James Agathos
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View article: Subcortical modulation of the salience network during negative emotional processing in mood and anxiety disorders
Subcortical modulation of the salience network during negative emotional processing in mood and anxiety disorders Open
Dysfunctional processing of negative emotional events is a key transdiagnostic feature of mood and anxiety disorders. This dysfunction is often associated with aberrant functioning of fronto-insular/cingulate regions involved in salience p…
View article: Altered basal forebrain regulation of intrinsic brain networks in depressive and anxiety disorders
Altered basal forebrain regulation of intrinsic brain networks in depressive and anxiety disorders Open
Depressive and anxiety disorders are characterized by altered connectivity within and between the default mode (DMN) and salience networks. Basal forebrain subdivisions, critical for regulating network activity, remain understudied across …
View article: Neuroimaging evidence of disturbed self-appraisal in posttraumatic stress disorder: A systematic review
Neuroimaging evidence of disturbed self-appraisal in posttraumatic stress disorder: A systematic review Open
This paper proposes a mechanistic account of how neural dysfunctions may manifest clinically in PTSD and inform targeted selection of appropriate treatment options. We present a research agenda for future work to advance the field.
View article: Improving mental health following multiple disasters in Australia: a randomized controlled trial of the Skills for Life Adjustment and Resilience (SOLAR) programme
Improving mental health following multiple disasters in Australia: a randomized controlled trial of the Skills for Life Adjustment and Resilience (SOLAR) programme Open
Background: The mental health impacts of climate change-related disasters are significant. However, access to mental health services is often limited by the availability of trained clinicians. Although building local community capability f…
View article: Subcortical contributions to salience network functioning during negative emotional processing
Subcortical contributions to salience network functioning during negative emotional processing Open
Core regions of the salience network (SN), including the anterior insula (aINS) and dorsal anterior cingulate cortex (dACC), coordinate rapid adaptive changes in attentional and autonomic processes in response to negative emotional events.…
View article: Differential engagement of the posterior cingulate cortex during cognitive restructuring of negative self- and social beliefs
Differential engagement of the posterior cingulate cortex during cognitive restructuring of negative self- and social beliefs Open
Negative self-beliefs are a core feature of psychopathology, encompassing both negative appraisals about oneself directly (i.e. self-judgment) and negative inferences of how the self is appraised by others (i.e. social judgment). Challengi…
View article: Mental health across the early years in the military
Mental health across the early years in the military Open
Background The mental health impact of the initial years of military service is an under-researched area. This study is the first to explore mental health trajectories and associated predictors in military members across the first 3–4 year…
View article: Prevalence and treatment implications of ICD-11 complex PTSD in Australian treatment-seeking current and ex-serving military members
Prevalence and treatment implications of ICD-11 complex PTSD in Australian treatment-seeking current and ex-serving military members Open
Background: Despite growing support for the distinction between posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) as separate diagnoses within the ICD-11 psychiatric taxonomy, the prevalence and treatment implications of CPTSD …
View article: Adjustment Disorder: Current Developments and Future Directions
Adjustment Disorder: Current Developments and Future Directions Open
Despite its high prevalence in clinical and consultant liaison psychiatry populations, adjustment disorder research has traditionally been hindered by its lack of clear diagnostic criteria. However, with the greater diagnostic clarity prov…