Jake Schnabl
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View article: It Takes a Village to Build a Brain: Defining the Heterogenous Glial and Neural Crest Contributions to Zebrafish Forebrain Development and Neurogenesis
It Takes a Village to Build a Brain: Defining the Heterogenous Glial and Neural Crest Contributions to Zebrafish Forebrain Development and Neurogenesis Open
During embryonic development of bilateral organisms, neurons send axons across the midline at specific points to connect the two halves of the nervous system with a commissure. Little is known about the cells at the midline that facilitate…
View article: Supplementary Movie 02A: Glial Membranes and Gfap Form Overlapping but Non-Coincident Glial Bridges at 22 hpf, Prior to Commissure Formation
Supplementary Movie 02A: Glial Membranes and Gfap Form Overlapping but Non-Coincident Glial Bridges at 22 hpf, Prior to Commissure Formation Open
Transverse slices of 22 hpf tg(gfap:mCherry-caax) (magenta) and immunolabeled with anti-AT (blue) and anti-Gfap (green). Video begins and ends laterally at each rostral cluster and passes through the midline. Anterior is to the left.
View article: Supplementary Movie 01C: Olig2+ Cells Densely Populate the Telencephalon and Extend Processes Towards the AC
Supplementary Movie 01C: Olig2+ Cells Densely Populate the Telencephalon and Extend Processes Towards the AC Open
3D rendering of confocal z-stack of a 48 hpf tg(olig2:gfp) (green) embryo labeled with anti-AT (blue). Left panel rotates clockwise around the anterior- posterior vertical axis, starting from a ventral perspective. The right panel shows th…
View article: Supplementary Movie 04: Pioneering Axons of the AC Navigate in Association with and Through gfap+ Glial Membranes
Supplementary Movie 04: Pioneering Axons of the AC Navigate in Association with and Through gfap+ Glial Membranes Open
View article: Supplementary Movie 06C: The olig2+ Population has Greatly Increased in the Telencephalon by 28 hpf
Supplementary Movie 06C: The olig2+ Population has Greatly Increased in the Telencephalon by 28 hpf Open
3D rendering of tg(olig2:gfp) (green) forebrain immunolabeled with anti-AT (blue). Left panel begins from a frontal perspective and rotates clockwise 270◦ around the anterior-posterior axis. The right panel is the same sample and begins fr…
View article: Supplementary Movie 01E: The 48 hpf Forebrain Commissural Cell Architecture Exhibits Many Multiprocess Cell Types Which Interact With the Forebrain Commissures
Supplementary Movie 01E: The 48 hpf Forebrain Commissural Cell Architecture Exhibits Many Multiprocess Cell Types Which Interact With the Forebrain Commissures Open
Movie of 48 hpf model showing each cell type observed relative to the forebrain commissures individually, in the order of: forebrain, axons, olig2+ cells, flk+ cells, Zrfs, and all channels combined. After individual cell models, channels …
View article: Supplementary Movie 06A: olig2+ Cells Heavily Populate the Diencephalon and Lightly Populate the Telencephalon at 22 hpf
Supplementary Movie 06A: olig2+ Cells Heavily Populate the Diencephalon and Lightly Populate the Telencephalon at 22 hpf Open
3D rendering of tg(olig2:gfp) (green) forebrain immunolabeled with anti-AT (blue). Left panel begins from a frontal perspective and rotates clockwise 360◦ around the anterior-posterior axis. The right panel is the same sample and begins fr…
View article: Supplementary Movie 09C: fli1a+ Cells Form Vascular-Like Structures in the Forebrain, While Superficially Coating the Forebrain at 36 hpf
Supplementary Movie 09C: fli1a+ Cells Form Vascular-Like Structures in the Forebrain, While Superficially Coating the Forebrain at 36 hpf Open
3D rendering of a 36 hpf tg(fli1a:gfp) (green) forebrain immunolabeled with anti-AT (blue). Left panel begins from a frontal perspective and rotates clockwise 300◦ around the anterior-posterior axis. The right panel is the same sample and …
View article: Supplementary Movie 10: flk+ Cells Form Vascular Structures Throughout the Forebrain, with Midline Structures Connecting the Diencephalon and Telencephalon
Supplementary Movie 10: flk+ Cells Form Vascular Structures Throughout the Forebrain, with Midline Structures Connecting the Diencephalon and Telencephalon Open
3D rendering of a 48 hpf tg(flk1:gfp (green); gfap:mCherry-caax (magenta)) forebrain immunolabeled with anti-AT (blue). Left panel begins from a frontal perspective and rotates clockwise 360◦ around the anterior-posterior axis. The right p…
View article: Supplementary Movie 03: Time-Lapse Microscopy Showing First Pathfinding Axons of the POC and AC
Supplementary Movie 03: Time-Lapse Microscopy Showing First Pathfinding Axons of the POC and AC Open
View article: Supplementary Movie 05C: 3D Visualization of gfap+ Cells with Ventral Commissural Glial Morphology are Found Ventral to POC
Supplementary Movie 05C: 3D Visualization of gfap+ Cells with Ventral Commissural Glial Morphology are Found Ventral to POC Open
Transplanted population of cells at 28 hpf from tg(gfap:nls-mcherry) (red) and tg(gfap:gfp-caax) (green) embryo labeled with anti-AT (blue). Axes approximately correspond to x = lateral, y = dorsal, z = anterior.
