberculosis ( Mtb ) infection. However, the changes that occur in the lung cellular milieu pos…
View article: CD8+ lymphocytes are critical for early control of tuberculosis in macaques
CD8+ lymphocytes are critical for early control of tuberculosis in macaques Open
The functional role of CD8+ lymphocytes in tuberculosis remains poorly understood. We depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all CD8α+ cells (using anti-CD8α antibody) significantly impaired ea…
View article: Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens
Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens Open
Tuberculosis (TB) continues to be one of the deadliest infectious diseases in the world, causing ~1.5 million deaths every year. The World Health Organization initiated an End TB Strategy that aims to reduce TB-related deaths in 2035 by 95…
View article: Distributable, Metabolic PET Reporting of Tuberculosis
Distributable, Metabolic PET Reporting of Tuberculosis Open
Tuberculosis remains a large global disease burden for which treatment regimens are protracted and monitoring of disease activity difficult. Existing detection methods rely almost exclusively on bacterial culture from sputum which limits s…
View article: Characterizing the Spectrum of Latent<i>Mycobacterium tuberculosis</i>in the Cynomolgus Macaque Model: Clinical, Immunologic, and Imaging Features of Evolution
Characterizing the Spectrum of Latent<i>Mycobacterium tuberculosis</i>in the Cynomolgus Macaque Model: Clinical, Immunologic, and Imaging Features of Evolution Open
Mycobacterium tuberculosis infection outcomes have been described as active tuberculosis or latent infection but a spectrum of outcomes is now recognized. We used a nonhuman primate model, which recapitulates human infection, to characteri…
View article: Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens
Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens Open
Tuberculosis (TB) continues to be one of the deadliest infectious diseases in the world, causing ~1.5 million deaths every year. The World Health Organization initiated an End TB Strategy that aims to reduce TB-related deaths in 2035 by 95…
View article: T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques
T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques Open
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB. Immunologic investigation of lung granulomas is essential for understanding host…
View article: Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control Open
Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of …
View article: T cell transcription factor expression evolves as adaptive immunity matures in granulomas from<i>Mycobacterium tuberculosis</i>-infected cynomolgus macaques
T cell transcription factor expression evolves as adaptive immunity matures in granulomas from<i>Mycobacterium tuberculosis</i>-infected cynomolgus macaques Open
SUMMARY Mycobacterium tuberculosis ( Mtb) , the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB. Immunologic investigation of lung granulomas is essential for understa…
View article: Retention of <sup>64</sup>Cu-FLFLF, a Formyl Peptide Receptor 1-Specific PET Probe, Correlates with Macrophage and Neutrophil Abundance in Lung Granulomas from Cynomolgus Macaques
Retention of <sup>64</sup>Cu-FLFLF, a Formyl Peptide Receptor 1-Specific PET Probe, Correlates with Macrophage and Neutrophil Abundance in Lung Granulomas from Cynomolgus Macaques Open
Neutrophilic inflammation correlates with severe tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (Mtb). Granulomas are lesions that form in TB, and a PET probe for following neutrophil recruitment to granulomas could pred…