Jakub Gruszczyk
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View article: Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds
Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds Open
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor belonging to the bHLH/PAS protein family and responding to hundreds of natural and chemical substances. It is primarily involved in the defense against chemical…
View article: Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex
Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex Open
Summary Living organisms have developed protein sensors helping them to adapt to their environment 1 . The aryl hydrocarbon receptor (AHR) is an emblematic member of this class of proteins, and a ligand-dependent transcription factor that …
View article: Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures
Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures Open
Significance Many environmental pollutants act as endocrine disruptors that interfere with normal endocrine regulation and promote adverse effects in humans. As a major target of xenobiotics, the pregnane X receptor (PXR) is known to play …
View article: Antibodies to Plasmodium vivax reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations living in low malaria transmission regions of Brazil and Thailand
Antibodies to Plasmodium vivax reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations living in low malaria transmission regions of Brazil and Thailand Open
Our results indicate that PvRBP2b warrants further preclinical development as a blood-stage vaccine candidate against P. vivax. Total IgG responses to PvRBPs were also shown to be promising immunological markers of exposure to P. vivax inf…
View article: Complement Receptor 1 availability on red blood cell surface modulates Plasmodium vivax invasion of human reticulocytes
Complement Receptor 1 availability on red blood cell surface modulates Plasmodium vivax invasion of human reticulocytes Open
Plasmodium vivax parasites preferentially invade reticulocyte cells in a multistep process that is still poorly understood. In this study, we used ex vivo invasion assays and population genetic analyses to investigate the involvement of co…
View article: Evolutionary history of human <i>Plasmodium vivax</i> revealed by genome-wide analyses of related ape parasites
Evolutionary history of human <i>Plasmodium vivax</i> revealed by genome-wide analyses of related ape parasites Open
Significance Chimpanzees, bonobos, and gorillas harbor close relatives of human Plasmodium vivax , but current knowledge of these parasites is limited to a small number of gene fragments derived almost exclusively from mitochondrial DNA. W…
View article: Transferrin receptor 1 is a reticulocyte-specific receptor for <i>Plasmodium vivax</i>
Transferrin receptor 1 is a reticulocyte-specific receptor for <i>Plasmodium vivax</i> Open
Vivax malaria host receptor Human malaria is caused by half a dozen species of Plasmodium protozoan parasites, each with distinctive biology. P. vivax , which causes relapsing malaria, specifically parasitizes immature red blood cells call…
View article: Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development
Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development Open
The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relations…
View article: Author response: Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development
Author response: Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract The study of antigenic targets of naturally-acquired immunit…
View article: MOESM1 of Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand
MOESM1 of Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand Open
Additional file 1. All antibody data generated, and epidemiological data analysed, for the current study. Antibody data is given in Relative Antibody Units (not log transformed).
View article: Plasmodium vivax Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children
Plasmodium vivax Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children Open
These results demonstrate a diversity of erythrocyte-binding phenotypes of PvRBPs, indicating binding to both reticulocyte-specific and normocyte-specific ligands. Our findings provide further insights into the naturally acquired immunity …