James B. Fallon
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View article: Selective Optogenetic Inhibition of Slow Conducting Fibers at the Level of the Sciatic Nerve Trunk in the Mouse
Selective Optogenetic Inhibition of Slow Conducting Fibers at the Level of the Sciatic Nerve Trunk in the Mouse Open
This study extends the current understanding of using light-mediated inhibition of nociceptive activity in a mixed peripheral nerve to the level of the axon and measures the underlying changes in neural activity in the sciatic nerve. This …
View article: Towards a closed loop retinal prosthesis: measuring electrically evoked retinal responses using large electrodes
Towards a closed loop retinal prosthesis: measuring electrically evoked retinal responses using large electrodes Open
Objective. Sensory prostheses use arrays of electrodes to stimulate neural tissue and restore a sense of vision or hearing. At perceptible levels of stimulation, the current from each electrode spreads and causes overlapping regions of neu…
View article: Abdominal Vagus Nerve Stimulation Increases Firing in the Rat Locus Coeruleus
Abdominal Vagus Nerve Stimulation Increases Firing in the Rat Locus Coeruleus Open
Abdominal VNS activated the LC without causing changes to vitals and could be used as an alternative approach to providing VNS therapy for brain disorders such as drug-resistant epilepsy and depression.
View article: Objective assessment of tinnitus laterality
Objective assessment of tinnitus laterality Open
Tinnitus is a condition which involves hearing sounds not present externally. This common condition can lead to a range of symptoms, including depression, resulting in a severe impact on quality of life. There are currently no reliable tre…
View article: Spatially precise activation of the mouse cochlea with a multi-channel hybrid cochlear implant
Spatially precise activation of the mouse cochlea with a multi-channel hybrid cochlear implant Open
Objective. Cochlear implants are among the few clinical interventions for people with severe or profound hearing loss. However, current spread during monopolar electrical stimulation results in poor spectral resolution, prompting the explo…
View article: Ensemble responses of auditory midbrain neurons in the cat to speech stimuli at different signal-to-noise ratios
Ensemble responses of auditory midbrain neurons in the cat to speech stimuli at different signal-to-noise ratios Open
Originally reserved for those who are profoundly deaf, cochlear implantation is now common for people with partial hearing loss, particularly when combined with a hearing aid. This combined intervention enhances speech comprehension and so…
View article: Combined-electrical optogenetic stimulation but not channelrhodopsin kinetics improves the fidelity of high rate stimulation in the auditory pathway in mice
Combined-electrical optogenetic stimulation but not channelrhodopsin kinetics improves the fidelity of high rate stimulation in the auditory pathway in mice Open
Novel stimulation methods are needed to overcome the limitations of contemporary cochlear implants. Optogenetics is a technique that confers light sensitivity to neurons via the genetic introduction of light-sensitive ion channels. By cont…
View article: Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” (Adv. Sci. 30/2024)
Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” (Adv. Sci. 30/2024) Open
Vector‐Free Gene Augmentation Therapy In article number 2401392, Jeremy L. Pinyon, Gary D. Housley, and coworkers describe ‘conductivityclamped’ gene electrotransfer (CC‐GET) which broadly enables vector‐free nucleic acid therapeutics. In …
View article: Freestanding rGO neural electrodes with tunable porous structures
Freestanding rGO neural electrodes with tunable porous structures Open
Penetrating recording neural electrodes prepared from materials with miniaturized geometrical size could improve the longevity of implants by reducing the chronic inflammatory response. Reduced graphene oxide (rGO) microfibers with tunable…
View article: Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down”
Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” Open
Viral vectors and lipofection‐based gene therapies have dispersion‐dependent transduction/transfection profiles that thwart precise targeting. The study describes the development of focused close‐field gene electrotransfer (GET) technology…
View article: Impact of opsin kinetics on high-rate stimulation of the auditory nerve in mice
Impact of opsin kinetics on high-rate stimulation of the auditory nerve in mice Open
Optogenetic stimulation improves spectral resolution compared to electrical stimulation in preclinical cochlear implant studies but remains unreliable at the high stimulation rates needed for precise temporal resolution. Combined optogenet…
View article: Flexible neural recording electrodes based on reduced graphene oxide interfaces
Flexible neural recording electrodes based on reduced graphene oxide interfaces Open
Conventional recording neural electrodes are made of stiff materials such as metal or silicon which triggers unwanted inflammation and does not provide intimate contact with brain tissue. Flexible neural electrodes have therefore been incr…
View article: Spread of activation and interaction between channels with multi-channel optogenetic stimulation in the mouse cochlea
Spread of activation and interaction between channels with multi-channel optogenetic stimulation in the mouse cochlea Open
For individuals with severe to profound hearing loss resulting from irreversibly damaged hair cells, cochlear implants can be used to restore hearing by delivering electrical stimulation directly to the spiral ganglion neurons. However, cu…
View article: Selective recording of physiologically evoked neural activity in a mixed autonomic nerve using a minimally invasive array
Selective recording of physiologically evoked neural activity in a mixed autonomic nerve using a minimally invasive array Open
Real-time closed-loop control of neuromodulation devices requires long-term monitoring of neural activity in the peripheral nervous system. Although many signal extraction methods exist, few are both clinically viable and designed for extr…
