J. Douglas Armstrong
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View article: SynaptopathyDB integrates synaptic proteomes, genetic and phenotypic data to advance research on nervous system disorders
SynaptopathyDB integrates synaptic proteomes, genetic and phenotypic data to advance research on nervous system disorders Open
Synaptic dysfunction resulting from pathogenic variants in genes encoding synaptic proteins is a major contributor to brain and behavioural disorders, collectively termed synaptopathies. To facilitate research into the genetic basis and cl…
View article: Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds
Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds Open
Introduction The presence of central nervous system (CNS) safety concerns during early clinical testing that were not picked up in standard preclinical assessment is a major cause of attrition in drug development. It is also very expensive…
View article: ASASSN-24fw: An 8-month long, 4.1 mag, optically achromatic and polarized dimming event
ASASSN-24fw: An 8-month long, 4.1 mag, optically achromatic and polarized dimming event Open
We discuss ASASSN-24fw, a 13th-magnitude star that optically faded by mag starting in September 2024 after over a decade of quiescence in ASAS-SN. The dimmimg lasted $$8 months before returning to quiescence in late May 2025. The spectral…
View article: ASASSN-24fw: An 8-month long, 4.1 mag, optically achromatic and polarized dimming event
ASASSN-24fw: An 8-month long, 4.1 mag, optically achromatic and polarized dimming event Open
We discuss ASASSN-24fw, a 13th-magnitude star that optically faded by mag starting in September 2024 after over a decade of quiescence in ASAS-SN. The dimmimg lasted $$8 months before returning to quiescence in late May 2025. The s…
View article: Protein trafficking and synaptic demand configure complex and dynamic synaptome architectures of individual neurons
Protein trafficking and synaptic demand configure complex and dynamic synaptome architectures of individual neurons Open
Excitatory synapses are the most abundant synapse type in the brain and are essential for behaviour and implicated in hundreds of brain disorders. These synapses exhibit striking structural and functional diversity, arising from difference…
View article: SynaptopathyDB: a resource for studying the genetic and synaptic basis of nervous system disorders
SynaptopathyDB: a resource for studying the genetic and synaptic basis of nervous system disorders Open
Synaptic dysfunction resulting from pathogenic variants in genes encoding synaptic proteins is a major contributor to brain and behavioural disorders, collectively termed synaptopathies. To facilitate research into the genetic basis and cl…
View article: Computational Pipeline for Analysis of Biomedical Networks with BioNAR
Computational Pipeline for Analysis of Biomedical Networks with BioNAR Open
In a living cell, proteins interact to assemble both transient and constant molecular complexes, which transfer signals/information around internal pathways. Modern proteomic techniques can identify the constituent components of these comp…
View article: Improved prediction of hiking speeds using a data driven approach
Improved prediction of hiking speeds using a data driven approach Open
Hikers and hillwalkers typically use the gradient in the direction of travel (walking slope) as the main variable in established methods for predicting walking time (via the walking speed) along a route. Research into fell-running has sugg…
View article: Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease
Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease Open
Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. Video-tracking, in particular, lends itself to automated machine-learning technologies…
View article: BioNAR: An Integrated Biological Network Analysis Package in Bioconductor
BioNAR: An Integrated Biological Network Analysis Package in Bioconductor Open
Biological function in protein complexes emerges from more than just the sum of their parts: Molecules interact in a range of different subcomplexes and transfer signals/information around internal pathways. Modern proteomic techniques are…
View article: Virtual Fly Brain—An interactive atlas of the Drosophila nervous system
Virtual Fly Brain—An interactive atlas of the Drosophila nervous system Open
As a model organism, Drosophila is uniquely placed to contribute to our understanding of how brains control complex behavior. Not only does it have complex adaptive behaviors, but also a uniquely powerful genetic toolkit, increasingly comp…
View article: Soluble metallogels including antimicrobial silver metallogels
Soluble metallogels including antimicrobial silver metallogels Open
A product includes a metallogel material having metal ions dispersed in an assembly having an organic compound. A method includes combining a metal salt, an organic compound precursor, and a glyme for forming a metallogel material having m…
View article: Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases
Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases Open
The seamless integration of human disease-related mutation data into protein structures is an essential component of any attempt to correctly assess the impact of the mutation. The key step preliminary to any structural modelling is the id…
View article: BioNAR: an integrated biological network analysis package in bioconductor
BioNAR: an integrated biological network analysis package in bioconductor Open
Motivation Biological function in protein complexes emerges from more than just the sum of their parts: molecules interact in a range of different sub-complexes and transfer signals/information around internal pathways. Modern proteomic te…
View article: Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases
Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases Open
The seamless integration of human disease-related mutation data into protein structures is an essential component of any attempt to correctly assess the impact of the mutation. The key step preliminary to any structural modelling is the id…
View article: Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain
Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain Open
The aim of this study was to develop and refine a heterologous mouse model of endometriosis-associated pain in which non-evoked responses, more relevant to the patient experience, were evaluated. Immunodeficient female mice (N = 24) were e…
View article: Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain
Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain Open
The aim of this study was to develop and refine a heterologous mouse model of endometriosis-associated pain in which non-evoked responses, more relevant to the patient experience, were evaluated. Immunodeficient female mice (N = 24) were e…
View article: Synaptome.db: a bioconductor package for synaptic proteomics data
Synaptome.db: a bioconductor package for synaptic proteomics data Open
Summary The neuronal synapse is underpinned by a large and diverse proteome but the molecular evidence is spread across many primary datasets. These data were recently curated into a single dataset describing a landscape of ∼8000 proteins …
View article: Mena regulates the LINC complex to control actin–nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression
Mena regulates the LINC complex to control actin–nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression Open
Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes (IACs), play key roles in cancer progression and metastasis. We investigated systems-level changes in the integrin adhesome during metastatic …
View article: Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain
Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain Open
Endometriosis (ENDO) and interstitial cystitis/bladder pain syndrome (IC/BPS) are chronic pain conditions for which better treatments are urgently needed. Development of new therapies with proven clinical benefit has been slow. We have con…
View article: A configurable model of the synaptic proteome reveals the molecular mechanisms of disease co-morbidity
A configurable model of the synaptic proteome reveals the molecular mechanisms of disease co-morbidity Open
Synapses contain highly complex proteomes which control synaptic transmission, cognition and behaviour. Genes encoding synaptic proteins are associated with neuronal disorders many of which show clinical co-morbidity. Our hypothesis is tha…
View article: A Systematic Nomenclature for the Drosophila Ventral Nerve Cord
A Systematic Nomenclature for the Drosophila Ventral Nerve Cord Open
Drosophila melanogaster is an established model for neuroscience research with relevance in biology and medicine. Until recently, research on the Drosophila brain was hindered by the lack of a complete and uniform nomenclature. Recognizing…
View article: Temporal dissociation of phencyclidine: Induced locomotor and social alterations in rats using an automated homecage monitoring system – implications for the 3Rs and preclinical drug discovery
Temporal dissociation of phencyclidine: Induced locomotor and social alterations in rats using an automated homecage monitoring system – implications for the 3Rs and preclinical drug discovery Open
Background: Rodent behavioural assays are widely used to delineate the mechanisms of psychiatric disorders and predict the efficacy of drug candidates. Conventional behavioural paradigms are restricted to short time windows and involve tra…
View article: Dissecting the Shared and Context-Dependent Pathways Mediated by the p140Cap Adaptor Protein in Cancer and in Neurons
Dissecting the Shared and Context-Dependent Pathways Mediated by the p140Cap Adaptor Protein in Cancer and in Neurons Open
The p140Cap adaptor protein is a scaffold molecule physiologically expressed in few epithelial tissues, such as the mammary gland, and in differentiated neurons. While the role of p140Cap in mammary gland epithelia is not still understood,…