James A. Blumenthal
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View article: Racial differences in the association between heart rate variability and left ventricular mass
Racial differences in the association between heart rate variability and left ventricular mass Open
NEW FINDINGS: What is the central question of this study? Decreased heart rate variability (HRV) is associated with increased cardiovascular disease (CVD) risk, including greater left ventricular mass (LVM). Despite their enhanced CVD risk…
View article: Race and sex differences in cardiovascular α-adrenergic and β-adrenergic receptor responsiveness in men and women with high blood pressure
Race and sex differences in cardiovascular α-adrenergic and β-adrenergic receptor responsiveness in men and women with high blood pressure Open
OBJECTIVE: Hypertension is associated with unfavorable changes in adrenergic receptor responsiveness, but the relationship of race and sex to adrenergic receptor responsiveness in the development of cardiovascular disease is unclear. This …
View article: The Effects of Ambulatory Blood Pressure Monitoring on Sleep Quality in Men and Women With Hypertension: Dipper vs. Nondipper and Race Differences
The Effects of Ambulatory Blood Pressure Monitoring on Sleep Quality in Men and Women With Hypertension: Dipper vs. Nondipper and Race Differences Open
BACKGROUND: The nondipping circadian blood pressure (BP) profile is associated with both poor sleep quality and increased cardiovascular risk. The present study aimed to clarify the potential confounding effects of 24-hour ambulatory blood…
View article: Infant Outcomes in Hypertensive Women: Are there Moderating Effects of Prenatal Care and Race/Ethnicity?
Infant Outcomes in Hypertensive Women: Are there Moderating Effects of Prenatal Care and Race/Ethnicity? Open
View article: Depression and Adverse Cardiovascular Disease Outcomes: Cause or Consequence?
Depression and Adverse Cardiovascular Disease Outcomes: Cause or Consequence? Open
It is well established that depression and cardiovascular disease (CVD) commonly accompany each other.[1] In patients with existing CVD, depression is associated with worse disease outcomes.[2] However, the potential existence of a causal …
View article: Integrating depression and acute coronary syndrome care in low resource hospitals in China: the I-CARE randomised clinical trial
Integrating depression and acute coronary syndrome care in low resource hospitals in China: the I-CARE randomised clinical trial Open
View article: Depressive symptoms are associated with clinical outcomes in heart failure with reduced ejection fraction
Depressive symptoms are associated with clinical outcomes in heart failure with reduced ejection fraction Open
Aims The objective of this study was to examine associations between elevated depressive symptoms and increased risk of adverse clinical events patients with heart failure and reduced ejection fraction (HFrEF), as well as the potential con…
View article: Cognitive behavior therapy for insomnia for untreated hypertension with comorbid insomnia disorder: The SLEEPRIGHT clinical trial
Cognitive behavior therapy for insomnia for untreated hypertension with comorbid insomnia disorder: The SLEEPRIGHT clinical trial Open
Insomnia and poor sleep are associated with an increased risk of developing cardiovascular disease (CVD) and its precursors, including hypertension. In 2022, the American Heart Association (AHA) added inadequate sleep to its list of health…
View article: Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest Trial (GOT ICE): A Randomized Clinical Trial Comparing Outcomes After Aortic Arch Surgery
Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest Trial (GOT ICE): A Randomized Clinical Trial Comparing Outcomes After Aortic Arch Surgery Open
BACKGROUND: Deep hypothermia has been the standard for hypothermic circulatory arrest (HCA) during aortic arch surgery. However, centers worldwide have shifted toward lesser hypothermia with antegrade cerebral perfusion. This has been supp…
View article: Association of Depression Symptoms and Biomarkers of Risk on Clinical Outcomes in HFrEF
Association of Depression Symptoms and Biomarkers of Risk on Clinical Outcomes in HFrEF Open
BACKGROUND Prior studies have demonstrated an association of depression with adverse clinical outcomes in patients with HFrEF, but the possible mechanisms responsible for the association are not unserstood. METHODS 142 men and women with H…
