Mark Jakob
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View article: Subjective Discomfort during Botulinumtoxin Injections Dependent on Injection Site and Needle Size: A Comparison Between 30G, 33G and 34G Needles
Subjective Discomfort during Botulinumtoxin Injections Dependent on Injection Site and Needle Size: A Comparison Between 30G, 33G and 34G Needles Open
Background Botulinumtoxin application in the face is amongst the most common aesthetic procedures in the head and neck region. It also has numerous medical uses. One of the main reasons for patients to refrain from it is the subjective dis…
View article: MicroRNA-182-5p and microRNA-205-5p as potential biomarkers for further prognostic stratification of p16-positive oropharyngeal squamous cell carcinoma
MicroRNA-182-5p and microRNA-205-5p as potential biomarkers for further prognostic stratification of p16-positive oropharyngeal squamous cell carcinoma Open
Background: Non-coding microRNAs (miR) regulate gene expression on post transcriptional level and open new perspectives of prognostic stratification as potential biomarkers of head and neck cancer. The aim was to investigate diagnostic and…
View article: Lipedema in a male patient: report of a rare case – management and review of the literature
Lipedema in a male patient: report of a rare case – management and review of the literature Open
Objective: Lipedema is a relatively common yet debilitating and often misdiagnosed lipodystrophy that mainly affects females. Very little is known about the etiology and pathophysiology of the disease. However, due to its high preference f…
View article: Long‐term incidence of upper extremity venous obstruction in implantable cardioverter defibrillator patients
Long‐term incidence of upper extremity venous obstruction in implantable cardioverter defibrillator patients Open
Background Very little is known about the long‐term prevalence of severe venous obstruction and occlusion in patients with transvenous implantable cardioverter‐defibrillator leads. The objective of the current investigation was to elucidat…
View article: Clinical features of sarcoidosis patients presenting with head and neck manifestations
Clinical features of sarcoidosis patients presenting with head and neck manifestations Open
Background and Aims Sarcoidosis is a multi-system granulomatous disease that most commonly manifests pulmonary (about 90 % ). The extrapulmonary manifestation is rare but also occurs in the head and neck area. Here it is essential that a f…
View article: Cancer Stem Cell Markers in Squamous Cell Carcinomas of the Salivary Glands
Cancer Stem Cell Markers in Squamous Cell Carcinomas of the Salivary Glands Open
Background: Cancer stem cells (CSC) are cells that exhibit stem cell properties and are pivotal in tumor biology. CSC markers have been described for many tumorous entities. However, to this date, there is no data on CSC markers in respect…
View article: Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Show Comparable Functionality to Their Autologous Origin
Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Show Comparable Functionality to Their Autologous Origin Open
A multimodal therapeutic approach involving radiotherapy is required when treating head and neck squamous cell carcinoma. However, radiotherapy is restricted due to its high risk for damages to the surrounding healthy tissue of the treated…
View article: Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC
Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC Open
Purpose Cancer stem cells (CSCs) are held accountable for the progress of head and neck squamous cell carcinoma (HNSCC). In the presented study, the authors evaluated the prognostic value of CSC markers in two particular HNSCC cohorts. Met…
View article: Importance of microRNAs as potential biomarkers for oral carcinoma
Importance of microRNAs as potential biomarkers for oral carcinoma Open
Background The number of miRNA expression profiling studies and research about miRNA-based biomarkers in oral squamous cell carcinoma (OSCC) has recently increased, particularly in the Asian region, whereas research about miRNA-based bioma…
View article: Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC
Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC Open
Introduction Cancer stem cells (CSCs) are hold accountable for the progress of head and neck squamous cell carcinoma (HNSCC). In the presented study, we evaluated the prognostic value of CSC markers in two particular HNSCC cohorts.