View article: Stimulation parameters for directional vagus nerve stimulation
Stimulation parameters for directional vagus nerve stimulation Open
Background Autonomic nerve stimulation is used as a treatment for a growing number of diseases. We have previously demonstrated that application of efferent vagus nerve stimulation (eVNS) has promising glucose lowering effects in a rat mod…
View article: Combined optogenetic and electrical stimulation of the sciatic nerve for selective control of sensory fibers
Combined optogenetic and electrical stimulation of the sciatic nerve for selective control of sensory fibers Open
Introduction Electrical stimulation offers a drug-free alternative for the treatment of many neurological conditions, such as chronic pain. However, it is not easy to selectively activate afferent or efferent fibers of mixed nerves, nor th…
View article: Auditory nerve responses to combined optogenetic and electrical stimulation in chronically deaf mice
Auditory nerve responses to combined optogenetic and electrical stimulation in chronically deaf mice Open
Objective . Optogenetic stimulation of the auditory nerve offers the ability to overcome the limitations of cochlear implants through spatially precise stimulation, but cannot achieve the temporal precision nor temporal fidelity required f…
View article: Abdominal vagus nerve stimulation alleviates collagen-induced arthritis in rats
Abdominal vagus nerve stimulation alleviates collagen-induced arthritis in rats Open
Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disease. Despite therapeutic advances, a significant proportion of RA patients are resistant to pharmacological treatment. Stimulation of the cervical vagus nerve is a promisi…
View article: Blood glucose modulation and safety of efferent vagus nerve stimulation in a type 2 diabetic rat model
Blood glucose modulation and safety of efferent vagus nerve stimulation in a type 2 diabetic rat model Open
Vagus nerve stimulation is emerging as a promising treatment for type 2 diabetes. Here, we evaluated the ability of stimulation of the vagus nerve to reduce glycemia in awake, freely moving metabolically compromised rats. A model of type 2…
View article: Improving Deep Brain Stimulation Electrode Performance in vivo Through Use of Conductive Hydrogel Coatings
Improving Deep Brain Stimulation Electrode Performance in vivo Through Use of Conductive Hydrogel Coatings Open
Active implantable neurological devices like deep brain stimulators have been used over the past few decades to treat movement disorders such as those in people with Parkinson’s disease and more recently, in psychiatric conditions like obs…
View article: Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces
Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces Open
Objective. Neuromodulation of visceral nerves is being intensively studied for treating a wide range of conditions, but effective translation requires increasing the efficacy and predictability of neural interface performance. Here we use …
View article: Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities
Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities Open
Objective . Established guidelines for safe levels of electrical stimulation for neural prostheses are based on a limited range of the stimulus parameters used clinically. Recent studies have reported particulate platinum (Pt) associated w…
View article: Oculomotor Responses to Dynamic Stimuli in a 44-Channel Suprachoroidal Retinal Prosthesis
Oculomotor Responses to Dynamic Stimuli in a 44-Channel Suprachoroidal Retinal Prosthesis Open
Retinal implant users can make naturalistic eye movements in response to moving stimuli, highlighting the potential for eye tracker feedback to improve perceptual localization and image stabilization in camera-based visual prostheses.
View article: Recording of Electrically Evoked Neural Activity and Bladder Pressure Responses in Awake Rats Chronically Implanted With a Pelvic Nerve Array
Recording of Electrically Evoked Neural Activity and Bladder Pressure Responses in Awake Rats Chronically Implanted With a Pelvic Nerve Array Open
Bioelectronic medical devices are well established and widely used in the treatment of urological dysfunction. Approved targets include the sacral S3 spinal root and posterior tibial nerve, but an alternate target is the group of pelvic sp…
View article: Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning
Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning Open
Chronic tinnitus is a debilitating condition which affects 10–20% of adults and can severely impact their quality of life. Currently there is no objective measure of tinnitus that can be used clinically. Clinical assessment of the conditio…
View article: Chronic intracochlear electrical stimulation at high charge densities: reducing platinum dissolution
Chronic intracochlear electrical stimulation at high charge densities: reducing platinum dissolution Open
Objective. Cochleae of long-term cochlear implant users have shown evidence of particulate platinum (Pt) corroded from the surface of Pt electrodes. The pathophysiological effect of Pt within the cochlea has not been extensively investigat…
View article: Implantation of a pelvic nerve array in rats v1
Implantation of a pelvic nerve array in rats v1 Open
A pelvic nerve array is custom designed for implantation onto the pelvic nerve of male rats. This device is used for long-term (recovery) experiments. The device can electrically stimulate the pelvic nerve as well as record electrically ev…
View article: Hybrid optogenetic and electrical stimulation for greater spatial resolution and temporal fidelity of cochlear activation
Hybrid optogenetic and electrical stimulation for greater spatial resolution and temporal fidelity of cochlear activation Open
Compared to electrical stimulation, optogenetic stimulation has the potential to improve the spatial precision of neural activation in neuroprostheses, but it requires intense light and has relatively poor temporal kinetics. We tested the …