View article: Is exercise a viable therapy for anxiety? Systematic review of recent literature and critical analysis
Is exercise a viable therapy for anxiety? Systematic review of recent literature and critical analysis Open
View article: Effects of Lifestyle Modification on Psychosocial Function in Patients With Resistant Hypertension
Effects of Lifestyle Modification on Psychosocial Function in Patients With Resistant Hypertension Open
Purpose: In a secondary analysis of the TRIUMPH clinical trial, psychological outcomes in patients with resistant hypertension (RH) receiving a diet and exercise intervention delivered in a cardiac rehabilitation setting were compared with…
View article: Sleep Quality, Metabolic Function, Physical Activity, and Neurocognition Among Individuals with Resistant Hypertension
Sleep Quality, Metabolic Function, Physical Activity, and Neurocognition Among Individuals with Resistant Hypertension Open
Background: Resistant hypertension (RH) is a major risk factor for stroke, cognitive decline, and dementia. Sleep quality is increasingly suggested to play an important role linking RH to cognitive outcomes, although the mechanisms linking…
View article: Cardiology and lifestyle medicine
Cardiology and lifestyle medicine Open
Poor lifestyle habits, such as physical inactivity and poor diets, are highly prevalent within society and even more so among patients with chronic disease. The need to stem poor lifestyle habits has led to the development of a new field o…
View article: Exercise as a therapeutic modality for the prevention and treatment of depression
Exercise as a therapeutic modality for the prevention and treatment of depression Open
While maintaining an active lifestyle and engaging in regular exercise are known to promote cardiovascular (CV) health, increasing evidence has emerged to indicate that these lifestyle behaviors also can promote psychological health and we…
View article: Inflammation moderates the effects of lifestyle modification on neurocognition among individuals with resistant hypertension
Inflammation moderates the effects of lifestyle modification on neurocognition among individuals with resistant hypertension Open
Individuals with resistant hypertension (RH) have the greatest risk of cerebrovascular disease and cognitive impairment among individuals with hypertension. Elevated levels of pro‐inflammatory cytokines may represent a critical yet unexami…
View article: Exercise and Escitalopram in the Treatment of Anxiety in Patients with Coronary Heart Disease: One Year Follow-Up of the UNWIND Randomized Clinical Trial
Exercise and Escitalopram in the Treatment of Anxiety in Patients with Coronary Heart Disease: One Year Follow-Up of the UNWIND Randomized Clinical Trial Open
Anxiety is common among patients with coronary heart disease (CHD) and is associated with a worse prognosis. UNWIND was a 12-week randomized clinical trial comparing exercise and escitalopram to placebo on measures of anxiety, depression, …
View article: Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder: World Federation of Societies for Biological Psychiatry (WFSBP) and Australasian Society of Lifestyle Medicine (ASLM) taskforce
Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder: World Federation of Societies for Biological Psychiatry (WFSBP) and Australasian Society of Lifestyle Medicine (ASLM) taskforce Open
Lifestyle-based interventions are recommended as a foundational component of mental health care in clinical practice for adults with Major Depressive Disorder, where other evidence-based therapies can be added or used in combination. The f…
View article: Exercise and Escitalopram in the Treatment of Anxiety in Patients with Coronary Heart Disease: One Year Follow-Up of the UNWIND Randomized Clinical Trial
Exercise and Escitalopram in the Treatment of Anxiety in Patients with Coronary Heart Disease: One Year Follow-Up of the UNWIND Randomized Clinical Trial Open
Anxiety is common among patients with coronary heart disease (CHD) and is associated with a worse prognosis. UNWIND was a 12-week randomized clinical trial comparing exercise and escitalopram to placebo on measures of anxiety, depression, …
View article: Lifestyle modification and cognitive function among individuals with resistant hypertension: cognitive outcomes from the TRIUMPH trial
