James A. Madsen
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View article: Ion Mobility Gas-Phase Separation Enhances Top-Down Mass Spectrometry of Heavily Modified Guide RNA
Ion Mobility Gas-Phase Separation Enhances Top-Down Mass Spectrometry of Heavily Modified Guide RNA Open
As gene editing technologies enter the clinic, state-of-the-art characterization methods have been developed in parallel to assess the components of these paradigm-shifting medicines. One such component, the guide RNA (gRNA) element of CRI…
View article: Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry
Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry Open
The advancement of CRISPR-based gene editing tools into biotherapeutics offers the potential for cures to genetic disorders and for new treatment paradigms for even common diseases. Arguably, the most important component of a CRISPR-based …
View article: Data-independent oxonium ion profiling of multi-glycosylated biotherapeutics
Data-independent oxonium ion profiling of multi-glycosylated biotherapeutics Open
The characterization of glycosylation is required for many protein therapeutics. The emergence of antibody and antibody-like molecules with multiple glycan attachment sites has rendered glycan analysis increasingly more complicated. Relian…