Janet Sultana
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View article: Identifying synergistic combinations of repurposed treatments for Alzheimer’s Disease
Identifying synergistic combinations of repurposed treatments for Alzheimer’s Disease Open
There is considerable opportunity to fast-track novel treatments for Alzheimer's Disease (AD) through repurposing of existing licensed medications as a way of complementing ongoing drug discovery efforts. Given the complex interplay betwee…
View article: Effect of Prolonged Screen Time in Children: Developmental and Behavioral Concern
Effect of Prolonged Screen Time in Children: Developmental and Behavioral Concern Open
Background: Prolonged screen time (time spent on digital devices) among children has become a global concern due to its detrimental effects on their development and behavior. Objective: This study investigated the adverse effects of prolon…
View article: Transcriptome Analysis of TGFBI Knockdown vs Normal Corneal Epithelial Cells: Implications for TGFBI Corneal Dystrophy Treatment
Transcriptome Analysis of TGFBI Knockdown vs Normal Corneal Epithelial Cells: Implications for TGFBI Corneal Dystrophy Treatment Open
This study aimed to clarify the role Transforming Growth Factor Beta Induced ( TGFBI ) protein plays in corneal epithelial homeostasis by using RNA interference and to explore the possibility of gene therapy as a treatment modality for the…
View article: Effects of Russian Electrical Stimulation on Knee Osteoarthritis v1
Effects of Russian Electrical Stimulation on Knee Osteoarthritis v1 Open
This protocol outlines a randomized controlled trial (RCT) to evaluate the effectiveness of Russian electrical stimulation–enhanced quadriceps strengthening exercise compared with strengthening exercise alone in 70 older adults with knee o…
View article: Drug Repositioning for Alzheimer’s Disease: A Delphi Consensus and Stakeholder Consultation
Drug Repositioning for Alzheimer’s Disease: A Delphi Consensus and Stakeholder Consultation Open
Background Alzheimer’s Disease (AD) is an escalating global challenge, with over 40 million people affected and this number is projected to increase to over 100 million by 2050. While amyloid-targeting antibody treatments (lecanumab and do…
View article: Preserving residual kidney function in persons on peritoneal dialysis: the role of pharmacotherapy
Preserving residual kidney function in persons on peritoneal dialysis: the role of pharmacotherapy Open
View article: The outcomes of goal-oriented medication reviews for the elderly: current research and future directions
The outcomes of goal-oriented medication reviews for the elderly: current research and future directions Open
View article: Prevalence of Opioid Use in Nursing Homes Over the Last Decade: A Systematic Literature Review
Prevalence of Opioid Use in Nursing Homes Over the Last Decade: A Systematic Literature Review Open
Background: Despite global concerns of an opioid epidemic, there is no systematic literature review on how frequently these drugs are used in nursing home (NH) populations, including those living with dementia. Objective: This systematic r…
View article: Nivolumab Safety in Renal Cell Carcinoma: A Case Report
Nivolumab Safety in Renal Cell Carcinoma: A Case Report Open
Nivolumab is used to treat several different types of cancers. Although it is generally considered to be effective and well-tolerated, it has been associated with adverse effects requiring discontinuation of treatment, like many other drug…
View article: Integrating Software Into Hospital Quality Structures: What Practices Do Pharmaceutical Inspector Co-Operation Scheme (PIC/S) Guidelines Recommend?
Integrating Software Into Hospital Quality Structures: What Practices Do Pharmaceutical Inspector Co-Operation Scheme (PIC/S) Guidelines Recommend? Open
View article: Real world data for rare diseases research: The beginner’s guide to registries
Real world data for rare diseases research: The beginner’s guide to registries Open
Introduction Rare disease research has specific challenges that can be addressed using registries.Areas covered There are at least three different types of registries: patient registries, disease registries, and product registries. Patient…
View article: Communicating for the Safe Use of Medicines: Progress and Directions for the 2020s Promoted by the Special Interest Group of the International Society of Pharmacovigilance
Communicating for the Safe Use of Medicines: Progress and Directions for the 2020s Promoted by the Special Interest Group of the International Society of Pharmacovigilance Open
View article: Pharmacological treatment for transforming growth factor beta induced corneal dystrophies: what is the way forward?
Pharmacological treatment for transforming growth factor beta induced corneal dystrophies: what is the way forward? Open
KEYWORDS: Corneal dystrophydrug repurposingorphan drugsrare diseasetransforming growth factor beta induced
View article: The pharmacological treatment of granulomatosis with polyangiitis: a review of clinical trials registered in clinicaltrials.gov and the International Clinical Trials Registry Platform
The pharmacological treatment of granulomatosis with polyangiitis: a review of clinical trials registered in clinicaltrials.gov and the International Clinical Trials Registry Platform Open
To date, there is no published overview of the drug pipeline in granulomatosis with polyangiitis (GPA), a rare disease. The aim of this study was to identify clinical trials from two study repositories. A review of clinical trials was cond…
View article: RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus
RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus Open
Drug repositioning and repurposing has proved useful in identifying new treatments for many diseases, which can then rapidly be brought into clinical practice. Currently, there are few effective pharmacological treatments for Lewy body dem…
View article: Corrigendum: Editorial: The mechanisms of action of anti-SARS-CoV-2 drugs
Corrigendum: Editorial: The mechanisms of action of anti-SARS-CoV-2 drugs Open
[This corrects the article DOI: 10.3389/fphar.2022.894310.].