Lifestyle modification and cognitive function among individuals with resistant hypertension: cognitive outcomes from the TRIUMPH trial Open
Background: Resistant hypertension is associated with increased risk of cognitive decline, stroke, and dementia. Lifestyle modification has been suggested to improve cognitive function through its salutary effects on vascular function. Met…
View article: Longer term benefits of exercise and escitalopram in the treatment of anxiety in patients with coronary heart disease: Six month follow-up of the UNWIND randomized clinical trial
Longer term benefits of exercise and escitalopram in the treatment of anxiety in patients with coronary heart disease: Six month follow-up of the UNWIND randomized clinical trial Open
View article: Feasibility and benefits of exercise training in patients on maintenance dialysis
Feasibility and benefits of exercise training in patients on maintenance dialysis Open
Feasibility and benefits of exercise training in patients on maintenance dialysis. Fourteen of 174 patients receiving maintenance dialysis volunteered to participate in a 12-week exercise conditioning program. Seven patients attended more …
View article: Effects of Lifestyle Modification on Patients With Resistant Hypertension: Results of the TRIUMPH Randomized Clinical Trial
Effects of Lifestyle Modification on Patients With Resistant Hypertension: Results of the TRIUMPH Randomized Clinical Trial Open
Background: Although lifestyle modifications generally are effective in lowering blood pressure (BP) among patients with unmedicated hypertension and in those treated with 1 or 2 antihypertensive agents, the value of exercise and diet for …
View article: Trajectories of depressive symptoms and subsequent cognitive decline in older adults: a pooled analysis of two longitudinal cohorts
Trajectories of depressive symptoms and subsequent cognitive decline in older adults: a pooled analysis of two longitudinal cohorts Open
Background the course of depression is variable, but it is unknown how this variability over time affects long-term cognitive decline. Objective to examine the relationship of different trajectories of depressive symptoms on rates of subse…
View article: Impaired Endothelial Function in Coronary Heart Disease Patients With Depressive Symptomatology
Impaired Endothelial Function in Coronary Heart Disease Patients With Depressive Symptomatology Open
OBJECTIVES The purpose of this study was to assess whether depressive symptomatology was associated with vascular endothelial dysfunction in patients with coronary heart disease (CHD). BACKGROUND In patients with CHD, the presence of depre…
View article: Effect of Exercise, Escitalopram, or Placebo on Anxiety in Patients With Coronary Heart Disease
Effect of Exercise, Escitalopram, or Placebo on Anxiety in Patients With Coronary Heart Disease Open
ClinicalTrials.gov Identifier: NCT02516332.
View article: Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder
Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder Open
To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions …
View article: Lifestyle Interventions Reduce the Need for Guideline-Directed Antihypertensive Medication
Lifestyle Interventions Reduce the Need for Guideline-Directed Antihypertensive Medication Open
Background The 2017 ACC-AHA Hypertension Guideline recommends initiation of antihypertensive drug therapy based on blood pressure (BP) and an assessment of global cardiovascular disease (CVD) risk, but intensive lifestyle modification may …
View article: Effects of Acute Exercise on Anxiety Ratings in Patients With Coronary Heart Disease and Elevated Anxiety
Effects of Acute Exercise on Anxiety Ratings in Patients With Coronary Heart Disease and Elevated Anxiety Open
Purpose: To explore individual differences in state anxiety following a single, acute bout of aerobic exercise among anxious patients with diagnosed coronary heart disease (CHD). Methods: One hundred eighteen CHD patients with elevated sym…
View article: Risk stratification after acute myocardial infarction by amplitude–frequency mapping of cyclic variation of heart rate
Risk stratification after acute myocardial infarction by amplitude–frequency mapping of cyclic variation of heart rate Open
Background Blunted cyclic variation of heart rate (CVHR), measured as a decrease in CVHR amplitude (Acv), predicts mortality risk after acute myocardial infarction (AMI). However, Acv also can be reduced in mild sleep apnea with mild O 2 d…