Explanipedia

Six‐ Versus Four‐Hour Iohexol Clearance for Glomerular Filtration Rate Measurement in Living Kidney Donor Candidates Open

S. Ali Husain, Jacob S. Stevens, Sumit Mohan · 2025

Acute Kidney Injury Requiring Dialysis After Pediatric Heart Transplant Open

Amy R. Lipman, Irene D. Lytrivi, Hilda Fernández, Áine Lynch, Miko Yu , et al. · 2024

Background Acute kidney injury (AKI) is a common complication of pediatric heart transplant, with a subset of patients developing severe AKI requiring dialysis (AKI‐D). We aimed to identify the epidemiology, risk factors, and outcomes of p…

A functional group–guided approach to aptamers for small molecules Open

Kyung-Ae Yang, N. Mitchell, Saswata Banerjee, Zhenzhuang Cheng, Steven K. Taylor , et al. · 2023

Aptameric receptors are important biosensor components, yet our ability to identify them depends on the target structures. We analyzed the contributions of individual functional groups on small molecules to binding within 27 target-aptamer…

Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysis Open

Miah T. Li, Adarsh Ramakrishnan, Miko Yu, Emily Daniel, Vanessa Sandra , et al. · 2023

Delayed graft function (DGF) is a frequent complication of kidney transplantation, but its impact on long- and short-term transplant outcomes is unclear. We conducted a systematic literature search for studies published from 2007 to 2020 i…

Timed Creatinine Clearance and Measured Glomerular Filtration Rate in Living Kidney Donors Open

S. Ali Husain, Jacob S. Stevens, Kristen L. King, Shelief Y. Robbins-Juarez, Matthew J. Cohen , et al. · 2022

Assessment of predonation glomerular filtration rate (GFR) is a key aspect of the evaluation of potential living kidney donors. In the United States, measurement of donor GFR is a regulatory requirement and most commonly assessed using 24-…

Kidney nonprocurement in deceased donors with acute kidney injury Open

Kathleen Yu, S. Ali Husain, Kristen L. King, Jacob S. Stevens, Chirag R. Parikh , et al. · 2022

Background Acute kidney injury (AKI) is common in deceased organ donors and is associated with high rates of kidney discard by transplant centers. High discard rates may consequently drive nonprocurement of these kidneys by organ procureme…

Snapshots of nascent RNA reveal cell- and stimulus-specific responses to acute kidney injury Open

Tian Shen, Jacob Stauber, Katherine Xu, Alexandra Jacunski, Neal Paragas , et al. · 2022

The current strategy to detect acute injury of kidney tubular cells relies on changes in serum levels of creatinine. Yet serum creatinine (sCr) is a marker of both functional and pathological processes and does not adequately assay tubular…

Optimizing Perioperative Renal Replacement Therapy for Patients Undergoing Cardiac Surgical Procedures Requiring Cardiopulmonary Bypass Open

Jacob S. Stevens, Jonathan Hastie, Jessica Spellman, Aaron Mittel, James Beck , et al. · 2022

Coronary artery disease is highly prevalent in patients with end-stage renal disease (ESRD), and cardiovascular complications remain the most common cause of death in this patient population. Accordingly, many cardiac surgical procedures r…

Vancomycin-Associated Cast Nephropathy: Reality or Fantasy? Open

Michael B. Stokes, Jacob S. Stevens · 2021

Vancomycin is a glycopeptide antibiotic commonly used for severe gram-positive bacterial infections, notably methicillin-resistant Staphylococcus aureus. AKI occurs in 5%–43% of patients who are vancomycin treated (1–3), and is commonly (5…

Kidney Replacement Therapy for Patients Requiring Cardiopulmonary Bypass Support during Cardiac Surgery Open

Jacob S. Stevens, Jai Radhakrishnan · 2021

Introduction Patients receiving kidney replacement therapy (KRT) preoperatively who require cardiac surgery with cardiopulmonary bypass support present a particular challenge for the nephrologist. The earliest patient series from 1968 (1) …

Elevated Neutrophil Gelatinase-Associated Lipocalin Is Associated With the Severity of Kidney Injury and Poor Prognosis of Patients With COVID-19 Open

Katherine Xu, Ning Shang, Abraham Levitman, Alexa Corker, Satoru Kudose , et al. · 2021

In the patients with COVID-19, uNGAL level was quantitatively associated with histopathologic injury (ATI), loss of kidney function (AKI), and severity of patient outcomes.

Ethylene Glycol Intoxication Requiring ECMO Support Open

Raphael J. Rosen, Shelief Y. Robbins-Juarez, Jacob S. Stevens · 2021

Ethylene glycol is commonly used in antifreeze, and ingestion of even a small amount can result in acute kidney injury, severe metabolic acidosis, and neurological injury. When cases are recognized early, treatment involves administration …

Successful Use of Arteriovenous Graft for Hemodialysis Access After Left Ventricular Assist Device Placement Open

Katherine Toma, Jacob S. Stevens, Nicholas J. Morrissey, M. Yuzefpolskaya, Jai Radhakrishnan , et al. · 2021

Diabetic ketoacidosis and mortality in COVID-19 infection Open

Jacob S. Stevens, Magdalena Bogun, Donald J. McMahon, Jason Zucker, Paul Kurlansky , et al. · 2021

Urine Test Predicts Kidney Injury and Death in COVID-19 Open

Katherine Xu, Ning Shang, Abraham Levitman, Alexa Corker, Satoru Kudose , et al. · 2021

