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View article: 37Integrative multi-omic characterization of the immune landscape in renal cell carcinoma
37Integrative multi-omic characterization of the immune landscape in renal cell carcinoma Open
Background Renal Cell Carcinoma (RCC) has been characterized as being amongst the most immune infiltrated solid tumors with a highly heterogenous immune landscape. Within spatially organized cellular networks (CNs) of the tumor immune micr…
View article: MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma
MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma Open
View article: Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality
Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality Open
View article: Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer
Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer Open
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer that often displays resistance to conventional cancer therapies, including chemotherapy and radiation therapy. Targeted treatments, including immunotherapies …
View article: Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes
Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes Open
There is a pressing need to improve risk stratification and treatment selection for HPV-negative head and neck squamous cell carcinoma (HNSCC) due to the adverse side effects of treatment. One of the most important prognostic features is l…
View article: Pan-cancer<i>N</i>-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers
Pan-cancer<i>N</i>-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers Open
SUMMARY Cell surface proteins offer significant cancer therapeutic potential attributable to their accessible membrane localization and central role in cellular signaling. Despite this, their promise remains largely untapped due to the tec…
View article: Understanding and overcoming innate and acquired MAPK-inhibition resistance in anaplastic thyroid cancer
Understanding and overcoming innate and acquired MAPK-inhibition resistance in anaplastic thyroid cancer Open
Anaplastic thyroid cancer (ATC) is one of the most lethal human cancers, with some patients succumbing to the disease within weeks of diagnosis. Although a subset of patients with ATC with BRAF V600E mutation respond to the monomeric type …
View article: SPECT/CT imaging of EGFR-positive head and neck squamous cell carcinoma patient-derived xenografts with 203Pb-PSC-panitumumab in NRG mice
SPECT/CT imaging of EGFR-positive head and neck squamous cell carcinoma patient-derived xenografts with 203Pb-PSC-panitumumab in NRG mice Open
Panitumumab was successfully and reproducibly labelled with 203Pb in high radiochemical purity using the chelator PSC-NCS. 203Pb-PSC-panitumumab was specifically accumulated and retained in EGFR + tumours in NRG mice …
View article: PRMT1 inhibition perturbs RNA metabolism and induces DNA damage in clear cell renal cell carcinoma
PRMT1 inhibition perturbs RNA metabolism and induces DNA damage in clear cell renal cell carcinoma Open
View article: Data from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Data from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
Epidermal growth factor receptor (EGFR) is frequently amplified or mutated in non–small cell lung cancer (NSCLC). Although Fer protein-tyrosine kinase signals downstream of EGFR, its role in NSCLC tumor progression has not been reported. H…
View article: Supplementary Figure 4 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Figure 4 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 120K, Fer promotes migration and invasion of A549 cells.
View article: Data from Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis
Data from Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis Open
Triple-negative breast cancers (TNBCs) are highly aggressive cancers that lack targeted therapies. However, EGFR is frequently activated in a subset of TNBCs and represents a viable clinical target. Because the endocytic adaptor protein En…
View article: Supplementary Figure 3 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Figure 3 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 196K, Fer promotes wound healing migration of H1299 cells.
View article: Supplementary Movie 1 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Movie 1 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
MP4 file - 307K
View article: Data from Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis
Data from Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis Open
Triple-negative breast cancers (TNBCs) are highly aggressive cancers that lack targeted therapies. However, EGFR is frequently activated in a subset of TNBCs and represents a viable clinical target. Because the endocytic adaptor protein En…
View article: Supplementary Methods from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Methods from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 87K
View article: Supplementary Figure 4 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Figure 4 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 120K, Fer promotes migration and invasion of A549 cells.
View article: Supplementary Methods from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Methods from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 87K
View article: Data from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Data from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
Epidermal growth factor receptor (EGFR) is frequently amplified or mutated in non–small cell lung cancer (NSCLC). Although Fer protein-tyrosine kinase signals downstream of EGFR, its role in NSCLC tumor progression has not been reported. H…
View article: Supplementary Movie 1 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Movie 1 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
MP4 file - 307K
View article: Supplementary Figures S1-7 from Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis
Supplementary Figures S1-7 from Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis Open
Supplementary Figures S1-7. Supplementary Figure S1. Endo II mRNA expression profiling in breast cancer cell lines arranged by molecular subtypes. Supplementary Figure S2. Endo II silencing causes defects in EGFR internalization. Supplemen…
View article: PRMT1 is a critical dependency in clear cell renal cell carcinoma through its role in post-transcriptional regulation of DNA damage response genes
PRMT1 is a critical dependency in clear cell renal cell carcinoma through its role in post-transcriptional regulation of DNA damage response genes Open
Biallelic inactivation of the Von Hippel-Lindau ( VHL ) tumor suppressor gene occurs in almost all cases of clear cell renal cell carcinoma (ccRCC) and leads to disrupted oxygen sensing and the upregulation of hypoxia-related genetic progr…
View article: Supplementary Figure 3 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Figure 3 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 196K, Fer promotes wound healing migration of H1299 cells.
View article: Supplementary Figure 2 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Figure 2 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 80K, Vav2 domains and regulation via tyrosine phosphorylation.
View article: Supplementary Figure 1 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Figure 1 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 267K, Specificity of Fer IHC staining in NSCLC.
View article: Supplementary Figure 1 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Figure 1 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 267K, Specificity of Fer IHC staining in NSCLC.
View article: Supplementary Figure 2 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Supplementary Figure 2 from Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis Open
PDF file - 80K, Vav2 domains and regulation via tyrosine phosphorylation.
View article: Supplementary Figures S1-7 from Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis
Supplementary Figures S1-7 from Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis Open
Supplementary Figures S1-7. Supplementary Figure S1. Endo II mRNA expression profiling in breast cancer cell lines arranged by molecular subtypes. Supplementary Figure S2. Endo II silencing causes defects in EGFR internalization. Supplemen…
View article: Supplementary Figure 2 from PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma
Supplementary Figure 2 from PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma Open
Supplementary Figure 2
View article: Supplementary Data from PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma
Supplementary Data from PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma Open
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