Jakub Cieszkowski
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View article: Hydrogen Sulfide-Releasing Indomethacin-Derivative (ATB-344) Prevents the Development of Oxidative Gastric Mucosal Injuries
Hydrogen Sulfide-Releasing Indomethacin-Derivative (ATB-344) Prevents the Development of Oxidative Gastric Mucosal Injuries Open
Hydrogen sulfide (H2S) emerged recently as an anti-oxidative signaling molecule that contributes to gastrointestinal (GI) mucosal defense and repair. Indomethacin belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs) and i…
View article: Administration of Warfarin Inhibits the Development of Cerulein-Induced Edematous Acute Pancreatitis in Rats
Administration of Warfarin Inhibits the Development of Cerulein-Induced Edematous Acute Pancreatitis in Rats Open
Acute pancreatitis (AP) is a severe disease with high morbidity and mortality in which inflammation and coagulation play crucial roles. The development of inflammation leads to vascular injury, endothelium and leukocytes stimulation, and a…
View article: Healing Effect of Warfarin in the Course of Cerulein-Induced Acute Pancreatitis
Healing Effect of Warfarin in the Course of Cerulein-Induced Acute Pancreatitis Open
Acute pancreatitis (AP) is the most common gastrointestinal disease leading to hospitalizations. The development of AP leads to damage of the pancreatic microcirculation with a cascade of subsequent events resulting, among others, in coagu…
View article: Mitochondria-targeted hydrogen sulfide donors versus acute oxidative gastric mucosal injury
Mitochondria-targeted hydrogen sulfide donors versus acute oxidative gastric mucosal injury Open
Hydrogen sulfide (H2S) as a gaseous molecule prevents gastrointestinal (GI)-tract against various injuries. This study aimed to evaluate for the first time the detailed molecular mechanism of mitochondria-targeting H2S-prodrugs, AP39 and R…
View article: Microbiome Profile and Molecular Pathways Alterations in Gastrointestinal Tract by Hydrogen Sulfide-Releasing Nonsteroidal Anti-Inflammatory Drug (ATB-352): Insight into Possible Safer Polypharmacy
Microbiome Profile and Molecular Pathways Alterations in Gastrointestinal Tract by Hydrogen Sulfide-Releasing Nonsteroidal Anti-Inflammatory Drug (ATB-352): Insight into Possible Safer Polypharmacy Open
Aims: Nonsteroidal anti-inflammatory drugs, including ketoprofen, induce adverse effects within the gastrointestinal (GI)-tract. Hydrogen sulfide (H2S) is an antioxidative gaseous mediator contributing to GI-protection. We aimed to evaluat…
View article: Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage Open
Metal-based carbon monoxide (CO)-releasing molecules have been shown to exert anti-inflammatory and anti-oxidative properties maintaining gastric mucosal integrity. We are interested in further development of metal-free CO-based therapeuti…
View article: Pretreatment with Warfarin Attenuates the Development of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats
Pretreatment with Warfarin Attenuates the Development of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats Open
In acute pancreatitis (AP), pancreatic damage leads to local vascular injury, manifesting as endothelial damage and activation, increased vascular permeability, leukocyte rolling, sticking and transmigration to pancreatic tissue as well as…
View article: Correction: Warzecha, Z., et al. Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats. Int. J. Mol. Sci. 2017, 18, 882
Correction: Warzecha, Z., et al. Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats. Int. J. Mol. Sci. 2017, 18, 882 Open
We would like to submit this correction to our published paper [...]
View article: Correction: Warzecha, Z. et al. Protective Effect of Pretreatment with Acenocoumarol in Cerulein-Induced Acute Pancreatitis. Int. J. Mol. Sci. 2016, 17, 1709
Correction: Warzecha, Z. et al. Protective Effect of Pretreatment with Acenocoumarol in Cerulein-Induced Acute Pancreatitis. Int. J. Mol. Sci. 2016, 17, 1709 Open
We would like to submit the correction to our published paper [...]
