Jakob Triebel
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View article: Cardiovascular Safety of VIAN‐c4551, an Antiangiogenic Peptide Derived From Vasoinhibin
Cardiovascular Safety of VIAN‐c4551, an Antiangiogenic Peptide Derived From Vasoinhibin Open
Vasoinhibin is a potent antiangiogenic protein that blocks the activation of endothelial nitric oxide synthase (eNOS) in response to vascular endothelial growth factor, bradykinin, and acetylcholine (ACh). In this regard, VIAN‐c4551, a new…
View article: Topical ophthalmic administration of the antiangiogenic peptide VIAN-c4551 protects against experimental diabetic macular edema
Topical ophthalmic administration of the antiangiogenic peptide VIAN-c4551 protects against experimental diabetic macular edema Open
Increased angiogenesis and vascular permeability are hallmarks of microvascular retinal diseases such as diabetic retinopathy and diabetic macular edema (DME). Periodic intravitreal injections of inhibitors of the vascular endothelial grow…
View article: Relationships Between H2S and OT/OTR Systems in Preeclampsia
Relationships Between H2S and OT/OTR Systems in Preeclampsia Open
Pre-eclampsia (PE) is a hypertensive pregnancy complication. Oxidative stress is hypothesized to contribute to the pathophysiology of PE. Both the hydrogen sulfide (H2S) and oxytocin (OT) systems might play a role in the pathophysiology of…
View article: The role of the H<sub>2</sub>S and OT systems in pre-eclampsia
The role of the H<sub>2</sub>S and OT systems in pre-eclampsia Open
Pre-eclampsia (PE) is a hypertensive pregnancy complication. Oxidative stress is hypothesized to contribute to the pathophysiology of PE. Both the hydrogen sulfide (H 2 S) and oxytocin (OT) systems might play a role in the pathophysiology …
View article: The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability
The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability Open
Introduction Cancer cells drive the increase in vascular permeability mediating tumor cell extravasation and metastatic seeding. VIAN-c4551, an antiangiogenic peptide analog of vasoinhibin, inhibits the growth and vascularization of melano…
View article: Call for Submissions: Prolactin in cardiovascular disease, prolactin reference ranges, and clinical significance of hypo- and hyperprolactinemia
Call for Submissions: Prolactin in cardiovascular disease, prolactin reference ranges, and clinical significance of hypo- and hyperprolactinemia Open
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View article: Vasoinhibin is Generated by the Renin-angiotensin System
Vasoinhibin is Generated by the Renin-angiotensin System Open
Vasoinhibin is a fragment of the hormone prolactin (PRL) that inhibits angiogenesis, vasopermeability, and vasodilation. Cathepsin D (CTSD) cleaves the N-terminal of PRL to generate vasoinhibin in the retina of neonate mice as revealed by …
View article: The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability
The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability Open
Introduction Cancer cells drive the increase in vascular permeability mediating tumor cell extravasation and metastatic seeding. VIAN-c4551, an antiangiogenic peptide analog of vasoinhibin, inhibits the growth and vascularization of melano…
View article: Vasoinhibin is Generated by the Renin-Angiotensin System
Vasoinhibin is Generated by the Renin-Angiotensin System Open
Vasoinhibin is a fragment of the hormone prolactin (PRL) that inhibits angiogenesis, vasopermeability, and vasodilation. Cathepsin D (CTSD) cleaves the N-teminal of PRL to generate vasoinhibin in the retina of neonate mice as revealed by t…
View article: Immunometric and functional measurement of endogenous vasoinhibin in human sera
Immunometric and functional measurement of endogenous vasoinhibin in human sera Open
Introduction Circulating levels of the antiangiogenic protein vasoinhibin, a fragment of prolactin, are of interest in vasoproliferative retinopathies, preeclampsia, and peripartum cardiomyopathy; however, it is difficult to determine the …
View article: Vasoinhibin’s Apoptotic, Inflammatory, and Fibrinolytic Actions Are in a Motif Different From Its Antiangiogenic HGR Motif
Vasoinhibin’s Apoptotic, Inflammatory, and Fibrinolytic Actions Are in a Motif Different From Its Antiangiogenic HGR Motif Open
Vasoinhibin, a proteolytic fragment of the hormone prolactin, inhibits blood vessel growth (angiogenesis) and permeability, stimulates the apoptosis and inflammation of endothelial cells, and promotes fibrinolysis. The antiangiogenic and a…