View article: Supplementary Movie 09B: fli1a+ Cells Follow the Tract of the AC as They Form Telencephalic Projections at 28 hpf
Supplementary Movie 09B: fli1a+ Cells Follow the Tract of the AC as They Form Telencephalic Projections at 28 hpf Open
3D rendering of a 28 hpf tg(fli1a:gfp) (green) forebrain immunolabeled with anti-AT (blue). Left panel begins from a frontal perspective and rotates clockwise 360◦ around the anterior-posterior axis. The right panel is the same sample and …
View article: Supplementary Movie 08A: gfap+ and olig2+ Lineage Neurons are Evident at 24 hpf
Supplementary Movie 08A: gfap+ and olig2+ Lineage Neurons are Evident at 24 hpf Open
Scrolling through frontal z-stack of a 24 hpf tg(gfap:nls-mcherry (magenta); olig2:gfp (green)) forebrain labeled with anti-HuC/D (blue). Movie begins at the most superficial/anterior slice and scrolls to deeper/more posterior slices, span…
View article: Supplementary Movie 11A: The Early, 22 hpf, Forebrain Commissural Cell Architecture is Constructed from Several Interacting Cell Types
Supplementary Movie 11A: The Early, 22 hpf, Forebrain Commissural Cell Architecture is Constructed from Several Interacting Cell Types Open
Movie of 22 hpf model starting with all cells then showing each cell type observed relative to the forebrain commissures individually, in the order of: forebrain, axons, gfap+ glia, olig2+ cells, Zrfs, fli1a+ cells, and all channels combin…
View article: Supplementary Movie 05B: 3D Visualization of gfap+ Cells with Dorsal Commissural Glial Morphology are Found Dorsal to the POC
Supplementary Movie 05B: 3D Visualization of gfap+ Cells with Dorsal Commissural Glial Morphology are Found Dorsal to the POC Open
Transplanted population of cells at 28 hpf from tg(gfap:nls-mcherry) (red) and tg(gfap:gfp-caax) (green) embryo labeled with anti-AT (blue). Axes approximately correspond to x = lateral, y = dorsal, z = anterior.
View article: Supplementary Movie 05A: 3D Visualization of gfap+ Cells with Radial Glial Morphology Which Surround the POC
Supplementary Movie 05A: 3D Visualization of gfap+ Cells with Radial Glial Morphology Which Surround the POC Open
Transplanted population of cells at 28 hpf from tg(gfap:nls-mcherry) (red) and tg(gfap:gfp-caax) (green) embryo labeled with anti-AT (blue). Axes approximately correspond to x = lateral, y = dorsal, z = anterior.
View article: Supplementary Movie 06D: olig2+ Populations Have Greatly Expanded by 36 hpf and Exhibit Many Multiprocess Contacts with the Forebrain Commissures
Supplementary Movie 06D: olig2+ Populations Have Greatly Expanded by 36 hpf and Exhibit Many Multiprocess Contacts with the Forebrain Commissures Open
3D rendering of tg(olig2:gfp) (green) forebrain immunolabeled with anti-AT (blue). Left panel begins from a frontal perspective and rotates clockwise 270◦around the anterior-posterior axis. The right panel is the same sample and begins fro…
View article: Supplementary Movie 02C: The Gfap+ Glial Bridge is Superficial to the Forebrain Commissures, While Glial Membranes are Densely Coincident with POC Axons at 28 hpf
Supplementary Movie 02C: The Gfap+ Glial Bridge is Superficial to the Forebrain Commissures, While Glial Membranes are Densely Coincident with POC Axons at 28 hpf Open
Transverse slices of 28 hpf tg(gfap:mCherry-caax) (magenta) and immunolabeled with anti-AT (blue) and anti-Gfap (green). Video begins and ends laterally at each rostral cluster and passes through the midline. Anterior is to the left.
