Jakub Sýs
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View article: Droplet microfluidic hydrogen/deuterium exchange for investigating protein dynamics with millisecond precision
Droplet microfluidic hydrogen/deuterium exchange for investigating protein dynamics with millisecond precision Open
Hydrogen/deuterium exchange (HDX) methods for studying protein dynamics would benefit from millisecond-scale incubations to probe intrinsically disordered proteins, highly dynamic regions and conformation changes. Here we investigate dropl…
View article: A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein
A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein Open
For most retroviruses, including HIV, association with the plasma membrane (PM) promotes the assembly of immature particles, which occurs simultaneously with budding and maturation. In these viruses, maturation is initiated by oligomerizat…
View article: Author response: A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein
Author response: A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein Open
Full text Figures and data Peer review Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract For most retroviruses, incl…
View article: Deciphering the Allosteric Regulation of Mycobacterial Inosine-5′-Monophosphate Dehydrogenase
Deciphering the Allosteric Regulation of Mycobacterial Inosine-5′-Monophosphate Dehydrogenase Open
Allosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine nucleotides. However, the precise molecular mechanism of IMPDH regulat…
View article: A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein
A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein Open
For most retroviruses, including HIV, association with the plasma membrane (PM) promotes the assembly of immature particles, which occurs simultaneously with budding and maturation. In these viruses, maturation is initiated by oligomerizat…
View article: Interaction Interface of Mason-Pfizer Monkey Virus Matrix and Envelope Proteins
Interaction Interface of Mason-Pfizer Monkey Virus Matrix and Envelope Proteins Open
By a combination of nuclear magnetic resonance (NMR) and mass spectroscopy of cross-linked peptides, we show that in contrast to human immunodeficiency virus type 1 (HIV-1), the C-terminal residues of the unstructured cytoplasmic tail of M…
View article: Correction: Differences and commonalities in plasma membrane recruitment of the two morphogenetically distinct retroviruses HIV-1 and MMTV
Correction: Differences and commonalities in plasma membrane recruitment of the two morphogenetically distinct retroviruses HIV-1 and MMTV Open
VOLUME 295 (2020) PAGES 8819–8833 There were several typographical errors. In the next to last sentence under “CG-MD simulations of HIV-1 and MMTV MA-membrane interaction,” “a chain in the 4ZV5 structure in the Protein Data Bank” should re…