Mark J. Adams
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View article: Genome-wide association study of adolescent-onset depression
Genome-wide association study of adolescent-onset depression Open
Adolescent depression is a heritable psychiatric condition with rising global prevalence and severe long-term outcomes, yet its biological underpinnings remain poorly understood. We conducted the first genome-wide association study of adol…
View article: A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison
A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison Open
Major depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation may be associated with the condition. However, previous DNA methylation studi…
View article: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies Open
Major Depression (MD) is a prevalent, disabling and life-limiting condition. The neurobiological associations of genetic risk for MD remain under-explored in large samples, with no comprehensive mega-analysis conducted to date. Our study a…
View article: A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits
A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits Open
Rare copy number variants (CNVs) are a key component of the genetic basis of psychiatric conditions, but have not been well characterized for most. We conducted a genome-wide CNV analysis across six diagnostic categories (N = 574,965): aut…
View article: Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects
Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects Open
Psychiatric conditions share common genes, but mechanisms that differentiate diagnoses remain unclear. We present a multidimensional framework for functional analysis of rare copy number variants (CNVs) across 6 diagnostic categories, incl…
View article: Genome-wide insights into generalised anxiety using a dimensional symptom severity approach
Genome-wide insights into generalised anxiety using a dimensional symptom severity approach Open
We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 696,563 individuals of European ancestry from 14 cohorts. We identified 82 independent genome-wide significant variants within 76 loci, 41 of w…
View article: Exploring the Therapeutic Effects of Psychedelics Administered to Military Veterans in Naturalistic Retreat Settings
Exploring the Therapeutic Effects of Psychedelics Administered to Military Veterans in Naturalistic Retreat Settings Open
Background : Military veterans are at risk of various mental health conditions, with profound implications for post‐deployment quality of life. Current treatment options encounter high dropout rates and non‐responsiveness, and overlook the…
View article: Fine-mapping genomic loci refines bipolar disorder risk genes
Fine-mapping genomic loci refines bipolar disorder risk genes Open
Bipolar disorder is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 bipolar disorder risk loci, the causal SNPs and genes within these loci remain unknown. We applie…
View article: Impact of lifestyle in chronic pain and depression: a propensity score analysis in UK biobank
Impact of lifestyle in chronic pain and depression: a propensity score analysis in UK biobank Open
Background Chronic pain and depression are prevalent global health burdens that frequently co-occur, leading to worse outcomes than either condition alone. Current treatments are frequently inadequate, particularly for comorbid chronic pa…
View article: The UK Biobank mental health enhancement 2022: Methods and results
The UK Biobank mental health enhancement 2022: Methods and results Open
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40–…
View article: The UK Biobank mental health enhancement 2022: Methods and results
The UK Biobank mental health enhancement 2022: Methods and results Open
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40–…
View article: Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts
Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts Open
Background Peripheral inflammatory markers, including serum interleukin 6 (IL-6), are associated with depression, but less is known about how these markers associate with depression at different stages of the life course. Methods We examin…
View article: The UK Biobank Mental Health Enhancement 2022: Methods and Results
The UK Biobank Mental Health Enhancement 2022: Methods and Results Open
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40-…
View article: Direct and indirect genetic pathways between parental neuroticism and offspring emotional problems across development: evidence from 7 cohorts across 5 European nations
Direct and indirect genetic pathways between parental neuroticism and offspring emotional problems across development: evidence from 7 cohorts across 5 European nations Open
Disentangling direct and indirect genetic pathways underlying the intergenerational transmission of emotional problems could guide preventative strategies and further the understanding of the role of parental mental health in children’s ou…
View article: From peas to people - using quantitative traits to aid genetic discovery in depression
From peas to people - using quantitative traits to aid genetic discovery in depression Open
A key component of Mendels work is what we now refer to as pleiotropy - when variation in one gene gives rise to variation in multiple phenotypes. This study focuses on aiding genetic discovery in depression by revisiting the depressed phe…
View article: Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts
Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts Open
Background Diagnostic criteria for major depressive disorder allow for heterogeneous symptom profiles but genetic analysis of major depressive symptoms has the potential to identify clinical and etiological subtypes. There are several chal…
View article: Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling Open
The major anxiety disorders (ANX; including generalized anxiety disorder, panic disorder, and phobias ) are highly prevalent, often onset early, persist throughout life, and cause substantial global disability. Although distinct in their c…
View article: Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study
Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study Open
Importance Understanding antidepressant mechanisms could help design more effective and tolerated treatments. Objective Identify DNA methylation (DNAm) changes associated with antidepressant exposure. Design Case-control methylome-wide ass…
View article: Data Resource Profile: Whole Blood DNA Methylation Resource in Generation Scotland (MeGS)
Data Resource Profile: Whole Blood DNA Methylation Resource in Generation Scotland (MeGS) Open
We have generated whole-blood DNA methylation profiles from 18,869 Generation Scotland Scottish Family Health Study (GS) participants, resulting in, at the time of writing, the largest single-cohort DNA methylation resource for basic biolo…
View article: Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts
Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts Open
Peripheral inflammatory markers, including serum IL-6, are associated with depression, but less is known about how these markers associate with depression at different stages of the life-course. We examined associations between serum IL-6 …
View article: A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases <i>v.</i> controls in two large population samples
A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases <i>v.</i> controls in two large population samples Open
Background The brain can be represented as a network, with nodes as brain regions and edges as region-to-region connections. Nodes with the most connections (hubs) are central to efficient brain function. Current findings on structural dif…
View article: Fine-mapping genomic loci refines bipolar disorder risk genes
Fine-mapping genomic loci refines bipolar disorder risk genes Open
Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 BD risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite…
View article: Distinguishing different psychiatric disorders using DDx-PRS
Distinguishing different psychiatric disorders using DDx-PRS Open
Despite great progress on methods for case-control polygenic prediction (e.g. schizophrenia vs. control), there remains an unmet need for a method that genetically distinguishes clinically related disorders (e.g. schizophrenia (SCZ) vs. bi…
View article: Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference Open
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to …
View article: Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants
Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants Open
Introduction Genome-Wide Association Studies (GWAS) over-represent European ancestries compared to the global population, neglecting all other ancestry groups and low-income nations. Consequently, polygenic risk scores (PRS) more accuratel…