James A. Hendrixson
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View article: Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength Open
Autophagy is a recycling pathway in which damaged proteins, protein aggregates, and organelles are delivered to lysosomes for degradation. Autophagy insufficiency is thought to contribute to osteoporosis. Accordingly, autophagy elimination…
View article: CRISPR activation of Tfeb, a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
CRISPR activation of Tfeb, a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength Open
Autophagy is a recycling pathway in which damaged or dysfunctional proteins, protein aggregates, and organelles are delivered to lysosomes for degradation. Insufficiency of autophagy is thought to contribute to several age-related diseases…
View article: Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice
Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice Open
Chaperone‐mediated autophagy (CMA) is a lysosome‐dependent degradation pathway that eliminates proteins that are damaged, partially unfolded, or targeted for selective proteome remodeling. CMA contributes to several cellular processes, inc…
View article: CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system
CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system Open
Cre-mediated recombination is frequently used for cell type-specific loss of function (LOF) studies. A major limitation of this system is recombination in unwanted cell types. CRISPR interference (CRISPRi) has been used effectively for glo…