View article: OR2806 Levosulpiride-Induced Hyperprolactinemia For The Treatment Of Diabetic Macular Edema: A Phase 2 Pilot Clinical Trial
OR2806 Levosulpiride-Induced Hyperprolactinemia For The Treatment Of Diabetic Macular Edema: A Phase 2 Pilot Clinical Trial Open
Disclosure: C. Clapp: None. C.D. Núñez-Amaro: None. M. López: None. E. Adán-Castro: None. M. Robles Osorio: None. R. García-Franco: None. M. García-Roa: None. Y. Villalpando: None. P. Ramírez-Neria: None. N. Pineiro: None. J.F. Rubio-Mijan…
View article: Levosulpiride for the treatment of diabetic macular oedema: a phase 2 randomized clinical trial
Levosulpiride for the treatment of diabetic macular oedema: a phase 2 randomized clinical trial Open
View article: The apoptotic, inflammatory, and fibrinolytic actions of vasoinhibin are in a motif different from its antiangiogenic HGR motif
The apoptotic, inflammatory, and fibrinolytic actions of vasoinhibin are in a motif different from its antiangiogenic HGR motif Open
Vasoinhibin is a proteolytic fragment of the hormone prolactin that inhibits blood vessel growth (angiogenesis) and permeability, stimulates the apoptosis and inflammation of endothelial cells and promotes fibrinolysis. The antiangiogenic …
View article: Immune activating and inhibiting effects of calcitriol on γδ T cells and NK cells
Immune activating and inhibiting effects of calcitriol on γδ T cells and NK cells Open
The immune modulatory effects of vitamin D and the impact of vitamin D deficiency on various diseases are a subject of current scientific research. However, there are few data directly linking vitamin D to hard endpoints in clinical studie…
View article: Prolactin and vasoinhibin are endogenous players in diabetic retinopathy revisited
Prolactin and vasoinhibin are endogenous players in diabetic retinopathy revisited Open
Diabetic retinopathy (DR) and diabetic macular edema (DME) are major causes for visual loss in adults. Nearly half of the world’s population with diabetes has some degree of DR, and DME is a major cause of visual impairment in these patien…
View article: New horizons in specific hormone proteolysis
New horizons in specific hormone proteolysis Open
Proteolysis of protein hormones is primarily acknowledged in the context of breakdown and metabolic clearance by hepatorenal elimination. However, less explored is the specific proteolytic processing of large protein hormones, for which ca…
View article: Complement Proteins C5/C5a, Cathepsin D and Prolactin in Chondrocytes: A Possible Crosstalk in the Pathogenesis of Osteoarthritis
Complement Proteins C5/C5a, Cathepsin D and Prolactin in Chondrocytes: A Possible Crosstalk in the Pathogenesis of Osteoarthritis Open
Introduction: Both increased activity of the complement system (CS) and the role of the pituitary hormone prolactin (PRL) are implicated in osteoarthritis (OA) pathogenesis. Besides, Cathepsin D (CatD) activity is increased in the context …
View article: A comparative phylogenetic analysis of prolactin cleavage sites for the generation of vasoinhibin in vertebrates
A comparative phylogenetic analysis of prolactin cleavage sites for the generation of vasoinhibin in vertebrates Open
Vasoinhibin is a pleiotropic protein hormone with endocrine, autocrine, and paracrine effects on blood vessel growth, permeability, and dilation, and a role in several human diseases. It is generated by proteolytic cleavage of the pituitar…
View article: Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin
Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin Open
Hormonal factors affecting the vascular adaptions of the uteroplacental unit in noncomplicated and complicated pregnancies are of interest. Here, 4 human placentas from women with and without preeclampsia (PE) were investigated for the pre…
View article: Plasmin generates vasoinhibin-like peptides by cleaving prolactin and placental lactogen
Plasmin generates vasoinhibin-like peptides by cleaving prolactin and placental lactogen Open
Vasoinhibin is an antiangiogenic, profibrinolytic peptide generated by the proteolytic cleavage of the pituitary hormone prolactin by cathepsin D, matrix metalloproteinases, and bone morphogenetic protein-1. Vasoinhibin can also be generat…
View article: SUPPLEMENTARY DATA FOR "HIGH RESOLUTION CONTINUOUS ELUTION ELECTROPHORESIS FOR THE EVALUATION OF LOW ABUNDANCE SERUM PROTEINS"
SUPPLEMENTARY DATA FOR "HIGH RESOLUTION CONTINUOUS ELUTION ELECTROPHORESIS FOR THE EVALUATION OF LOW ABUNDANCE SERUM PROTEINS" Open
The dataset contains high resolution source image files (TIF-format) of SDS-PAGE gels containing isolated serum proteins eluted from a continuous electrophoresis system.
