James Auta
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View article: Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy
Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy Open
View article: Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation
Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation Open
View article: Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up‐regulation of<i>Fmr1</i>gene expression in rat cerebellum
Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up‐regulation of<i>Fmr1</i>gene expression in rat cerebellum Open
Background Alcohol intoxication produces ataxia by affecting the cerebellum, which coordinates movements. Fragile X mental retardation (FMR) protein is a complex regulator of RNA and synaptic plasticity implicated in fragile X‐associated t…
View article: Gene expression of methylation cycle and related genes in lymphocytes and brain of patients with schizophrenia and non-psychotic controls
Gene expression of methylation cycle and related genes in lymphocytes and brain of patients with schizophrenia and non-psychotic controls Open
Some of the biochemical abnormalities underlying schizophrenia, involve differences in methylation and methylating enzymes, as well as other related target genes. We present results of a study of differences in mRNA expression in periphera…
View article: Concordance of Immune-Related Markers in Lymphocytes and Prefrontal Cortex in Schizophrenia
Concordance of Immune-Related Markers in Lymphocytes and Prefrontal Cortex in Schizophrenia Open
Schizophrenia is a severe neuropsychiatric disorder associated with a wide array of transcriptomic and neurobiochemical changes. Genome-wide transcriptomic profiling conducted in postmortem brain have provided novel insights into the patho…
View article: Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics
Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics Open
View article: Essential role for neuronal nitric oxide synthase in acute ethanol-induced motor impairment
Essential role for neuronal nitric oxide synthase in acute ethanol-induced motor impairment Open
View article: Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1)
Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1) Open
View article: Acute Ethanol Produces Ataxia and Induces <i>Fmr1</i> Expression via Histone Modifications in the Rat Cerebellum
Acute Ethanol Produces Ataxia and Induces <i>Fmr1</i> Expression via Histone Modifications in the Rat Cerebellum Open
Background The cerebellum is fundamental for motor coordination and therefore crucial in ethanol (EtOH)‐induced ataxia. EtOH contributes to cerebellar pathophysiology. Fragile‐X mental retardation protein ( FMRP ) is a complex regulator of…
View article: Potential role for histone deacetylation in chronic diazepam‐induced downregulation of α1‐<scp>GABA<sub>A</sub></scp>receptor subunit expression
Potential role for histone deacetylation in chronic diazepam‐induced downregulation of α1‐<span>GABA<sub>A</sub></span>receptor subunit expression Open
Corroborating evidence indicate that the downregulation of GABA A receptor subunit expression may underlie tolerance to the anticonvulsant and anxiolytic actions of benzodiazepine ( BZ ) ligands that act as full allosteric modulators ( FAM…
View article: Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on δ-Containing GABAA Receptor Expression in the Cerebellum of Subjects with Alcohol Use Disorders (AUD)
Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on δ-Containing GABAA Receptor Expression in the Cerebellum of Subjects with Alcohol Use Disorders (AUD) Open
Together, these results support the hypothesis that aberrant DNA methylation pathways may be involved in cerebellar pathophysiology of alcoholism. Furthermore, this work provides novel evidence for a central role of DNA methylation mechani…
View article: Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain
Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain Open
These results indicate a decreased "methylation index" in liver and an increased "methylation index" in cerebellum. The opposing changes of the "methylation index" suggest altered DNA methylation in liver and cerebellum, thus implicating o…
View article: M4. Epigeneticly Related mRNA Levels in Lymphocytes of Schizophrenic and Nonpsychotic Controls
M4. Epigeneticly Related mRNA Levels in Lymphocytes of Schizophrenic and Nonpsychotic Controls Open
Background: Epigenetic dysregulation may be involved in the underlying molecular deficits in schizophrenia (SZ). Previous research by our group has show hypermethylation of GABAergic promoter gene in and increases in DNMT1 and DNMT3A in po…