Background Kidney injury is common in COVID-19 infection, but serum creatinine (SCr) is not a sensitive or specific marker of kidney injury. We hypothesized that molecular markers of tubular injury could diagnose COVID-19 associated kidney…

Increased Mortality Associated with Hypermagnesemia in Severe COVID-19 Illness Open

Jacob S. Stevens, Andrew A. Moses, Thomas L. Nickolas, S. Ali Husain, Sumit Mohan · 2021

Key Points Hypermagnesemia is common in patients admitted with coronavirus disease 2019. The development of hypermagnesemia in coronavirus disease 2019 is associated with renal failure and markers of high cell turnover. In adjusted models,…

Protocol for Local On-Site Dialysate Production for Continuous Renal Replacement Therapy during the COVID-19 Pandemic Open

Andrew A. Moses, Jacob S. Stevens, Derek M. Fine, Robert Carrera, Alina Li , et al. · 2021

Key Points Because dialysate production in a hospital is not commonly performed, the technique has not been generalized to commonly available materials. On-site dialysate production may be necessary when demand is high, as it was during th…

Post-acute COVID-19 syndrome Open

Ani Nalbandian, Kartik Sehgal, Aakriti Gupta, Mahesh V. Madhavan, Claire McGroder , et al. · 2021

Continuous renal replacement therapy and the COVID pandemic Open

Jacob S. Stevens, Juan Carlos Q. Velez, Sumit Mohan · 2021

Severe COVID‐19 illness and the consequent cytokine storm and vasodilatory shock commonly lead to ischemic acute kidney injury (AKI). The need for renal replacement therapies (RRTs) in those with the most severe forms of AKI is considerabl…

Diabetic Ketoacidosis and Mortality in COVID-19 Infection Open

Jacob S. Stevens, Magdalena Bogun, Donald J. McMahon, Jason Zucker, Paul Kurlansky , et al. · 2021

High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy Open

Jacob S. Stevens, Kristen L. King, Shelief Y. Robbins-Juarez, Pascale Khairallah, Katherine Toma , et al. · 2020

Introduction A large proportion of patients with COVID-19 develop acute kidney injury (AKI). While the most severe of these cases require renal replacement therapy (RRT), little is known about their clinical course. Methods We describe the…

Optimizing Kidney Replacement Therapy During the COVID-19 Pandemic Across a Complex Healthcare System Open

Jane Akomeah, Aljenica Apostol, Esteen Barnes, Chaim Charytan, Uvannie Enriquez , et al. · 2020

The unprecedented surge of nephrology inpatients needing kidney replacement therapy placed hospital systems under extreme stress during the COVID-19 pandemic. In this article, we describe the formation of a cross campus “New-York Presbyter…

Mortality and renal outcomes of patients with severe COVID-19 treated in a provisional intensive care unit Open

Erin Hittesdorf, Oliver Panzer, David Wang, Jacob S. Stevens, Jonathan Hastie , et al. · 2020

Rule Out Acute Kidney Injury in the Emergency Department With a Urinary Dipstick Open

Jacob S. Stevens, Katherine Xu, Alexa Corker, Tejashree S. Gopal, Osman R. Sayan , et al. · 2020

Dashboards to Facilitate Nephrology Disaster Planning in the COVID-19 Era Open

Jacob S. Stevens, Katherine Toma, Susan Tanzi-Pfeifer, Maya K. Rao, Sumit Mohan , et al. · 2020

The emergence of the coronavirus disease 2019 (COVID-19) pandemic has placed tremendous stress on health care systems. While there was early recognition of the need for rapid upscaling and sourcing for ventilatory support, the need for ren…

Outcomes for Patients With COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis Open

Shelief Y. Robbins-Juarez, Long Qian, Kristen L. King, Jacob S. Stevens, S. Ali Husain , et al. · 2020

Kidney dysfunction is common among patients with COVID-19, and patients who develop AKI have inferior outcomes. Additional research into management and potential mechanisms of this association is needed.

Presentation and Outcomes of Patients with ESKD and COVID-19 Open

Anthony M. Valeri, Shelief Y. Robbins-Juarez, Jacob S. Stevens, Wooin Ahn, Maya K. Rao , et al. · 2020

Significance Statement Immunosuppression and a high prevalence of comorbidities among patients with ESKD on dialysis raise concerns that such patients may have an elevated risk of severe coronavirus disease 2019 (COVID-19). However, the ou…

Case 17-2020: A 68-Year-Old Man with Covid-19 and Acute Kidney Injury Open

Meghan E. Sise, Meridale V. Baggett, Jo-Anne O. Shepard, Jacob S. Stevens, Eugene P. Rhee · 2020

A Man with Covid-19 and Acute Kidney Injury A 68-year-old man was admitted to the hospital with fever, shortness of breath, and acute kidney injury. Testing of a nasopharyngeal swab for SARS-CoV-2 ...

Kidney nonprocurement in solid organ donors in the United States Open

Kathleen Yu, Kristen L. King, S. Ali Husain, Geoffrey K. Dube, Jacob S. Stevens , et al. · 2020

Lactate dehydrogenase 5: identification of a druggable target to reduce oxaluria Open

Jacob S. Stevens, Qais Al‐Awqati · 2019

Excessive excretion of oxalate in the urine results in the formation of calcium oxalate crystals and subsequent kidney stone formation. Severe forms of hyperoxaluria, including genetic forms and those that result from ethylene glycol poiso…

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