Jake Lin
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View article: Predicting stress-related disorders from laboratory biomarkers in Finnish electronic health records
Predicting stress-related disorders from laboratory biomarkers in Finnish electronic health records Open
Importance Stress-related disorders predict subsequent somatic conditions, suggesting these disorders involve systemic mechanisms, yet evidence from biomarkers remains fragmented across physiological systems. Objective To investigate wheth…
View article: Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukemia patients
Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukemia patients Open
Acute myeloid leukemia (AML) is an aggressive blood cancer characterized by poor survival outcomes. Further, due to the extreme molecular heterogeneity of the disease, drug treatment response varies from patient to patient. The variability…
View article: Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism
Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism Open
Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, the molecular mechanisms of the condition remain unknown. As intestinal problems and gut microbiota dysbiosis are associated with ASD developmen…
View article: Identifying health conditions in older adults in textual health records using deep learning-based natural language processing
Identifying health conditions in older adults in textual health records using deep learning-based natural language processing Open
Many clinically significant health conditions in older adults are underreported or only recorded in unstructured health records. These records, however, contain valuable information for patient care and prognosis. This study utilized 10.6 …
View article: Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights
Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights Open
View article: Identification of Health Conditions in Unstructured Health Records with Deep Learning-Based Natural Language Processing
Identification of Health Conditions in Unstructured Health Records with Deep Learning-Based Natural Language Processing Open
Importance Many clinically significant health conditions are frequently underreported, underdiagnosed or recorded only in unstructured textual health records, yet they contain critical information for patient assessment, care and prognosis…
View article: Genetic evidence for efficacy of targeting IL-2, IL-6 and TYK2 signalling in the prevention of type 1 diabetes: a Mendelian randomisation study
Genetic evidence for efficacy of targeting IL-2, IL-6 and TYK2 signalling in the prevention of type 1 diabetes: a Mendelian randomisation study Open
Aims/hypothesis We aimed to investigate the genetic evidence that supports the repurposing of drugs already licensed or in clinical phases of development for prevention of type 1 diabetes. Methods We obtained genome-wide association study …
View article: Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty
Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty Open
Frailty is a clinically relevant phenotype with significant gaps in our understanding of its etiology. We performed a genome-wide association study of frailty in FinnGen (N=500,737) and replicated the signals in the UK Biobank (N=429,463) …
View article: Exploring autism and autism co-occurring condition associations to elucidate multivariate genetic mechanisms and insights
Exploring autism and autism co-occurring condition associations to elucidate multivariate genetic mechanisms and insights Open
Background Autism is a partially heritable neurodevelopmental condition, and people with autism may also have other co-occurring conditions such as ADHD, anxiety disorders, depression, mental health issues, learning difficulty, physical he…
View article: Genetic evidence for efficacy of targeting IL-2, IL-6, and TYK2 signaling in prevention of type 1 diabetes: A Mendelian randomization study
Genetic evidence for efficacy of targeting IL-2, IL-6, and TYK2 signaling in prevention of type 1 diabetes: A Mendelian randomization study Open
Background Type 1 diabetes is an autoimmune disease, which leads to insulin dependence. We investigated genetic evidence to support the repurposing of seven drugs, already licensed or in clinical phases of development, for prevention of ty…
View article: Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection
Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection Open
View article: Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease
Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease Open
View article: Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukemia patients
Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukemia patients Open
Acute myeloid leukemia (AML) is a rare aggressive blood cancer without any long-term cure. Further, due to the extreme molecular heterogeneity of the disease, drug treatment response varies from patient to patient. The variability of drug …
View article: Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses
Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses Open
Identifying metabolic biomarkers of frailty, an age‐related state of physiological decline, is important for understanding its metabolic underpinnings and developing preventive strategies. Here, we systematically examined 168 nuclear magne…
View article: Supplementary Data: User guide from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies
Supplementary Data: User guide from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies Open
User guide for hemap web application.
View article: Supplementary Figures from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer
Supplementary Figures from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer Open
Supplementary Figures
View article: Supplementary Table 1-3 from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer
Supplementary Table 1-3 from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer Open
Supplementary Table 1, 2, 3
View article: Table S1 from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies
Table S1 from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies Open
Annotation table
View article: Supplementary Data from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies
Supplementary Data from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies Open
Supplementary Data includes Methods and Figures and Legends for Supplementary tables. Fig. S1: Sample-level quality control and pre-processing; Fig. S2: Two-dimensional representations of sample distances; Fig S3: Known vulnerabilities con…
View article: Data from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies
Data from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies Open
Large collections of genome-wide data can facilitate the characterization of disease states and subtypes, permitting pan-cancer analysis of molecular phenotypes and evaluation of disease context for new therapeutic approaches. We analyzed …
View article: Supplementary Figures from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer
Supplementary Figures from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer Open
Supplementary Figures
View article: Data from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer
Data from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer Open
Purpose: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with high mortality and a lack of targeted therapies. To identify and prioritize druggable targets, we performed genome analysis toget…
View article: Supplementary Table 6-7 from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer
Supplementary Table 6-7 from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer Open
Supplementary Table 6, 7
View article: Table S6 from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies
Table S6 from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies Open
Top 5 pathways per cluster and regulator genes
View article: Supplementary Table Legends from Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer
Supplementary Table Legends from Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer Open
Supplementary Table Legends
View article: Data from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies
Data from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies Open
Large collections of genome-wide data can facilitate the characterization of disease states and subtypes, permitting pan-cancer analysis of molecular phenotypes and evaluation of disease context for new therapeutic approaches. We analyzed …
View article: Supplementary Table 10 from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer
Supplementary Table 10 from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer Open
Supplementary Table 10
View article: Table S3 from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies
Table S3 from Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies Open
Analysis of targets of drugs in clinical use and in clinical trials.
View article: Supplementary Figure S3 from Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer
Supplementary Figure S3 from Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer Open
Figure S3. Correlation plots of autologous HNSCC cell line pairs utilizing kinomic profile
View article: Supplementary Table S21 from Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer
Supplementary Table S21 from Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer Open
Table S21: Table S21. Drug sensitivity and TP53 mutational status data on squamous cell carcinoma cell lines from COSMIC on Wee1/Chk1 Inhibitor (681460)