View article: Editorial: Overcoming boundaries in public health: Advances in international and global health
Editorial: Overcoming boundaries in public health: Advances in international and global health Open
EDITORIAL article Front. Public Health, 14 October 2022Sec. Infectious Diseases – Surveillance, Prevention and Treatment Volume 10 - 2022 | https://doi.org/10.3389/fpubh.2022.1044157
View article: Development and testing of diagnostic algorithms to identify patients with acromegaly in Southern Italian claims databases
Development and testing of diagnostic algorithms to identify patients with acromegaly in Southern Italian claims databases Open
View article: Editorial: The Mechanisms of Action of Anti-SARS-CoV-2 Drugs
Editorial: The Mechanisms of Action of Anti-SARS-CoV-2 Drugs Open
EDITORIAL article Front. Pharmacol., 04 April 2022Sec. Experimental Pharmacology and Drug Discovery https://doi.org/10.3389/fphar.2022.894310
View article: Overview of the <scp>European post‐authorisation study</scp> register post‐authorization studies performed in Europe from September 2010 to December 2018
Overview of the <span>European post‐authorisation study</span> register post‐authorization studies performed in Europe from September 2010 to December 2018 Open
Background The European post‐authorisation study (EU PAS) register is a repository launched in 2010 by the European Medicines Agency (EMA). All EMA‐requested PAS, commonly observational studies, must be recorded in this register. Multi‐dat…
View article: COVID-19 mRNA vaccine safety, immunogenicity, and effectiveness in a hospital setting: confronting the challenge
COVID-19 mRNA vaccine safety, immunogenicity, and effectiveness in a hospital setting: confronting the challenge Open
View article: Anti-hypertensive drugs deprescribing: an updated systematic review of clinical trials
Anti-hypertensive drugs deprescribing: an updated systematic review of clinical trials Open
View article: Comparison of Direct Oral Anticoagulant Use for the Treatment of Non-Valvular Atrial Fibrillation in Pivotal Clinical Trials vs. the Real-World Setting: A Population-Based Study from Southern Italy
Comparison of Direct Oral Anticoagulant Use for the Treatment of Non-Valvular Atrial Fibrillation in Pivotal Clinical Trials vs. the Real-World Setting: A Population-Based Study from Southern Italy Open
Patients enrolled into pivotal randomized controlled trials (RCTs) may differ substantially from those treated in a real-world (RW) setting, which may result in a different benefit–risk profile. The aim of the study was to assess the exter…
View article: Advocating a person-centered care approach to drug safety
Advocating a person-centered care approach to drug safety Open
KEYWORDS: Action researchdrug safetynarrativespatient engagementperson-centered careperson-centered outcomes
View article: Caserta Record Linkage Database
Caserta Record Linkage Database Open
The Italian publicly funded National Health Service (NHS) provides universal health care, mainly free of charge, to all NHS beneficiaries, that is, the whole Italian population. The NHS has three levels of management. At the national level…
View article: <p>Survival of Hospitalized COVID-19 Patients in Northern Italy: A Population-Based Cohort Study by the ITA-COVID-19 Network</p>
Survival of Hospitalized COVID-19 Patients in Northern Italy: A Population-Based Cohort Study by the ITA-COVID-19 Network Open
The high fatality rate observed in the study (28% at 30 days) suggests that studies should focus on death as primary endpoint during a follow-up of at least one month.
View article: Challenges for Drug Repurposing in the COVID-19 Pandemic Era
Challenges for Drug Repurposing in the COVID-19 Pandemic Era Open
The coronavirus disease (COVID-19) pandemic has affected an estimated 16 million persons and caused 0.6 million deaths worldwide by September 2020. The pandemic has led to a rush to repurpose existing drugs, although the underlying evidenc…
View article: Beyond the budget silo approach: estimating health system sustainability for future dementia drugs
Beyond the budget silo approach: estimating health system sustainability for future dementia drugs Open
Aim of the study: to analyze the impact of a hypothetic disease-modifying drug (DMD) on the estimated costs of dementia sustained by the National Health System (NHS) based on current real-world data.We performed our analysis on the Caserta…
View article: Drug repositioning and repurposing for Alzheimer disease
Drug repositioning and repurposing for Alzheimer disease Open
View article: Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Death in Patients Hospitalised with COVID-19: A Retrospective Italian Cohort Study of 43,000 Patients
Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Death in Patients Hospitalised with COVID-19: A Retrospective Italian Cohort Study of 43,000 Patients Open