James E. Barrett
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View article: Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer
Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer Open
Background Aging is a key risk factor for many diseases, including cancer, and a better understanding of its underlying molecular mechanisms may help to prevent, delay, or treat age-related pathologies. Epigenetic alterations such as DNA m…
View article: Epigenetic signatures in surrogate tissues are able to assess cancer risk and indicate the efficacy of preventive measures
Epigenetic signatures in surrogate tissues are able to assess cancer risk and indicate the efficacy of preventive measures Open
Background In order to advance personalized primary cancer prevention, surrogate endpoint biomarkers in distant, easy to access tissues (i.e., field defect indicators) reflecting field cancerization in the organ at risk are essential. Meth…
View article: Performance of the <scp>WID</scp>‐<scp>qEC</scp> test to detect uterine cancers in black women with abnormal uterine bleeding: A prospective observational cohort study in Ghana
Performance of the <span>WID</span>‐<span>qEC</span> test to detect uterine cancers in black women with abnormal uterine bleeding: A prospective observational cohort study in Ghana Open
The burden of uterine cancer is growing and, in the US and UK, mortality rates are poorest among black women. Early detection of these cancers is critical and poor performance of ultrasound in black women may contribute to adverse outcomes…
View article: Cervical cancer screening using DNA methylation triage in a real-world population
Cervical cancer screening using DNA methylation triage in a real-world population Open
Cervical cancer (CC) screening in women comprises human papillomavirus (HPV) testing followed by cytology triage of positive cases. Drawbacks, including cytology’s low reproducibility and requirement for short screening intervals, raise th…
View article: High performance of the <scp>DNA</scp> methylation‐based <scp>WID‐qEC</scp> test for detecting uterine cancers independent of sampling modalities
High performance of the <span>DNA</span> methylation‐based <span>WID‐qEC</span> test for detecting uterine cancers independent of sampling modalities Open
Endometrial cancer (EC) is the most prevalent gynaecological cancer in high‐income countries and its incidence is continuing to rise sharply. Simple and objective tools to reliably detect women with EC are urgently needed. We recently deve…
View article: Are early pregnancies implanted close to the tubal ostia at increased risk of miscarriage? A prospective observational study
Are early pregnancies implanted close to the tubal ostia at increased risk of miscarriage? A prospective observational study Open
Introduction: The aim of this article is to assess any association between the risk of miscarriage and the distance of an early pregnancy from the closest tubal ostia. Methods: Early pregnancy was defined as a gestational sac ⩽ 15 mm mean …
View article: <scp>HPV</scp>‐induced host epigenetic reprogramming is lost upon progression to high‐grade cervical intraepithelial neoplasia
<span>HPV</span>‐induced host epigenetic reprogramming is lost upon progression to high‐grade cervical intraepithelial neoplasia Open
The impact of a pathogen on host disease can only be studied in samples covering the entire spectrum of pathogenesis. Persistent oncogenic human papilloma virus (HPV) infection is the most common cause for cervical cancer. Here, we investi…
View article: The <scp>WID‐EC</scp> test for the detection and risk prediction of endometrial cancer
The <span>WID‐EC</span> test for the detection and risk prediction of endometrial cancer Open
The incidence of endometrial cancer is rising. Measures to identify women at risk and to detect endometrial cancer earlier are required to reduce the morbidity triggered by the aggressive treatment required for advanced endometrial cancer.…
View article: DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test
DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test Open
Background Cervical screening using primary human papilloma virus (HPV) testing and cytology is being implemented in several countries. Cytology as triage for colposcopy referral suffers from several shortcomings. HPV testing overcomes som…
View article: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women Open
Background Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising …
View article: Premature germ cells in the ejaculate of a 4-year-old male Labrador Retriever
Premature germ cells in the ejaculate of a 4-year-old male Labrador Retriever Open
A healthy, 4-year-old, Labrador Retriever was presented for routine semen collection for cryopreservation. Ejaculate had an abundanceof atypical round cells along with substantial morphologically abnormal sperm. Atypical round cells were i…
View article: The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples
The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples Open
Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the DNA methylome in 2,818 cervica…
View article: The DNA methylome of cervical cells can predict the presence of ovarian cancer
The DNA methylome of cervical cells can predict the presence of ovarian cancer Open
The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived cervical cells from…
View article: Additional file 3 of Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock
Additional file 3 of Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock Open
Additional file 3: Table S8. WID epithelial clock intercept and coefficients.
View article: Additional file 2 of The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer
Additional file 2 of The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer Open
Additional file 2. The top 5,000 differentially methylated CpGs.
View article: Additional file 2 of Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock
Additional file 2 of Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock Open
Additional file 2: Table S7. WID general clock intercept and coefficients.
View article: Additional file 4 of Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock
Additional file 4 of Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock Open
Additional file 4: Table S9. WID immune clock intercept and coefficients.
View article: Additional file 2 of DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test
Additional file 2 of DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test Open
Additional file 2: Original data for calculations in the manuscript.
View article: Performance comparison and in-silico harmonization of commercial platforms for DNA methylome analysis by targeted bisulfite sequencing
Performance comparison and in-silico harmonization of commercial platforms for DNA methylome analysis by targeted bisulfite sequencing Open
DNA methylation is a key epigenetic modification in the regulation of cell fate and differentiation, and its analysis is gaining increasing importance in both basic and clinical research. Targeted Bisulfite Sequencing (TBS) has become the …