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View article: Long-term outcomes of benznidazole treatment in chronic Chagas disease: A 27-year cohort study of parasitological cure and death in the Jequitinhonha Valley, Brazil
Long-term outcomes of benznidazole treatment in chronic Chagas disease: A 27-year cohort study of parasitological cure and death in the Jequitinhonha Valley, Brazil Open
Background Chagas disease (CD) is a neglected tropical infection prevalent in rural areas of Latin America. The etiological treatment is indicated for patients with both acute and chronic phases of CD, except in the most advanced clinical …
View article: Genetic markers of thrombophilia as predictors of outcome in colorectal cancer
Genetic markers of thrombophilia as predictors of outcome in colorectal cancer Open
Colorectal cancer (CRC) is the second leading cause of malignancy-related death worldwide, representing a significant health concern. Understanding the disease pathogenesis and identifying potential prognostic biomarkers is critical for im…
View article: Assessment of competencies of clinical research professionals and proposals to improve clinical research in Portugal
Assessment of competencies of clinical research professionals and proposals to improve clinical research in Portugal Open
Background Clinical studies are coordinated by multidisciplinary teams, which often lack adequate training and competencies. In this study, ROCHE and AICIB (Agency for Clinical Research and Biomedical Innovation) conducted a self-assessmen…
View article: Urinary Catheter Causing Paracentesis-induced Circulatory Dysfunction
Urinary Catheter Causing Paracentesis-induced Circulatory Dysfunction Open
Case Presentation: A 78-year-old male was admitted to the hospital due to acute-on-chronic liver failure with spontaneous bacterial peritonitis. About six liters of a yellow, turbid fluid were collected via indwelling urinary catheter (UC)…
View article: Plasma microRNA Environment Linked to Tissue Factor Pathway and Cancer-Associated Thrombosis: Prognostic Significance in Ovarian Cancer
Plasma microRNA Environment Linked to Tissue Factor Pathway and Cancer-Associated Thrombosis: Prognostic Significance in Ovarian Cancer Open
Ovarian cancer (OC) is a leading cause of death among gynaecological malignancies. The haemostatic system, which controls blood flow and prevents clotting disorders, paradoxically drives OC progression while increasing the risk of venous t…
View article: Haemostatic Gene Expression in Cancer-Related Immunothrombosis: Contribution for Venous Thromboembolism and Ovarian Tumour Behaviour
Haemostatic Gene Expression in Cancer-Related Immunothrombosis: Contribution for Venous Thromboembolism and Ovarian Tumour Behaviour Open
Ovarian cancer (OC) is the deadliest gynaecological malignancy. Identifying new prognostic biomarkers is an important research field. Haemostatic components together with leukocytes can drive cancer progression while increasing the suscept…
View article: Pioneering the implementation of a precision oncology strategy in Portugal: the Precision Oncology Platform trial
Pioneering the implementation of a precision oncology strategy in Portugal: the Precision Oncology Platform trial Open
Background and purpose: The Precision Oncology Platform (POP) trial represents the effort of the Portuguese Oncology Institute of Porto (IPO Porto) for joining other leading European institutions in both ‘Personalised Cancer Medicine for a…
View article: Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements
Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements Open
Ovarian cancer (OC) is the female genital malignancy with the highest lethality. Patients present a poor prognosis mainly due to the late clinical presentation allied with the common acquisition of chemoresistance and a high rate of tumour…
View article: Long Non-Coding RNAs: Bridging Cancer-Associated Thrombosis and Clinical Outcome of Ovarian Cancer Patients
Long Non-Coding RNAs: Bridging Cancer-Associated Thrombosis and Clinical Outcome of Ovarian Cancer Patients Open
Ovarian cancer (OC) and venous thromboembolism (VTE) have a close relationship, in which tumour cells surpass the haemostatic system to drive cancer progression. Long non-coding RNAs (lncRNAs) have been implicated in VTE pathogenesis, yet …
View article: Venous thromboembolism-related genetic determinant F11 rs4253417 is a potential prognostic factor in ischaemic stroke
Venous thromboembolism-related genetic determinant F11 rs4253417 is a potential prognostic factor in ischaemic stroke Open
Ischaemic stroke (IS) and venous thromboembolism (VTE) are two forms of thromboembolism that, although distinct, seem to share numerous risk factors. Concerning genetic risk factors, while many VTE genetic markers have been reported, inclu…
View article: Ovarian Cancer Overview: Molecular Biology and Its Potential Clinical Application
Ovarian Cancer Overview: Molecular Biology and Its Potential Clinical Application Open
Over the previous two decades, there has been a shift in the ovarian cancer paradigm to consider it as a multiplicity of disease types rather than a single disease, requiring specialized medical management from molecular diagnosis through …
View article: Canine mammary tumor risk is associated with polymorphisms in <i>RAD51</i> and <i>STK11</i> genes
Canine mammary tumor risk is associated with polymorphisms in <i>RAD51</i> and <i>STK11</i> genes Open
Cancer is a complex disease involving genetic and phenotypic changes. Several single nucleotide polymorphisms (SNPs) have been associated with the risk of breast cancer development in women; however, little is known regarding their influen…
View article: TP53 Arg72Pro polymorphism is associated with increased overall survival but not response to therapy in Portuguese/Caucasian patients with advanced cervical cancer
TP53 Arg72Pro polymorphism is associated with increased overall survival but not response to therapy in Portuguese/Caucasian patients with advanced cervical cancer Open
Identification of mechanisms that influence the therapeutic response and survival in patients with cancer is important. It is known that the genetic variability of the host, including presence of genetic polymorphisms in genes involved in …
View article: Relationship between clinical toxicities and <i>ERCC1</i> rs3212986 and <i>XRCC3</i> rs861539 polymorphisms in cervical cancer patients
Relationship between clinical toxicities and <i>ERCC1</i> rs3212986 and <i>XRCC3</i> rs861539 polymorphisms in cervical cancer patients Open
Background: Several studies have suggested that there are single nucleotide polymorphisms (SNPs) that can be considered potential biomarkers in the prognosis and therapeutic response of cancer patients. The present study investigated the a…