View article: Clinical features of sarcoidosis in head and neck area
Clinical features of sarcoidosis in head and neck area Open
Background and Aims Sarcoidosis is a multi-system granulomatous disease that most commonly manifests pulmonary (about 90 %). The extrapulmonary manifestation is rare but also occurs in the head and neck area. Here it is essential that a fi…
View article: Prognostic impact of additional HPV-typing in p16-stratified advanced oropharyngeal squamous cell carcinoma
Prognostic impact of additional HPV-typing in p16-stratified advanced oropharyngeal squamous cell carcinoma Open
Background p16 is considered as surrogate marker for the identification of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCCs)
View article: The use of algeness in the face and neck: a safe, alternative filler for cosmetics and reconstruction
The use of algeness in the face and neck: a safe, alternative filler for cosmetics and reconstruction Open
Compared to other injectables, it exhibits good tolerability, excellent persistence, negligible immunological reaction, biocompatibility and maximal safety-all properties combined with immediate volume restoration and predictable outcomes.…
View article: Neurotoxin injection in benign submandibular gland hypertrophy: A first choice treatment
Neurotoxin injection in benign submandibular gland hypertrophy: A first choice treatment Open
Background Various benign clinical entities with a symptomatology of hypertrophic submandibular glands like sialadenitis, sialadenosis, sialolithiasis, or an ageing neck have been described. Botulinum toxin type A is an elegant tool in the…
View article: Benefit of postoperative radiotherapy for early tumors with single ipsilateral lymph node metastasis
Benefit of postoperative radiotherapy for early tumors with single ipsilateral lymph node metastasis Open
Objectives/Hypothesis Indication for postoperative radiotherapy in patients with locally circumscribed tumors (pT1–pT2) and a single ipsilateral lymph node metastasis (pN1) is debatable. The aim of this study was to evaluate the oncologica…
View article: Long-Term Stability and Functional Outcome of an Active Middle Ear Implant Regarding Different Coupling Sites
Long-Term Stability and Functional Outcome of an Active Middle Ear Implant Regarding Different Coupling Sites Open
Objectives: Indication and implantation of active middle ear implants (AMEI) are well established. Choice of the coupling site depends from the individual anatomical situation. Long-term stability of different coupling sites in terms of fu…
View article: Molecular Characterization of Lipoaspirates Used in Regenerative Head and Neck Surgery
Molecular Characterization of Lipoaspirates Used in Regenerative Head and Neck Surgery Open
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View article: A High-Throughput Method as a Diagnostic Tool for HIV Detection in Patient-Specific Induced Pluripotent Stem Cells Generated by Different Reprogramming Methods
A High-Throughput Method as a Diagnostic Tool for HIV Detection in Patient-Specific Induced Pluripotent Stem Cells Generated by Different Reprogramming Methods Open
Induced pluripotent stem cells (iPSCs) provide a unique opportunity for generation of patient-specific cells for use in translational purposes. We aimed to compare iPSCs generated by different reprogramming methods regarding their reprogra…
View article: MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer
MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer Open
Background MicroRNAs (miRNA) recently evolved as potential cancer biomarkers. Therefore, the aim of the present study was to evaluate the prognostic impact of eight miRNAs connected to oral squamous cell carcinoma (OSCC). Method Expression…
View article: Reconstruction of the skull base in spontaneous rhinoliquorrhea
Reconstruction of the skull base in spontaneous rhinoliquorrhea Open
Objective/Hypothesis: Spontaneous rhinoliquorrhea often occurs due to defects of the skull base. It is often misinterpreted as rhinitis and is surgically the most difficult rhinoliquorrhea entity to close. Methods: We conducted a retrospec…
View article: Radiation‐induced sensitivity of tissue‐resident mesenchymal stem cells in the head and neck region
Radiation‐induced sensitivity of tissue‐resident mesenchymal stem cells in the head and neck region Open
Background Tissue‐resident mesenchymal stem cells (MSCs) possess the ability to migrate to areas of inflammation and promote the regeneration of damaged tissue. However, it remains unclear how radiation influences this capacity of MSC in t…
View article: Postoperative radiotherapy in patients with early tumors (pT1 – 2) and a single ipsilateral lymph node metastasis (pN1)
Postoperative radiotherapy in patients with early tumors (pT1 – 2) and a single ipsilateral lymph node metastasis (pN1) Open
Indication for postoperative radiotherapy in patients with early tumors (pT1 – 2) and a single ipsilateral lymph node metastasis (pN1) is still debated. Aim of this study was to evaluate the oncologic outcome for postoperative radiotherapy…
View article: MicroRNA-182 and KTN1: Potential Biomarkers for Prognosis in Oral Squamous Cell Carcinoma
MicroRNA-182 and KTN1: Potential Biomarkers for Prognosis in Oral Squamous Cell Carcinoma Open
MicroRNA (miRNA) recently evolved as potential cancer biomarkers, in particular miRNA-182 is known to hold an oncogenic function in liver, lung and breast cancer. However, to our knowledge the prognostic impact of miRNA-182 in oral squamou…
View article: EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers
EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers Open
Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal t…
View article: Effect of ionizing radiation of MSCs of the head and neck region
Effect of ionizing radiation of MSCs of the head and neck region Open
Adulte mesenchymale Stammzellen (MSCs) der Kopf-Hals-Region spielen eine wichtige regulatorische Rolle bei der lokalen Wundheilung und bei Inflammation wie beispielsweise unter einer Bestrahlungstherapie bei Kopf-Hals-Karzinompatienten. Ob…
View article: Transoral laser microsurgery for primary subglottic carcinoma – a therapeutic option?
Transoral laser microsurgery for primary subglottic carcinoma – a therapeutic option? Open
With about 2% primary subglottic carcinoma are rare laryngeal malignancies. Consequently, only few studies describe the oncologic outcome of different treatment strategies. Transoral laser microsurgery is established for the treatment of g…
View article: The cannabinoid receptor 2 agonist JWH-133 is capable of revoking changes in cochlear microcirculation induced by lipopolysaccharide
The cannabinoid receptor 2 agonist JWH-133 is capable of revoking changes in cochlear microcirculation induced by lipopolysaccharide Open
Cannabinoid receptors (CBR) are divided into two subclasses. The subtype 2 mediates several antiinflammatory effects that make it a valid candidate as an otoprotective agent. We therefore investigated the ability of JWH-133, a CBR-2 agonis…