View article: Zebrafish Forebrain Cellular Characterization Supplemental Vidoes
Zebrafish Forebrain Cellular Characterization Supplemental Vidoes Open
During embryonic development of bilateral organisms, neurons send axons across the midline at specific points to connect the two halves of the nervous system with a commissure.Little is known about the cells at the midline that facilitate …
View article: Supplementary Movie 05D: 3D Rendering of gfap+Cells with Radial Glial Morphology
Supplementary Movie 05D: 3D Rendering of gfap+Cells with Radial Glial Morphology Open
View article: Supplementary Movie 01B: gfap+ Glial Cell Membranes Overlap with Axons of Forebrain Commissures
Supplementary Movie 01B: gfap+ Glial Cell Membranes Overlap with Axons of Forebrain Commissures Open
3D rendering of confocal z-stack of a 48 hpf tg(gfap:gfp-caax) (green) embryo labeled with anti-AT (blue). Left panel rotates counterclockwise around the anterior-posterior vertical axis, starting from a dorsal perspective. The right panel…
View article: Supplementary Movie 01D: fli1a+ Cells Track the Tract of the AC to Form Vasculature in the Telencephalon
Supplementary Movie 01D: fli1a+ Cells Track the Tract of the AC to Form Vasculature in the Telencephalon Open
3D rendering of confocal z-stack of a 48 hpf tg(fli1a:gfp) (green) embryo labeled with anti-AT (blue). Left panel rotates clockwise around the anterior-posterior vertical axis, starting from a ventral perspective. The right panel shows the…
View article: Supplementary Movie 02B: The Gfap+ Glial Bridge is Superficial to the Forebrain Commissures, While Glial Membranes are Instead Coincident with POC Axons at 24 hpf
Supplementary Movie 02B: The Gfap+ Glial Bridge is Superficial to the Forebrain Commissures, While Glial Membranes are Instead Coincident with POC Axons at 24 hpf Open
Transverse slices of 24 hpf tg(gfap:mCherry-caax) (magenta) and immunolabeled with anti-AT (blue) and anti-Gfap (green). Video begins and ends laterally at each rostral cluster and passes through the midline. Anterior is to the left.
View article: Supplementary Movie 09A:fli1a+ Cells Form Vascular-Like Processes Ventral and Superficial to the POC at 24 hpf
Supplementary Movie 09A:fli1a+ Cells Form Vascular-Like Processes Ventral and Superficial to the POC at 24 hpf Open
3D rendering of a 24 hpf tg(fli1a:gfp) (green) forebrain immunolabeled with anti-AT (blue). Left panel begins from a frontal perspective and rotates counterclockwise 360◦ around the anterior-posterior axis. The right panel is the same samp…
View article: Supplementary Movie 05F: 3D Rendering of gfap+ Cells with Ventral Commissural Glial Morphology
Supplementary Movie 05F: 3D Rendering of gfap+ Cells with Ventral Commissural Glial Morphology Open
View article: Supplementary Movie 05E: 3D Rendering of gfap+ Cells with Dorsal Commissural Glial Morphology are Found Dorsal to the POC
Supplementary Movie 05E: 3D Rendering of gfap+ Cells with Dorsal Commissural Glial Morphology are Found Dorsal to the POC Open
View article: Supplementary Movie 02D: The Gfap+ Glial Bridge is Superficial to the Forebrain Commissures, While Glial Membranes are Instead Coincident with POC Axons at 36 hpf
Supplementary Movie 02D: The Gfap+ Glial Bridge is Superficial to the Forebrain Commissures, While Glial Membranes are Instead Coincident with POC Axons at 36 hpf Open
Transverse slices of 36 hpf tg(gfap:mCherry-caax) (magenta) and immunolabeled with anti-AT (blue) and anti-Gfap (green). Video begins and ends laterally at each rostral cluster and passes through the midline. Anterior is to the left.
View article: Supplementary Movie 11B: The 28 hpf Forebrain Commissural Cell Architecture Exhibits Differently Timed Cell Contributions Between the Telencephalon and Diencephalon
Supplementary Movie 11B: The 28 hpf Forebrain Commissural Cell Architecture Exhibits Differently Timed Cell Contributions Between the Telencephalon and Diencephalon Open
Movie of 28 hpf model showing each cell type observed relative to the forebrain commissures individually, in the order of: forebrain, axons, olig2+ cells, gfap+ glia, Zrfs, fli1a+ cells, and all channels combined. After individual cell mod…
View article: Supplementary Movie 08B: gfap+ and olig2+ Lineage Neurons Have Increased in Number at 28 hpf, but Differentially Contribute to Telencephalic Versus Diencephalic Populations
Supplementary Movie 08B: gfap+ and olig2+ Lineage Neurons Have Increased in Number at 28 hpf, but Differentially Contribute to Telencephalic Versus Diencephalic Populations Open
Scrolling through frontal z-stack of a 28 hpf tg(gfap:nls-mcherry) (magenta); olig2:gfp (green)) forebrain labeled with anti-HuC/D (blue). Movie begins at the most superficial/anterior slice and scrolls to deeper/more posterior slices, spa…
View article: Supplementary Movie 07C: Telencephalic and Diencephalic gfap+ and olig2+ Differentially Contribute to Glial Lineages
Supplementary Movie 07C: Telencephalic and Diencephalic gfap+ and olig2+ Differentially Contribute to Glial Lineages Open
Scrolling through a frontal z-stack of a 28 hpf tg(gfap:nls-mCherry) (magenta) olig2:gfp (green) double transgenic embryo labeled for pH3 (blue). Movie begins at the most superficial/anterior slice and scrolls to deeper/more posterior slic…