View article: Thrombin Cleaves Prolactin Into a Potent 5.6-kDa Vasoinhibin: Implication for Tissue Repair
Thrombin Cleaves Prolactin Into a Potent 5.6-kDa Vasoinhibin: Implication for Tissue Repair Open
Vasoinhibin is an endogenous prolactin (PRL) fragment with profibrinolytic, antivasopermeability, and antiangiogenic effects. The fact that blood clotting, vascular permeability, and angiogenesis are functionally linked during the wound-he…
View article: The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide
The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide Open
View article: Development of Vasoinhibin-Specific Monoclonal Antibodies
Development of Vasoinhibin-Specific Monoclonal Antibodies Open
Vasoinhibin is a protein hormone with antiangiogenic, antivasodilatatory, and antivasopermeability effects generated by the proteolytic cleavage of prolactin. The discovery of its role in diabetic retinopathy and peripartum cardiomyopathy …
View article: Levosulpiride Increases the Levels of Prolactin and Antiangiogenic Vasoinhibin in the Vitreous of Patients with Proliferative Diabetic Retinopathy
Levosulpiride Increases the Levels of Prolactin and Antiangiogenic Vasoinhibin in the Vitreous of Patients with Proliferative Diabetic Retinopathy Open
These findings support the potential therapeutic benefit of levosulpiride against vision loss in diabetes.
View article: A Dysregulation of the Prolactin/Vasoinhibin Axis Appears to Contribute to Preeclampsia
A Dysregulation of the Prolactin/Vasoinhibin Axis Appears to Contribute to Preeclampsia Open
Preeclampsia is a hypertensive disorder affecting 3-5% of all pregnancies. The only curative treatment is delivery of the placenta and the pathophysiology is poorly understood. Studies have demonstrated altered levels of antiangiogenic fac…
View article: High Resolution Images of "Matrix Metalloproteases and Cathepsin D in Human Serum do not Cleave Prolactin to Generate Vasoinhibin"
High Resolution Images of "Matrix Metalloproteases and Cathepsin D in Human Serum do not Cleave Prolactin to Generate Vasoinhibin" Open
The dataset contains high resolution image files of Western Blots in JPG and TIFF-file format.
View article: Improving Immunotherapy Against B-Cell Malignancies Using γδ T-Cell–specific Stimulation and Therapeutic Monoclonal Antibodies
Improving Immunotherapy Against B-Cell Malignancies Using γδ T-Cell–specific Stimulation and Therapeutic Monoclonal Antibodies Open
Tumor antigen–targeting monoclonal antibodies (mAbs) are an important element of current cancer therapies. Some of these therapeutic mAbs enable antibody-dependent cell mediated cytotoxicity (ADCC) against tumor cells. However, cancer-rela…
View article: Analysing Point Mutations in Protein Cleavage Sites by Using Enzyme Specificity Matrices
Analysing Point Mutations in Protein Cleavage Sites by Using Enzyme Specificity Matrices Open
OPINION article Front. Endocrinol., 03 May 2019Sec. Systems Endocrinology Volume 10 - 2019 | https://doi.org/10.3389/fendo.2019.00267