View article: Treatment with Obestatin—A Ghrelin Gene-Encoded Peptide—Reduces the Severity of Experimental Colitis Evoked by Trinitrobenzene Sulfonic Acid
Treatment with Obestatin—A Ghrelin Gene-Encoded Peptide—Reduces the Severity of Experimental Colitis Evoked by Trinitrobenzene Sulfonic Acid Open
Obestatin is a 23-amino acid peptide derived from proghrelin, a common prohormone for ghrelin and obestatin. Previous studies showed that obestatin exhibited some protective and therapeutic effects in the gut. The aim of our presented stud…
View article: Essential Role of Growth Hormone and IGF-1 in Therapeutic Effect of Ghrelin in the Course of Acetic Acid-Induced Colitis
Essential Role of Growth Hormone and IGF-1 in Therapeutic Effect of Ghrelin in the Course of Acetic Acid-Induced Colitis Open
Previous studies have shown that ghrelin exhibits a protective and therapeutic effect in the gut. The aim of the present study was to examine whether administration of ghrelin affects the course of acetic acid-induced colitis and to determ…
View article: Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats
Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats Open
Intravascular activation of coagulation is observed in acute pancreatitis and is related to the severity of this inflammation. The aim of our study was to evaluate the impact of acenocoumarol therapy on the course of acute pancreatitis ind…
View article: Protective Effect of Pretreatment with Acenocoumarol in Cerulein-Induced Acute Pancreatitis
Protective Effect of Pretreatment with Acenocoumarol in Cerulein-Induced Acute Pancreatitis Open
Coagulation is recognized as a key player in inflammatory and autoimmune diseases. The aim of the current research was to examine the effect of pretreatment with acenocoumarol on the development of acute pancreatitis (AP) evoked by cerulei…
View article: Exogenous Ghrelin Accelerates the Healing of Acetic Acid-Induced Colitis in Rats
Exogenous Ghrelin Accelerates the Healing of Acetic Acid-Induced Colitis in Rats Open
Previous studies have shown that ghrelin reduces colonic inflammation induced by trinitrobenzene sulfonic acid and dextran sodium sulfate. In the present study we determined the effect of treatment with ghrelin on the course of acetic acid…
View article: Pretreatment with obestatin inhibits the development of acetic acid-induced colitis in rats
Pretreatment with obestatin inhibits the development of acetic acid-induced colitis in rats Open
Pretreatment with obestatin exhibited a protective effect in the colon, leading to a reduction of colonic damage in acetic acid-induced colitis. This effect was associated with an improvement of mucosal blood flow, an increase in mucosal c…
View article: Synergic Interaction of Rifaximin and Mutaflor (<i>Escherichia coli</i>Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats
Synergic Interaction of Rifaximin and Mutaflor (<i>Escherichia coli</i>Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats Open
Background . Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and…
View article: Obestatin Accelerates the Healing of Acetic Acid‐Induced Colitis in Rats
Obestatin Accelerates the Healing of Acetic Acid‐Induced Colitis in Rats Open
Obestatin, a 23‐amino acid peptide derived from the proghrelin, has been shown to exhibit some protective and therapeutic effects in the gut. The aim of present study was to determine the effect of obestatin administration on the course of…
View article: Therapeutic Effect of Obestatin in the Course of Cerulein-Induced Acute Pancreatitis
Therapeutic Effect of Obestatin in the Course of Cerulein-Induced Acute Pancreatitis Open
Treatment with exogenous obestatin reduces severity of AP and accelerates pancreatic recovery.
View article: The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats
The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats Open
Ghrelin has protective and therapeutic effects in the gut. The aim of present studies was to investigate the effect of treatment with ghrelin on the development of colitis evoked by dextran sodium sulfate (DSS). Methods. Studies have been …
View article: The Beginnings of Pancreatology as a Field of Experimental and Clinical Medicine
The Beginnings of Pancreatology as a Field of Experimental and Clinical Medicine Open
This review presents the history of discoveries concerning the pancreas. In antiquity and the Middle Ages knowledge about the anatomy of the pancreas was very limited and its function was completely unknown. Significant progress was first …